72 results about "Morphologic change" patented technology

The invention relates to five-membered heterocycle pyrimidine compounds, their pharmaceutical acceptable salt or pharmaceutical acceptable solvate and a preparation method thereof. The five-membered heterocycle pyrimidine compounds possess a c-Met inhibitory activity and have a structure as shown in the general formula 1. The invention also relates to a drug combination which contains the compounds and applications of the compounds in preparation of drugs used for prevention and treatment of in vivo Hepatocyte Growth Factor Receptor (HGFR) related abnormal cell proliferation, morphologic change and hyperkinesis associated diseases, angiogenesis or cancer metastasis associated diseases, and especially for prevention and treatment of tumor growth and metastasis.

The present invention exploits a visual rendering of heart sounds and models the morphological variations of audio envelopes through a constrained non-rigid translation transform. Similar heart sounds are then retrieved by recovering the corresponding alignment transform using a variant of shape-based dynamic time warping.

The invention relates to a method for apperceiving and reconstructing a non-vision structural form of a near space vehicle model. The method comprises the following steps: on the basis of a distributed embedded dispersed bragg fiber grating sensing array, sensing and detecting strain information of each measuring point of a test model, and utilizing a certain curvature conversion algorithm to convert the strain information into curvature information; on the basis of a curvature interpolation, calculating the related coordinate value of each point of wings and frame of the test model according to a three-dimensional space curve fitting algorithm of orthogonal curvature information; utilizing a coordinate fuse algorithm to obtain an absolute coordinate value of each point of the model; and lastly, reconstructing the deformation state and the low-frequency vibrating form of the test model according to a computer graphic processing technology and realizing the three-dimensional visual real-time display for the change in the model form. An experimental system for the method comprises a simulated near space vehicle model, a fiber grating network analyzer with a network service function, a high-performance computer and a display, wherein the fiber grating sensing array is embedded into the surface of the simulated near space vehicle model.

The invention provides a screen control method and a mobile terminal. The screen control method is applied to the mobile terminal with a flexible screen. The screen control method comprises the following steps of: detecting a continuous operation time length of operating the mobile terminal by a user; if the detected continuous operation time length achieves a preset first time length, displayingfirst reminding information; and if the detected continuous operation time length achieves the second preset time length, controlling a preset screen area of the flexible screen to bend, wherein the first prompt information is used for reminding the user of morphologic change information of the flexible screen after a preset time length. According to the screen control method, the problem that thetime of operating the mobile terminal cannot be strictly controlled when users use the mobile terminal in the prior art is solved.

The invention discloses a flexible electronic device. The flexible electronic device comprises a flexible display screen and a support part which are arranged in a stacked mode; the support part can be bent to deform to enable the flexible electronic device to be bent to deform; the flexible display screen can be slidably arranged on the support part relative to the support part; in the morphologic change process of the flexible electronic device, the flexible display screen slides relative to the support part. According to the flexible electronic device, in the morphologic change process of the flexible electronic device, the flexible display screen slides relative to the support part to be prevented from being pulled by the support part, damage can be avoided, and the service life of the flexible electronic device is prolonged.

The invention discloses fluorochrome for cytolysosome positioning and a preparation method and application thereof. The preparation method of the fluorochrome compound includes the steps that a benzophenone derivative containing methyl substituents is reacted under the catalysis of Zn / TiC14, an obtained product and N-bromosuccinimide are subjected to a bromination reaction, then a product is reacted with morpholine, and the tetraphenyl ethylene derivative stain containing morpholine groups is obtained. The preparation method is easy to implement, raw materials are easy to get, and reaction conditions are mild. The obtained fluorochrome contains tetraphenyl ethylene fluorescence groups capable of gathering the activity of inducing fluorescence emission and can be used for performing specific staining on all kinds of cytolysosome. The fluorochrome has the advantages of being small in cytotoxicity, stable in cell metabolism resistance, good in photobleaching resisting effect and the like and hardly affects normal physiological activities of cells, and a new method is provided for observing the morphologic changes of cytolysosome for a long time. The fluorochrome can be widely applied to monitoring the morphology of cytolysosome, observing the apoptosis process and the like.

