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41 results about "Hyperfunction" patented technology

In mathematics, hyperfunctions are generalizations of functions, as a 'jump' from one holomorphic function to another at a boundary, and can be thought of informally as distributions of infinite order. Hyperfunctions were introduced by Mikio Sato in 1958 in Japanese, (1959, 1960 in English), building upon earlier work by Laurent Schwartz, Grothendieck and others.

Traditional Chinese medicine contrast medium adjuvant used for B ultrasonic and preparation method thereof

The invention provides a traditional Chinese medicine contrast medium adjuvant used for B ultrasonic, which comprises the following materials in part by weight: 10-20 parts of bighead atractylodes rhizome, 10-20 parts of poria cocos, 10-20 parts of turmeric, 10-20 parts of tangerine peel, 10-20 parts of cortex magnoliae officinalis, 10-20 parts of radix aucklandiae, 10-20 parts of Rhizoma atractylodis, 10-20 parts of cuttlebone, 10-20 parts of calcined oyster shell, 10-20 parts of Chinese yam, 10-20 parts of charred triplet, 10-20 parts of myristica fragrans, 10-20 parts of gizzard pepsin, 10-20 parts of rhizome cyperi, 10-20 parts of codonopsis pilosula, 10-20 parts of combined spicebush root, 10-20 parts of eclipta, 10-20 parts of jasmine, 10-20 parts of baical skullcap root and 10-20 parts of field pennycress. The traditional Chinese medicine contrast medium adjuvant used for B ultrasonic provided by the invention not only can adapt to stomach hyperfunction type, but also can adapt to decreased stomach function type, and also can be applied to the mixed type of various flatulence and mucinosis, check time is short, imaging rate is high, and preparation process is simple and practical. The contrast medium adjuvant has no obvious toxic side effect and has prospect on further development research.
Owner:张洪英

Traditional Chinese medicine for treating thyroid hyperfunction companioned with diarrhea

Chinese traditional medicine for treating exophthalmic goiter in combination with diarrhea, wherein the recipe includes root of herbaceous peony 10g, nutgrass flatsedge rhizome 10g, white atractylodes rhizome 12g, coptis root 6g, root of pilose asiabell 15g, poria cocos wolf 10g, dried orange peel 6g, white hyacinth bean 10g, amomum fruit 3g, licorice root 6g, plantain seeds 20g, kudzuvine root 10g, banksia rose 10g, crude malt 15g, baked malt 15g, prunella spike 10g, thunberg fritillary bulb 15g, baikal skullcap root 8g, gentian root 12g, pericarpium trichosanthis 20g, grassleaved sweetflag rhizome 8g, schisandra fruit 10g, aspongopus 6g, spikenard 8g, magnolia bark 12g, tuber fleeceflower stem 9g and euphoria longan steud 15g. The Chinese medicament has simplified recipe, easy preparing process and low price.
Owner:尹克华

Quinoline derivatives as axl kinase inhibitors

Novel compounds which are inhibitors of receptor tyrosine kinases of the AXL receptor family are described herein. These compounds are suitable for the treatment or prevention of disorders associated with, accompanied by or caused by hyperfunction of a receptor of the AXL family. The compounds are suitable for the treatment of hyperproliferative disorders, such as cancer, particularly cancer metastases.
Owner:MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV

A drug for treating hyperthyroidism and its preparation method

The invention relates to a medicinal preparation for treating thyroid gland hyperfunction and process for its preparation, wherein raw materials include (by weight proportion) rough gentian, seabuckthorn fruit, selfheal and cape jasmine.
Owner:内蒙古复旦元和药业有限公司

Antidepressant application of composition of paeoniflorin and albiflorin and preparation method thereof

