Five-membered heterocycle pyrimidine compounds, preparation method and application thereof

A technology for five-membered heterocycles and compounds is applied to a class of five-membered heterocyclic pyrimidine compounds and the fields of their preparation and use, and can solve problems such as limited structure
CN102464667AInactive Publication Date: 2012-05-23SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Publication Date
2012-05-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to five-membered heterocycle pyrimidine compounds, their pharmaceutical acceptable salt or pharmaceutical acceptable solvate and a preparation method thereof. The five-membered heterocycle pyrimidine compounds possess a c-Met inhibitory activity and have a structure as shown in the general formula 1. The invention also relates to a drug combination which contains the compounds and applications of the compounds in preparation of drugs used for prevention and treatment of in vivo Hepatocyte Growth Factor Receptor (HGFR) related abnormal cell proliferation, morphologic change and hyperkinesis associated diseases, angiogenesis or cancer metastasis associated diseases, and especially for prevention and treatment of tumor growth and metastasis.
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Description

technical field

[0001] The present invention relates to a class of five-membered heterocyclic (thiophene, furan, pyrrole) pyrimidine compounds with c-Met inhibitory activity and their pharmaceutically acceptable salts or pharmaceutically acceptable solvates. The preparation method includes The pharmaceutical composition of the compound, and the preparation of these compounds are used to prevent or treat diseases related to abnormal cell proliferation, morphological changes and hyperkinetic function related to the hepatocyte growth factor receptor (HGFR) in the organism, as well as diseases related to vascular Use of medicines for neonatal or cancer metastasis-related diseases, especially medicines for treating or preventing tumor growth and metastasis. Background technique

[0002] Hepatocyte growth factor (hepatocyte growth factor, HGF), also known as scatter factor (Scatterfactor, SF), is the endogenous ligand of c-Met, a family of tyrosine kinase receptors. Proto-oncogen...

Claims

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