The invention discloses a passivating agent for mercury-polluted soil remediation, which comprises bentonite and diammonium hydrogen phosphate, wherein the using amount of the bentonite is 1-6% of the weight of the soil, and the using amount of the diammonium hydrogen phosphate is 0.1-3% of the weight of the soil. The bentonite is sodium-based bentonite, and has a particle size of 200 meshes. The passivating agent for mercury-polluted soil remediation of the invention can significantly reduces the total mercury content of edible parts of crops, while other treatment methods have no obvious reduction trend. By analyzing the morphologic change characteristics of soil mercury before and after remediation, it is found that the passivating agent for mercury-polluted soil remediation of the invention significantly reduces the contents of effective-state mercury (dissolved-state, exchangeable-state, and special adsorption-state mercury) and ferro-manganese oxidation-state mercury in soil, and the contents of organically combined-state mercury and residue-state mercury are not changed significantly.

The invention discloses a surveying and mapping method based on municipal engineering, which includes the steps of: 1) installation; 2) fine tuning: selecting different positions, and performing observation by moving a leveling instrument, by means of a traveling device, to a predetermined position, and performing fine tuning to the leveling instrument through the observation results at differentpositions to level the leveling instrument; 3) ground surface static surveying and mapping: pre-setting a plurality of different points in a surveying zone, and moving the leveling instrument to the preset points to collect signals of surrounding environment, and mapping figures of measurement results of the leveling instrument at the preset points, and performing overall analysis to the figures with combination of coordinate reference of the preset points, thereby acquiring geometric position information of buildings and ground surface morphologic change in the surveying zone; 4) ground surface dynamic surveying. The invention relates to the technical field of surveying and mapping methods. According to the surveying and mapping method, position of a surveying and mapping device can be adjusted conveniently, and accumulated dust on the leveling instrument can be removed effectively and dust on connection positions can be removed completely, so that the apparatus can slide smoothly.

The invention relates to the technical field of biomedicine, in particular to cell cryopreservation fluid and application thereof. The cell cryopreservation fluid disclosed by the invention is prepared from the following components: dimethyl sulfoxide, human albumin, low-molecular dextran, a human mesenchymal stem cell exosome, hydroxyethyl starch and a basal culture medium. Cells cryopreserved and revived by using the cell cryopreservation fluid are high in viability, the morphologic change is not large, differentiation cannot be caused during culture, and surface antigen detection accords with the standard; in addition, by optimizing a cell cryopreservation scheme, death of a large amount of cells caused by ice crystal formation during a cryopreservation process of the cells can be avoided as much as possible, a cryopreservation system is optimized, revived cells can be directly fed back to a human body, and animal derived serum is not added, animal derived virus infection is avoided; the cell cryopreservation fluid is wide in application, and the technical problem that the cell viability after the reviving of the cells which are cryopreserved by an existing cell cryopreservationsystem is not high is solved.

The invention provides a method for establishing a micro-fluidic chip based human heart model. A micro-fluidic chip mainly comprises a cell inlet pool, channels, a cell culture chamber and an outlet pool, wherein the cell culture chamber is connected to the cell inlet pool and the cell outlet pool through straight channels; and the cell culture chamber has a structure having repeated hexagonal bulges. The method for establishing a human heart model comprises the following steps: (1) directionally differentiating hiPSC into myocardial cells; (2) modifying the chip; (3) inoculating and culturing cells in the chip; and (4) establishing the human heart model. The model is used for observing representations of cell activity investigation and function changes in the chip, and can be used for human heart auxology researches and drug cardiotoxicity. The micro-fluidic chip based human heart model is used for observing morphologic changes and arrangement of myocardial cells having a micro-structural surface under the perfusion condition at different flow-speeds, especially for the influence of blood flow shearing force and matrix surface microstructure on the myocardial cell developmental maturity in the heart developing process.