The invention discloses a pharmaceutical composition for the treatment of depression prepared by raw materials of paeoniflorin and albiflorin. The invention also discloses a preparation method of the pharmaceutical composition. The experiments prove that the pharmaceutical composition of the invention can obviously reduce the suspension tail immovability time of the mouse to be tested, from which the antidepressant function of the composition in the experiment can be inferred; the pharmaceutical composition of the invention can obviously withstand the temperature reduction of the mouse caused by the reserpine, from which the relevance of the antidepressan mechanism of the composition and the regulation of the monoamine transmitters can be inferred; and the pharmaceutical composition of the invention can significantly reduce the amounts of horizontal movement and vertical movement of the model rat, reduce the electric shock times in the training period and testing period of step down passive avoidance test, significantly reduce the CRH secretion of hypothalamus and ACTH secretion of hypophysis, and significantly reduce the CORT content in the blood, from which the antidepressant function of the pharmaceutical composition and one of the mechanisms of excessive hyperfunction suppression of HPA axis can be inferred.
Owner:张作光

Method of diagnosing an RTK-hyperfunction-induced disorder

The invention provides method of diagnosing a receptor tyrosine kinase (RTK)-hyperfunction-induced disorder or a genetic predisposition therefor in a mammal. The method comprises determining the presence of a nucleic acid encoding a mutated fibroblast growth factor receptor-4 (FGFR-4) protein in a nucleic acid sample from a mammal. The presence of a nucleic acid encoding a mutated FGFR-4 protein is indicative of an RTK-hyperfunction-induced disorder or a genetic predisposition therefor.
Owner:MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV

Management method of radiopharmaceutical

The present invention belongs to the field of hospital nuclear medicine department technology, is suitable for overall lifecycle management of radiopharmaceutical used in treatment of a nuclear medicine department thyroid cancer, treatment of thyroid uptake function hyperfunction and PET-CT and SPECT imaging, and provides a management method of radiopharmaceutical comprising transport warehousingmanagement, medicine subpackaging management and drug utilization management. The management method of the radiopharmaceutical achieves whole-cycle radiopharmaceutical monitoring, facilitates enhancement of radiation source supervision, avoids loss of the radiation sources and ensures public safety, management of an intelligent standing book facilitates management of improving the radiopharmaceutical to allow the management of nuclear medicine department drugs to be more ordered, and achieve digitlization and intelligence, and receiving and issuing management of drugs by employing special medicine cabinets further avoids human vulnerability and ensures safety of the radiation sources.
Owner:南京安石格心信息科技有限公司

Chinese herba preparation for recuperating and curing ovarian hypoplasia of young girls or adult women

A Chinese herba preparation for recuperating and curing ovarian hypoplasia of young girls or adult women is hot drink particles or a tea bag or a granular preparation consisting of kudzu roots, hawthorn, soya beans, red beans, black beans, fructus ligustri lucidi, eclipta alba, honeysuckle, Chinese rose, raw liquorice, dried tangerine or orange peels, fructus amomi, folium ginseng, dipsacus roots, eucommia bark, mistletoe, Japanese raspberry roots, winged euonymus twig, radix trichosanthis, pearl powder, yam flour, medicine beans and a packaging material. The Chinese herba preparation is used for preventing, recuperating and curing diseases including ovarian dysplasia or retardation of the young girls, ovarian hypofunction or hyperfunction, too little or too much estrogen secretion and ovarian and uterus dysgenesis of young married women, premature ovarian failure of older women, and barrenness of fertile women due to hypoplasia of ovum of ovarian, is used for moistening skin, retaining youthful looks and eliminating macula, and has the advantages that total effective rate of clinical recuperating and curing reaches 100% and the like.
Owner:李运乃

Urea compound, preparation method and application thereof

InactiveCN103172543APrevent or treat inflammatory responsesPrevent or treat hyperimmuneUrea derivatives preparationOrganic compound preparationHyperfunctionInflammation
The invention relates to an urea compound of the structure shown in a general formula I, a preparation method thereof, a drug composition containing the urea compound and an application of the drug composition in preparation of drugs used for treating inflammatory reaction, immunity hyperfunction and organ transplantation. R1-R7, X, Y and n in the general formula I disclosed in the invention are defined in the specification and claims.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI

