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Medicine composition of naloxone hydrochloride and medicine purpose thereof

A technology of naloxone hydrochloride and its composition, which is applied in the field of biomedicine, can solve problems such as no related reports about naloxone hydrochloride and cervical cancer, and achieve the effects of highlighting substantive features, improving therapeutic effects, and significant progress

Inactive Publication Date: 2016-12-07
林翔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between naloxone hydrochloride and its pharmaceutical composition and cervical cancer

Method used

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  • Medicine composition of naloxone hydrochloride and medicine purpose thereof
  • Medicine composition of naloxone hydrochloride and medicine purpose thereof
  • Medicine composition of naloxone hydrochloride and medicine purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0020] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0021] Separation method: (a) Pulverize milk thistle (2kg), extract with 75% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate until no alcohol smell (4L), and successively use petroleum ether (4L×3 times), ethyl acetate (4L × 3 times) and water-saturated n-butanol (4L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step ( a) Use D101 macroporous resin to remove impurities from the n-butanol extract, first elute with 15% ethanol for 6 column volumes, then use 70% ethanol for 10 column volumes, collect 70% eluate, and con...

Embodiment 2

[0025] Embodiment 2: pharmacological action

[0026]In this example, the human cervical cancer Hela cell suspension was used to prepare a rat model of cervical cancer, and the expression levels of Survivin, Caspase-3 and Caspase-7 in the cervical cancer tissues of the three groups of rats were detected. Observe the anti-cervical cancer effect of the drug on down-regulating the level of apoptosis inhibitor Survivin and improving the expression of apoptosis factors Caspase-3 and Caspase-7 in rats with cervical cancer.

[0027] 1. Materials and methods

[0028] 1.1 Animals

[0029] 6-week-old female Wistar rats with an average body weight of (153±14) g were purchased from the Shanghai Animal Center of the Chinese Academy of Sciences.

[0030] 1.2 Reagents and samples

[0031] Naloxone hydrochloride was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. ...

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PUM

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Abstract

The invention discloses a medicine composition of naloxone hydrochloride and a medicine purpose thereof. The medicine composition of naloxone hydrochloride comprises naloxone hydrochloride and a natural product compound (I) with a novel structure; when the naloxone hydrochloride and the compound (I) singly act, the function of treating cervical cancer is realized; when the naloxone hydrochloride and the compound (I) jointly act, the treatment effect is further improved, and a medicine for treating cervical cancer can be developed. Compared with prior art, the medicine composition has outstanding material characteristic and obvious process.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of naloxone hydrochloride, in particular to a pharmaceutical composition of naloxone hydrochloride and its application in cervical cancer. Background technique [0002] Naloxone hydrochloride is a pure opioid receptor antagonist with no intrinsic activity itself. However, it can competitively antagonize various opioid receptors and has a strong affinity for μ receptors. Naloxone takes effect quickly and has a strong antagonistic effect. Naloxone also reverses all effects of opioid agonists, including analgesia. In addition, it also has resuscitating effects that are not related to antagonizing opioid receptors. It can quickly reverse the respiratory depression caused by opioid analgesics, can cause high excitement, and make cardiovascular hyperfunction. This product still has anti-shock effect. Morphine-like dependence, withdrawal symptoms and respiratory depression...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/10A61K31/485A61K31/337A61P35/00A61P15/00
CPCA61K31/337A61K31/485A61K36/28C07D493/10A61K2300/00
Inventor 林翔
Owner 林翔
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