The invention discloses a strain measuring method based on Moire fringe phase analysis. The method includes the steps: generating the mechanism of a Moire fringe structure by means of a grating structure, converting the strain of an object structure into a morphologic change of Moire fringes, and determining the strain of the object structure through a phase analysis mode. During a strain measuring process, parallel light vertically enters an object grating mark G1, a grating is imaged on the surface of the object structure through a left dual-telecentric system (1), a right dual-telecentric system (2) enables the grating image on the surface of the object structure to be imaged again in a detection grating mark G2 position, and the two grating marks are overlapped after space imaging to form Moire fringe distribution. The strain of an object causes the phase shift of Moire fringes, so the strain of the object is calculated through a phase analysis algorithm. The characteristics are that the method is contact-free, is high in measuring precision and high in technical adaptability, is highly practical, etc.

The invention provides metastatic tumor deletion protein small-molecule cyclopeptide, derivatives or salts thereof, a preparation method for the metastatic tumor deletion protein small-molecule cyclopeptide, the derivatives or salts thereof and an application of the metastatic tumor deletion protein small-molecule cyclopeptide, the derivatives or salts thereof in preparation of antitumor medicaments. The metastatic tumor deletion protein small-molecule cyclopeptide is low in molecular weight, high in stability and very low in toxicity and can enter cells through cell membranes to inhibit endocytosis of tumor cells and interfere morphologic change of the cell membranes and conduction of relevant antitumor signals by inhibiting dimerization of Mtss1 protein, so that cell proliferation and growth caused by tumor stimulating factors such as epidermal growth factors EGF, platelet derived growth factor PDGF or sonic hedgehog (shh) factors are weakened, wherein the in-vitro inhibition activity of nanomole-scale inhibitor-protein can remarkably inhibit the endocytosis of the cells after the inhibitor-protein is directly added into cell culture fluid without being transfected or packaged by lipidosome.

The invention provides a measurement method for the migration rule of pre-crosslinked gel particles in a rock microscopic pore throat. The method includes: preparing a pre-crosslinked gel particle solution; building a visual measurement platform, and installing a rock microscopic pore throat model; utilizing a visual image acquisition and analysis system and a real-time pressure measurement and acquisition system respectively for real-time and visual capture and measurement of the morphologic change and pressure change of pre-crosslinked gel particles when passing the rock microscopic pore throat model; analyzing the changes to acquire microscopic seepage parameters of the pre-crosslinked gel particles when passing the rock microscopic pore throat model, and performing autoregression of amathematical model corresponding to the morphologic change and pressure change of the particles; and analyzing the migration rule of the pre-crosslinked gel particles in the rock microscopic pore throat, thus realizing integrated measurement of deformation, blockage, breakage and other morphologic change characteristics and real-time pressure change situation involved when the pre-crosslinked gelparticles pass through the rock microscopic pore throat.

The invention discloses a single stem plant digitalized construction method based on a growth model and relates to the technical field of agricultural information. The method comprises the following steps of (1) preprocessing experiment observation data and establishing the growth model of a single stem plant through statistic package for social science (SPSS) statistical software; (2) establishing an assimilation reallocation model based on a plant structure; (3) reconstructing plant morphologic change and establishing a single stem plant digitalized model; and (4) achieving digitization of a single stem plant. A plant growth model is obtained through experiments, a plant digitalization model capable of reflecting plant growth mechanism accurately is established and computer simulation of the plant growth process is achieved due to the model so that plant growth and development in different external environments can be forecasted due to a plant digitalization result.

A system for dynamically adjusting treatment angle under tension to accommodate variations in spinal morphology during spinal decompression therapy is provided. It provides a tensioning device including a patient-positioning means, a tension-producing actuator, a positioning device, a patient interface device, a control system and a display. The control system with feedback on the resultant tension vector applied to patient spine operationally configured to allow for adjustment of either tension producing actuator position, patient position, or both while applying tension to the patient spine during non-therapeutic tension levels. The control system automatically adjusts tension producing actuator work levels such that the resultant tension vector magnitude remains ideally constant during adjustment of resultant tension vector angle, reducing the risk of eliciting paraspinal muscle contraction due to changes in resultant tension vector magnitude.