Application of peimine in preparation of novel immunosuppressive agent

The invention relates to a novel application of peimine, and in particular relates to an application of peimine in preparation of a novel immunosuppressive agent. An experiment on the inhibiting effects of Kv1.2-Kv1.8 ion channels through peimine shows that the peimine can be combined with the Kv1.3 ion channel with relatively high selectivity, so that overexciting T lymphocyte is reduced; activation on the T lymphocyte is weakened, so that the activity of the T lymphocyte is lowered; the cellular immunity is finally lowered; and the effect on other potassium ion channels is weak. The peimine selectively penetrates through the inhibiting Kv1.3 ion channel, so that adverse effects caused by treatment of immune system function hyperfunction diseases such as scleroderma and lupus erythematosus can be reduced; and normal immunologic functions are not affected. Therefore, the peimine is of great significance on development of novel medicines.
Owner:OLIVE PHARMASOLUTINS LTD

Immunosuppressive cell preparation as well as preparation method and application thereof

The invention belongs to the technical field of biological medicine and particularly relates to an immunosuppressive cell preparation as well as a preparation method and an application thereof. The invention provides the immunosuppressive cell preparation and the application of the immunosuppressive cell preparation in preparation of SLE (systemic lupus erythematosus) preventing and treating drugs and further provides the preparation method of the immunosuppressive cell preparation. The immunosuppressive cell preparation comprises Treg cells, umbilical cord mesenchymal stem cell exosomes, cord blood mononuclear cells, umbilical cord blood plasma and a medically acceptable solvent. The immunosuppressive cell preparation has the beneficial effects as follows: the Treg cells and the umbilical cord mesenchymal stem cell exosomes play a role in inhibiting body immunity hyperfunction and balancing body immune system function firstly, the cord blood mononuclear cells play a role in immunoregulation, blood environment is improved, and the problem of immune system disorder is solved fundamentally.
Owner:广东颜值科技有限公司

Hyperfunction-inhibiting preparation and new preparing method

The present invention relates to a Chinese medicine composition and its preparation process. In particular, it relates to a Chinese medicine prescription for curing the diseases of exophthalmus due to goiter disease (hyperthyroidism), hyperhidrosis, vexation, palpitation, diabetes and tremor of limbs, etc, and its preparation process. Said invention can be made into dripping pills and soft capsule preparation.
Owner:FUKANGREN BIO PHARMA

Injection of serine protease inhibitor

The invention provides an injection of a serine protease inhibitor. The injection contains 0.05mg / ml to 30mg / ml of the serine protease inhibitor recombinant textilinin-1, a pH buffering agent, a surfactant, polyalcohol, amino acid and a bacteriostatic agent. The injection of the serine protease inhibitor has the advantages that the stability of protein medicine is improved; the preparation process is simple; the fibrinolysis-resistant treatment effect is good; and the injection can be used for treating and preventing fibrinolysis hyperfunction hemorrhage and blood loss caused by various reasons in clinics.
Owner:GRAND LIFE SCI (LIAONING) CO LTD

Technical formula and preparation method of tranexamic acid freeze-dried powder injection

The invention discloses a technical formula and a preparation method of a tranexamic acid freeze-dried powder injection. The tranexamic acid freeze-dried powder injection comprises tranexamic acid; a mixed solvent comprising 5-30% of tertbutyl alcohol and the balance of injection water in percentage by volume is used in the preparation process, and the concentration of tranexamic acid in the mixed solvent is 30-150 mg / ml. The preparation process comprises the following steps: measuring tertbutyl alcohol, adding injection water, mixing uniformly, cooling to 2-10 DEG C, keeping the temperature, adding tranexamic acid, stirring to enable tranexamic acid to be dissolved, filtering, filling, adding plugs, placing the mixture into discs, freeze-drying, pressing the plugs, unboxing, sealing opening through a cover, and packaging after passing the quality inspection to obtain the tranexamic acid freeze-dried powder injection. The tranexamic acid freeze-dried powder injection can be used for treating bleeding caused by acute and chronic, local or systemic primary fibrinolysis hyperfunction, bleeding caused by visceral trauma or operations, fibrinolytic bleeding, menorrhagia and other diseases.
Owner:SHENZHEN FONCOO PHARMACEUTICAL CO LTD

Water-Soluble Artemisinin Derivatives, Their Preparation Methods, the Pharmaceutical Compositions and the Use Thereof

