Traditional Chinese medicine contrast medium adjuvant used for B ultrasonic and preparation method thereof

The technology of a contrast agent and traditional Chinese medicine is applied in the field of traditional Chinese medicine contrast agent and its preparation, which can solve the problems of strong gastric acid reaction, inability to use, no therapeutic effect, etc., and achieves the effects of simple preparation process, short inspection time and no allergic reaction.

Inactive Publication Date: 2011-05-25
张洪英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, for B-ultrasound gastrointestinal imaging aids, the prior art has recorded that the imaging aids prepared by mixing 80% of cuttlebone fine powder and 20% of nutmeg 100-mesh fine powder have astringent and acid-relieving properties for gastrointestinal diseases. It is effective, but the disadvantage is that after the patient takes the contrast agent, the strong echo light spot is insufficient, the reflection effect is not good, and the layer of the stomach wall is not clear; after the patient takes the contrast agent, the gastric acid reaction is strong, and there is pain and discomfort. It is not conducive to contrast-enhanced ultrasound of the gastrointestinal tract, and this contrast agent cannot be used for patients with gastric bleeding
The prescription uses bitter barrels, which taste extremely bitter, so sucrose is used to improve the taste, and sucrose easily produces bubbles when it enters the gastric juice, which affects the imaging effect. In addition, the product of this invention has no therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0054] The preparation method of the tablet of the present invention comprises: 1000g of Atractylodes macrocephala, 1000g of poria cocos, 1000g of turmeric, 1000g of tangerine peel, 1000g of magnolia officinalis, 1000g of woody fragrance, 1000g of atractylodes rhizome, 1000g of sea octopus, 1000g of calcined oyster, 1000g of yam, 1000g of Jiao Sanxian, nutmeg 1000g, gallinaceous gold 1000g, Cyperus cyperi 1000g, Codonopsis 1000g, black medicine 1000g, Eclipta 1000g, Gardenia 1000g, Scutellaria baicalensis 1000g, Patrinia 1000g;

[0055] First crush the above-mentioned raw materials into coarse powder, put them into a multi-functional extraction tank for extraction twice, add 8-10 times the amount of water to decoct for 1-2 hours for the first time, and add 4-8 times the amount of water to decoct for 1-2 hours for the second time For 2 hours, combine the two decoctions, filter to obtain the filtrate; heat and concentrate to a paste, add 10-20 g of calcium gluconate and 10-20 g o...

experiment example 2

[0070] Experimental example 2: the long-term toxicity test of medicine of the present invention to rat: get rat and select two dosage groups for use, be respectively 75g / kg and 22.5g / kg (equivalent to 45 times and 13.5 times of adult's clinical dosage), select simultaneously Distilled water was used as blank control group. According to the relevant regulations in the "Guidelines for the Preclinical Research of New Chinese Medicines", the rats were gavaged with the highest concentration and the largest gavage volume, 7 days a week, for 4 consecutive weeks, and after feeding under the same conditions, the rats grew The animal is in good condition, can move freely, has a shiny coat, eats and urinates normally, and gains weight naturally. No obvious toxic reaction was found, and no animal died. The blood routine and blood biochemical indexes of the rats were all in the normal range, and no obvious toxic damage was found in the pathological examination of important organs.

experiment example 3

[0071] Experimental example 3: Cumulative toxicity test:

[0072] The traditional Chinese medicine contrast agent oral administration powder of the present invention is used continuously for 15 weeks by 7.69, 19.18 and 43.21g crude drug / kg (1.0ml / 100g body weight, 2 times a day) and after 3 weeks of drug withdrawal, the results show that: the traditional Chinese medicine aid of the present invention The contrast agent had no obvious effect on the hair, behavior, defecation, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators of the rats. No abnormal changes were found in the organs and histological examination results showed that the drug After 15 weeks and 3 weeks after stopping the drug, there was no obvious change in the organs of the rats. It shows that the traditional Chinese medicine imaging aid powder of the present invention has little toxicity to rats after long-term administration, and there is no abnorma...

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Abstract

The invention provides a traditional Chinese medicine contrast medium adjuvant used for B ultrasonic, which comprises the following materials in part by weight: 10-20 parts of bighead atractylodes rhizome, 10-20 parts of poria cocos, 10-20 parts of turmeric, 10-20 parts of tangerine peel, 10-20 parts of cortex magnoliae officinalis, 10-20 parts of radix aucklandiae, 10-20 parts of Rhizoma atractylodis, 10-20 parts of cuttlebone, 10-20 parts of calcined oyster shell, 10-20 parts of Chinese yam, 10-20 parts of charred triplet, 10-20 parts of myristica fragrans, 10-20 parts of gizzard pepsin, 10-20 parts of rhizome cyperi, 10-20 parts of codonopsis pilosula, 10-20 parts of combined spicebush root, 10-20 parts of eclipta, 10-20 parts of jasmine, 10-20 parts of baical skullcap root and 10-20 parts of field pennycress. The traditional Chinese medicine contrast medium adjuvant used for B ultrasonic provided by the invention not only can adapt to stomach hyperfunction type, but also can adapt to decreased stomach function type, and also can be applied to the mixed type of various flatulence and mucinosis, check time is short, imaging rate is high, and preparation process is simple and practical. The contrast medium adjuvant has no obvious toxic side effect and has prospect on further development research.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine image aid for B-ultrasound and a preparation method thereof. Background technique [0002] Ultrasound image diagnosis is one of the important diagnostic methods in medicine. Ultrasound has three major effects on matter: one is mechanical action, because the ultrasonic energy is huge, it often makes the material particles vibrate at high frequency mechanically, thus producing crushing, agglomeration, and stirring effects. The second is the thermal effect. When the ultrasonic wave acts on the substance, its energy is absorbed by the substance, thus increasing the temperature of the substance. The third is cavitation. When the ultrasonic wave acts on the liquid, the area with weak internal stress in the liquid (such as microscopic bubbles, etc.) becomes sparse due to the huge change in the sound pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K36/9066A61P1/14A61K35/37A61K35/56A61K35/57A61K35/618
Inventor 张洪英安玉胜
Owner 张洪英
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