The invention discloses a cell non-contact culture method based on a micro-fluidic chip. According to the method, the pressure, which is generated by the height difference between a sample inlet and a sample outlet, is utilized to drive cells into a main channel; due to the laminar flow characteristic of micro fluid, different species of cells are individually fixed on specific areas of the main channel, different cells are not contacted with each other, but in a same culture environment; the cell biological behaviors such as morphologic change of cells, cell migration, and the like, can be directly observed by a microscope; and novel thoughts and a novel technology are provided for the research on the interactions between cells. The provided micro-fluidic chip cell co-culture model realizes the different species cell non-contact co-culture, and has the characteristics of simpleness, practicality, visualization, microminiaturization, low manufacturing cost, and little using amount of reagents and samples.

The invention discloses a reward-punishment weight type simulation sequence similarity analysis method in consideration of morphologic change, and belongs to the technical field of the power system simulation. The method comprises the following steps: acquiring to-be-analyzed simulation data, acquiring time sequences in same dimension comparison after performing averaging processing on the initialdata, and giving out the entire similarity of the software type, and computing the entire change tendency similarity of two groups of simulation data by using the slop change of the adjacent time interval data points of the simulation sequence; obtaining the analyzed and compute weight at each point by appropriately rewarding or punishing the selected initial weight according to the amplitude proportion, and finally obtaining a formula for computing the similarity of two groups of simulation sequences. The simulation result data of different software is processed from a quantitative angle, any time sequence capable of acquiring the software simulation result of different power systems can be analyzed by using this method, and the method is further applicable for the similarity analysis ofthe offline simulation and the online real-time data.

The invention provides a method for reprogramming spinal marrow astrocytes into motor neurons through induction. The method comprises steps as follows: (1) primary rat astrocytes are subjected to pure culture; (2) 7 small molecule drugs including SB431542, LDN-193189, RA, bFGF, Purmorphamine, Forskolin and VPA are selected according to substances required in the stages of neuron induction and motor neuron formation and development, and the astrocytes are induced and reprogrammed in vitro through the small molecule drugs; (3) the reprogramming and differentiation conditions of the astrocytes to the motor neurons are analyzed through observation of morphologic change of cells and methods of chemical technology analysis of immunofluorescent cells, real-time fluorescent quantitative PCR analysis and statistical analysis. The rat astrocytes can be successfully induced and reprogrammed into the motor neutrons in vitro through small molecular drug composition, and the transdifferentiation exceeds 75%; in-situ direct reprogramming of the astrocytes to the neurons is a possibly comparatively feasible thought in SCI (spinal cord injury) repairing and functional reconstruction treatment.

A bone repair apparatus is provided where a biologically compatible structure has a compound carried on the structure that mimics collagen binding to cells. Living cells derived from fibroblasts are carried on the structure and display at least one morphologic change consistent with an osteogenic phenotype. The preferred method for practicing the invention includes harvesting a quantity of fibroblasts from a patient in need of a bone graft, growing the tissue under cell growth conditions, and seeding at least some cells of the cultured tissue on the biologically compatible structure with the collagen mimic thereon. The culture tissue cells are seeded on the structure and incubated under cell growth conditions, which results in the differentiation of the cells to bone-like cells and thus provides a tissue engineered apparatus ready for use as a bone graft.

The invention discloses a method for measuring the length of a heat-affected zone of 617 nickel-based alloy. The method comprises the steps that a metallographic specimen is prepared, and the length of the heat-affected zone of the 617 nickel-based alloy is measured by observing the metallographic specimen under a microscope; the boundary line of the heat-affected zone and a 617 nickel-based alloy basic material is determined by observing the morphologic changes of carbides in a near weld zone of a welding joint of the metallographic specimen through the microscope, that is to say, by combining the characteristic changes around the carbides, and then the distance between the boundary line and a fusion line is obtained, that is to say, the length of the heat-affected zone is obtained. According to the method, the problem that the length of the heat-affected zone of the 617 nickel-based alloy is difficult to measure is solved; meanwhile, a simpler and more accurate measurement method is provided, and help is provided for scientific research in the field.