Water-soluble artemisinin derivatives, their preparation methods, the pharmaceutical compositions containing the same derivatives and the use thereof are disclosed. The artemisinin derivatives have following formula I. It has been proved by pharmacological tests that these compounds and compositions have evident immuno-suppressive activities, and may be used in the preparation of novel immuno-suppressants for treating the diseases caused by hyperfunction of human immunity (e.g. the auto-immune diseases such as lupus erythematosus, rheumatoid arthritis, multiple sclerosis and the like), and for inhibiting the graft rejection after cell or organ transplantation.
Owner:JIANGSU ZUOYOU MEDICINE CO LTD

Trichosanthin effective epitope peptide fragment with immunosuppression effect and application thereof

ActiveCN103724409AHas anti-tumor application valueRetain effective biological activityAllergen ingredientsPlant peptidesSide effectAutoimmune diabetes
The invention relates to a trichosanthin effective epitope peptide fragment with an immunosuppression effect and application of the trichosanthin effective epitope peptide fragment, and discloses a trichosanthin effective epitope peptide PA and a trichosanthin effective epitope peptide PAQ, wherein an amino acid sequence of the trichosanthin effective epitope peptide PA is as shown in SEQ ID NO: 1; an amino acid sequence of the trichosanthin effective epitope peptide PAQ is as shown in SEQ ID NO: 4. The trichosanthin effective epitope peptide fragment PA and PAQ obtain effects in the experiment research on treatment of allogeneic mixed lymphocyte proliferation of immune response hyperfunction and obtains effects in the research on treatment on latent autoimmune diabetes in adults. According to the invention, the conventional method is broken through; parts with toxic or side effects are removed from a trichosanthin molecular structure and effective biological activity parts of the trichosanthin molecular structure are kept; a novel low-toxicity high-efficiency preparation which really can be used for treating various clinical diseases is developed.
Owner:SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE

Application of extractive of adinandra nitida leaves to preparation of anti-inflammatory analgesia medicament

The invention belongs to the technical field of medical treatment, and in particular relates to application of an extractive of adinandra nitida leaves to the preparation of an anti-inflammatory analgesia medicament. The toxicity and the anti-inflammatory analgesia pharmacodynamics evaluation are carried out on ethyl acetate parts of the adinandra nitida leaves by taking a mice acute toxicity test as a medicine toxicity index, taking a mice hot-plate test and a rat toe mechanical stabbing pain test as analgesia pharmacodynamics indexes, taking a test on the glacial acetic acid-induced capillary permeability hyperfunction of mice peritoneal cavities, a test on the dimethylbenzene-induced swelling of mice ears and a test on the cotton balling granulation of rats as anti-inflammatory pharmacodynamics indexes. The results show that the extractive has the advantages of low toxicity and very good anti-inflammatory analgesia activity and can be applied to the preparation of anti-inflammatoryanalgesia medicaments or auxiliary medicaments.
Owner:玉林市中医医院

Pharmaceutical composition for treating cancer and preparing method thereof

InactiveCN106177391AGreat tasteQuick and obvious healing effectAntineoplastic agentsPlant ingredientsReady to eatCancer cell
The invention relates to a pharmaceutical composition for treating cancer and a preparing method thereof. The composition is prepared from 3.6-5.5 parts of coptidis rhizome, 7.2-9.9 parts of fructus forsythia, 3.6-5.5 parts of cortex phellodendri, 4.5-6.6 parts of licorice root, 6.3-8.8 parts of radix scutellariae, 7.2-11 parts of radix trichosanthis, 4.5-6.6 parts of fructus gardenia, 8.1-11 parts of radix scrophulariae, 4.5-6.6 parts of rhizoma anemarrhenae, 6.3-8.8 parts of radix rehmanniae preparata and 3.6-5.5 parts of radix platycodi. The preparing method comprises the steps of soaking the raw materials in honey for 5-10 h, and then conducting drying and smashing. The pharmaceutical composition can clear heat, purge intense heat, relieve internal heat or fever, promote blood circulation to remove blood stasis and eliminate lumps, it is proved through clinical verification that treatment effect is remarkable, cure rate is as high as 85%, and relapse rate is low. The pharmaceutical composition does not need to be decocted, is ready to eat, has a good taste, and can activate the detoxifying function of internal organs, inhibit hyperfunction of cancer cells, improve immunity and help patients regain health.
Owner:姜连杰