The invention relates to the field of gas-sensitive film preparation, and particularly relates to a gas-sensitive film sensitive to ethanol and acetone and a preparing method thereof. The method includes firstly coating a substrate with a thermoplastic polymer nanometer fibrous suspension, drying the substrate to form a thermoplastic polymer film on the surface of the substrate, tearing off the thermoplastic polymer film from the substrate, preparing a nano-microcrystalline cellulose suspension through hydrolyzing cellulose with an acid, coating the thermoplastic polymer film with the nano-microcrystalline cellulose suspension, and drying the product to obtain the gas-sensitive film. Whether ethanol vapor or acetone vapor overflows or not can be determined through macroscopic morphologic changes of the prepared gas-sensitive film, and the prepared gas-sensitive film can response to ethanol vapor and acetone vapor.

The invention discloses a microscopic endoscope system which comprises an illuminating unit, a camera shooting and image processing unit, an endoscope microscopic probe, an optical fiber image transmitting bundle and an image output and illumination input unit. The illuminating unit provides illumination light for an endoscope; the camera shooting and image processing unit shoots a body tissue image and processes the image; the endoscope microscopic probe enters the body cavity through a pincers channel hole of the endoscope system and carries out microimaging on the target tissue; the optical fiber image transmitting bundle transmits a target image formed through the endoscope microscopic probe; the image output and illumination input unit couples illuminating light output by the illuminating unit into the optic fiber image transmitting bundle and inputs the image transmitted out by the optic fiber image transmitting bundle into the camera shooting and image processing unit. The system solves the problems that an endoscope system in the prior art is low in imaging override, and the morphologic change and the cell microstructure of the tissue can not be observed.

The invention provides 3-amino-benzo five-membered heterocyclic compounds having the structure represented by the general formula (I) and pharmaceutical acceptable salts or pharmaceutical acceptable solvates thereof, and a preparation method and an application thereof in preparation of drugs for inhibiting the activity of tyrosine kinase c-Met, an application thereof in preparation of drugs for prevention or treatment of diseases related to cell abnormal proliferation, morphologic changes and hyperkinesia which are related to hepatocyte growth factor receptor (c-Met) in biological bodies and diseases related to angiogenesis or cancerometastasis, and particularly an application thereof in preparation of drugs for treatment or prevention of tumor growth and metastasis. Active separation of c-Met and VEGFR2 by the target compounds is achieved, and moreover, the better c-Met inhibitory activity is retained.

The invention discloses a method and device for processing a normal map, a storage medium, a processor and a terminal. The method includes obtaining an initial normal map and a plurality of change normal maps according to an example basic model, wherein each of the plurality of change normal maps contains morphologic change data evolving from the example basic model; according to a first weight value set for each of the plurality of change normal maps in advance, performing synthesis processing on the initial normal map and the plurality of change normal maps to obtain a synthesized normal map; and performing interpolation processing between the initial normal map and the synthesized normal map, and rendering and displaying an interpolation result. The method provided by the invention solves the technical problem in related technologies that a provided game role skin manifestation mode is relatively large in calculation amount and relatively high in logic complexity.

The invention relates to a medicament based on rosmarinic acid and application thereof in treating Parkinson's disease. According to the formula of the medicament, the medicament comprises rosmarinic acid and sodium citrate with the molar concentration thereof being 1:104 to 1:1011. The medicament achieving the effect of neuroprotection in MES23.5 dopaminergic cells can obviously relieve the reduction in the survival rate of the MES23.5 cells caused by the induction of neurotoxin, i.e., 6-hydroxydopamine (6-OHDA) or 1-methyl-4-phenylpyridine cations, obviously relieve the reduction in the mitochondrial membrane potential of the cells caused by the induction of neurotoxin, i.e., 1-methyl-4-phenylpyridine cations and the generation of ROS (reactive oxygen species) substances and obviously improve the morphologic changes of nuclei caused by the induction of neurotoxin, i.e., 6-hydroxydopamine (6-OHDA) or 1-methyl-4-phenylpyridine cations, thereby achieving the effects of neuropretection, oxidation resistance and apoptosis resistance. The medicament of the invention having low toxicity and side effect has significant application prospect and actual value for the development into a novel anti-Parkinsonism natural medicament.

The invention relates to a preparing method for asymmetric hollow microspheres based on polymer template particles. According to the method, the quantity of a dispersing agent and seed monomers is adjusted so that the dimension size of a dispersing phase before polymerization can be changed, the dimension of the polymer template particles is adjusted, and thus the dimension of the final hollow microspheres is controlled. The hydrolysis rate of silane can be controlled by adjusting the charging proportion of ethyl alcohol / water, so that the time for the sol-gel process in the second step is controlled, and the hollow microspheres with morphologic changes can be prepared. Soap-free emulsion polymerization is adopted in the method, operation is easy, experiment conditions are mild, and the asymmetric hollow microspheres with different microstructures can be efficiently prepared and easily separated and processed further, and great significance is achieved on the research and application of the asymmetric hollow microspheres. The synthetic process is easy and convenient to implement and capable of easily achieving mass production, has universality and is suitable for other polymer systems.

The invention discloses a medicament of a 1,3,4-oxadiazole containing pyrazole compound prepared for treating tumor, which comprises 1,3,4-oxadiazole containing pyrazole compound, and a pharmaceutical acceptable salt thereof as shown in the formula (I), wherein in the formula (1), R1, R2 and R3 refer to H, halogen, C1-C6 alkyls, aryl, C1-C4 alkoxys or nitryls; n refers to 1, 2, 3, or 4; and the halogen is fluorine, chlorine, bromine or iodine. The compound or pharmaceutical acceptable salt thereof is an acid added salt formed by the compound shown in the formula (I) and the following acids: a hydrochloric acid, a sulfuric acid, a benzenesulfonic acid or a p-toluenesulfonic acid. The medicament comprises a solvate of the compound shown in the formula (I) and water, ethanol, ethyl ether or acetone. The medicament has an inhibitory effect on human liver cancer cells. The compound shown in the formula (I) is a drug which can be used for preventing and treating related diseases such as various abnormal cell proliferation and morphologic changes and the like, and especially used for treating and preventing tumor diseases.

The invention discloses a dynamic bidirectional-stretch in-situ online-observation cell biomechanics loading device. The loading device comprises a base film for the growth of an adherent cell used for being observed; two fixing clips for clamping the two sides of the base film respectively, two displacement support arms for supporting the fixing clips respectively, and a driving part, wherein the fixing clips are movably arranged on a rail, and the driving part is used for driving the displacement support arms to perform symmetrical opposite-direction displacement on the rail so as to conduct bidirectional-stretch on the base film. According to the invention, by conducting the stretch with a certain frequency and a certain range on the cell growing on the biocompatible film, morphologic change, cytoskeleton reorganization, signal transduction and other responses of the cell in different action times can be observed.

The invention is applicable to the field of medical treatment device and provides a capsule gastroscope magnetic control system and a capsule gastroscope magnetic control method. The system comprises a magnet body; a magnet gesture adjusting device, which is in driving connection with the magnet body, and used for adjusting the magnet gesture so as to adjust the gesture of the capsule gastroscope; a magnet position adjusting device, which is in driving connection with the magnet body, and used for adjusting the magnet body position so as to further adjust the position of the capsule gastroscope from the horizontal direction in relative to the capsule gastroscope. The control method avoids the equipment constriction to human body; meanwhile, the standing method of a human body avoids the morphologic change by the stomach pressing and influence on controlling the capsule gastroscope; besides, the method of controlling the capsule gastroscope from horizontal direction is easier to control the capsule gastroscope from the side direction of the human body, and can be controlled only by rotating the human body, thus it is easier to comprehensively check the capsule gastroscope image.