Ovary function associated protein, and preparation and use thereof

The invention discloses an ovarian function-related protein. The ovarian function-related protein is protein consisting of amino acid sequences shown by SEQ ID No.2 or derived protein with the same or similar activity and formed by substituting / or deleting and / or adding the amino acid sequences shown by the SEQ ID No.2 by one or more amino acid sequences. The invention further discloses an encoding gene of the protein, a recombinant expression carrier containing the gene, a transformant containing the recombinant expression carrier, and a preparation method of the protein and an antibody thereof. The ovarian function-related protein possibly takes part in cell signal transduction and mature regulation of ova, plays a certain effect during a fertilization process, and shows potential of being further developed into a novel diagnostic reagent or a preventive drug for diseases caused by hypofunction, deletion or hyperfunction of the protein.
Owner:ARMY MEDICAL UNIV

Heterocyclyl-substituted indoxaphthalenone derivatives and their medical use

The invention relates to a heterocyclic radical-substituted indolonaphthalenone derivative and its uses in medicines. Concretely, the invention relates to a compound having tyrosine kinase a n a p l a s t i c l y m p h o m a k i n a s e (ALK) selective inhibition activity and its pharmaceutically acceptable salt or solvate, a preparation method of the compound and its pharmaceutically acceptable salt or solvate, and uses of the compound and its pharmaceutically acceptable salt or solvate in preparation of drugs for preventing or treating biological in-vivo ALK-related diseases with abnormal cell proliferation, morphologic change and / or motion function hyperfunction, in preparation of drugs for preventing or treating angiogenesis or cancerometastasis-related diseases and especially in preparation of drugs for treating or preventing tumor growth and transfer.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI

Application of nicotinamide mononucleotide ribose phosphate transferase inhibitor

The invention discloses an application of a nicotinamide mononucleotide ribose phosphate transferase inhibitor. The nicotinamide mononucleotide ribose phosphate transferase inhibitor can effectively prevent or treat thrombocyte hyperfunction, and blood hypercoagulative state or thrombi, has the advantages of favorable curative effect, small side effect and high safety, and has an important meaning for treating coagulation hyperfunction diseases.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY

Compound liniment for treating autoimmune disease

The compound liniment for curing autoimmune disease is formed from matrix and effective component, said matrix comprises 15-25% of effective component which comprises artificial musk and levamisole, the mass ratio of both them is 1:1.2. The artificial musk possesses strong systemic property and strong action of relieving inflammation, and the levamisole is an immunodepressant, and can suppress immunological hyperfunction, so that said liniment possesses the obvious therapeutic effect for curing rheumatoid arthritis, lupus sebaceus and ankylosing spondylitis, etc.
Owner:沈祖光

Trichosanthin effective epitope peptide fragment with immunosuppression effect and application thereof

ActiveCN103724409BHas anti-tumor application valueRetain effective biological activityAllergen ingredientsPlant peptidesSide effectAutoimmune diabetes
The invention relates to a trichosanthin effective epitope peptide fragment with an immunosuppression effect and application of the trichosanthin effective epitope peptide fragment, and discloses a trichosanthin effective epitope peptide PA and a trichosanthin effective epitope peptide PAQ, wherein an amino acid sequence of the trichosanthin effective epitope peptide PA is as shown in SEQ ID NO: 1; an amino acid sequence of the trichosanthin effective epitope peptide PAQ is as shown in SEQ ID NO: 4. The trichosanthin effective epitope peptide fragment PA and PAQ obtain effects in the experiment research on treatment of allogeneic mixed lymphocyte proliferation of immune response hyperfunction and obtains effects in the research on treatment on latent autoimmune diabetes in adults. According to the invention, the conventional method is broken through; parts with toxic or side effects are removed from a trichosanthin molecular structure and effective biological activity parts of the trichosanthin molecular structure are kept; a novel low-toxicity high-efficiency preparation which really can be used for treating various clinical diseases is developed.
Owner:SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE

Quinoline derivatives as AXL kinase inhibitors

Novel compounds which are inhibitors of receptor tyrosine kinases of the AXL receptor family are described herein. These compounds are suitable for the treatment or prevention of disorders associated with, accompanied by or caused by hyperfunction of a receptor of the AXL family. The compounds are suitable for the treatment of hyperproliferative disorders, such as cancer, particularly cancer metastases.
Owner:MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN EV

Elsholizia extract capsule for treating diarrhea and its prepn

The invention discloses a capsule preparation of the volatile oil of fenugreek and a quality control method thereof. The capsule preparation of the volatile oil of the fenugreek has anti-virus, anti-bacterial, anti-inflammatory, antidiarrheal, pain-relieving and antipyretic effects, and can inhibit gastrointestinal hyperfunction .
Owner:张瑞祥

A palm type rehabilitation brace and its use method

The invention discloses a palm-type rehabilitation brace. The palm-type rehabilitation brace comprises a brace body, a palm brace section of the brace body, a fixing section connected to the jaw part of the palm brace section and bent to the back of the hand, and also comprises a fixing mechanism used for mounting daily articles for carrying out the corresponding upper limb function operations, wherein the fixing mechanism is arranged on the surface of the inner palm part of the palm brace section, and comprises a plurality of velcro straps longitudinally and horizontally arranged, and the daily articles are fixed by adopting the longitudinal and horizontal velcro straps. The palm-type rehabilitation brace is suitable for being worn by patients without the obvious hyperfunction of the hand muscular tension or with low hyperfunction of hand muscular tension, is used for assisting the patients in carrying out some simple upper limb function operations, can arouse the interest of the patients in wearing the brace for a long term, and is also beneficial for the patients in using the residual wrist, elbow and shoulder functions of the upper limb, so that the rehabilitation effect is achieved.
Owner:SHANGHAI PUTUO DISTRICT PEOPLES HOSPITAL

Palm-type rehabilitation brace and rehabilitation method adopting same

The invention discloses a palm-type rehabilitation brace. The palm-type rehabilitation brace comprises a brace body, a palm brace section of the brace body, a fixing section connected to the jaw part of the palm brace section and bent to the back of the hand, and also comprises a fixing mechanism used for mounting daily articles for carrying out the corresponding upper limb function operations, wherein the fixing mechanism is arranged on the surface of the inner palm part of the palm brace section, and comprises a plurality of velcro straps longitudinally and horizontally arranged, and the daily articles are fixed by adopting the longitudinal and horizontal velcro straps. The palm-type rehabilitation brace is suitable for being worn by patients without the obvious hyperfunction of the hand muscular tension or with low hyperfunction of hand muscular tension, is used for assisting the patients in carrying out some simple upper limb function operations, can arouse the interest of the patients in wearing the brace for a long term, and is also beneficial for the patients in using the residual wrist, elbow and shoulder functions of the upper limb, so that the rehabilitation effect is achieved.
Owner:SHANGHAI PUTUO DISTRICT PEOPLES HOSPITAL

Preparation method, product and application of lactobacillus whole peptidoglycan with effect for resisting beta-lactoglobulin hypersusceptibility

The invention discloses a preparation method, a product and application of lactobacillus whole peptidoglycan with an effect for resisting beta-lactoglobulin hypersusceptibility and relates to a microemulsion preparation prepared from the lactobacillus whole peptidoglycan obtained in the invention. The microemulsion preparation is prepared by the following steps of: with the lactobacillus whole peptidoglycan as a main effective component, heating the whole peptidoglycan, an oil phase, a surfactant, a cosurfactant and water at 70DEG C by stirring to enable the whole peptidoglycan to be completely dissolved; and uniformly mixing to obtain a semitransparent emulsion product with the liquid drop diameter of 30-45nm. After the lactobacillus whole peptidoglycan microemulsion preparation is orally taken to enter the interior of the body, lymphocyte can be effectively stimulated to secrete IL-12 and IFN-gamma; the IL-4 level is reduced; excessive hyperfunction of Th2 cells is reversed; and the lactobacillus whole peptidoglycan microemulsion preparation plays an important role of inhibiting beta-lactoglobulin allergic inflammation mediated by IgE and has potential application values for developing an immunopotentiator with antiallergic performance and the like.
Owner:天津众品科技有限公司
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