60results about How to "Increase body weight" patented technology

This invention relates to compounds of the formula

wherein one of R⁵, R⁶ and R⁷ is

and X¹, X², Y¹ to Y⁴, R¹ to R¹³ and m and n are defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.

The present invention provides a method of modulating appetite and/or body weight in a subject, said method comprising administering to said subject an effective amount of a MIC-1 modulating agent, wherein said agent increases or decreases the amount of MIC-1 present in said subject, or inhibits or enhances the biological activity of present in said subject.

Disclosed is a novel food product characterized by a low glucose or glucose free content, a balanced functional fat content, and a proactive agent aimed for the diabetic and diabetic-prone populations. The food product of the invention is a functional food which may be used clinically to lower the lipid level in people suffering from an imbalanced lipid profile and which may progress towards diabetes complications and coronary vascular disorders. In particular embodiments the proactive agent can be any of a naturally occurring lipid, a synthetic or mimetic lipid which is not digestible by humans and interferes with body weight gain/loss, plant extracts and substances derived therefrom, antioxidants, animal-derived substances, minerals and pharmaceuticals, and any mixture thereof.

Compounds of Formula 1 or pharmaceutically acceptable salts thereof are provided:

which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

Compounds of formula I or pharmaceutically acceptable salts thereof are provided:

wherein each of R¹, R^1′, R², R³, R⁴, n, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

Compounds of formula 2 or pharmaceutically acceptable salts thereof are provided:

wherein each of R^1a, R^2a, R^3a, Ar, y, and m are as defined herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, are used to treat a variety of central nervous system disorders such as schizophrenia.

The present invention relates to methods and compositions for the treatment of body weight disorders, including, but not limited to, obesity. Specifically, the present invention identifies and describes genes which are differentially expressed in body weight disorder states, relative to their expression in normal, or non-body weight disorder states, and/or in response to manipulations relevant to appetite and/or weight regulation. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in body weight disorders and/or appetite and/or body weight regulation. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of body weight disorders. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various body weight disorders, and for the identification of subjects exhibiting a predisposition to such conditions.

Adiponectin cDNA was cloned into AAV serotypes 1, 2, and 5-based expression vectors. Virions containing these vectors were administered to the livers of rat subjects via portal vein injection. A single injection of 6×10¹¹ virions of the vector caused a sustained and statistically significant reduction in body weight of the treated animals compared to the control animals. This occurred in the absence of side effects. Compared to control animals, the subject rats also exhibited reduced adipose tissue mass, reduced appetite, improved insulin sensitivity, and improved glucose tolerance.

Disclosed are modulators, i.e., activators and inhibitors, of Intestinal Alkaline Phosphatase (IAP). Also disclosed are methods for treating bacterial infections of the intestinal tract and methods for maintaining the health of the intestinal tract using IAP activators. Further disclosed are methods to assist in weight gain of emaciated patients and those having reduced or negligible fat absorption using IAP inhibitors.

The present invention disclosed a liquid acidifier and making method. The present invention comprises organic acids and relevant soluble salts. After the organic acids and the relevant soluble salts are treated by the following procedures of heating, melting, mixing, removing bacteria, filtrating and so on, the liquid acidifier is made. The content of organic acids is over 70percent, which can reduce the pH value of drinking water and intestine, can prevent the harmful flora, can restrain the growth of the salmonella, at the same time can improve the stress ability of the animals, can reduce the death rate and promote the growth rate, and can enhance the absorption rate and conversion of feed. The present invention provides a new idea for developing a compound acidifier.

The invention discloses an organic acid acidifying agent, which comprises the following components in part by weight: 40 to 70 parts of formic acid, 5 to 20 parts of acetic acid, 10 to 60 parts of formate, and 1 to 5 parts of carbonate. The liquid acidifying agent is safe to use, and has no any toxic and side effect on the growth of animals; secondly, the liquid acidifying agent has higher buffer capacity, avoids overlarge fluctuation of gastrointestinal acidity of the animals, and can keep a stable digestion environment in the stomach and intestine for long time through mutual transformation of organic acid and organic acid salt; moreover, the combination of the liquid acidifying agent and the organic acid can effectively reduce the pH values of drinking water and the intestines, and inhibit the growth of harmful colonies; and meanwhile, the liquid acidifying agent can also effectively improve the stress capability of the animals, reduce the death rate, promote the growth, improve the digestive absorption effect of fodder, reduce the fodder-meat ratio, and improve the daily gain.

This invention relates to compounds of the formula

wherein one of R⁶, R⁷ and R⁸ is

and X, Y¹ to Y⁴, R¹ to R¹⁴ and n are as defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.

The invention discloses a cultivation method capable of improving the quality of long-section bamboo shoots. The cultivation method mainly comprises the steps of bamboo forest selection, stand structure regulation, earth covering, forest land reclamation, fertilization, bamboo shoot harvesting and ecological pest control and prevention. In the step of earth covering, a long-section bamboo forest land is uniformly coated by yellow earth or red earth which is not cultivated from September to February in the next year, and stones and stalks in the yellow earth or the red earth which is not cultivated are removed, wherein the content of soil clay is 50-70 percent, the volume weight of the soil clay is about 1.2, the pH value is 4.5-5.5, and the earth covering thickness is 25-35cm. According to the technology, the high-quality bamboo shoot operation of long-section bamboos for 3-5 years can be maintained by virtue of one-time earth coating, the bamboo shoot formation period can be prolonged for about 15 days, the quality of the bamboo shoots is improved, and the economic value is increased.

The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

The present invention relates to compositions and methods for the use of T cells and more particularly, activated T cells, in the treatment and/or amelioration of diseases associated with a proinflammatory state, such as cachexia, chronic diseases such as chronic renal failure, and hepatitis.

Compounds of formula 1 or pharmaceutically acceptable salts thereof are provided:

which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

Alkyne compounds of formula I

wherein A, B, W, X, Y, Z, R¹, and R² have the meanings given herein, which have MCH-receptor antagonistic activity and are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.

Animal nutrition compositions include a carrier and a fermentation product applied to the carrier. Liquid fermentation products are fluidly applied to dry carriers, such as phyllosilicates or other earthen components, while mixing and applying air flow, under appropriate temperature and pH conditions, to bind the fermentation product to the carrier and dry the reaction product to appropriate moisture content. Fermentation products are also mixed with liquid carriers, such as water. Fermentation products include components of a microbial fermentation culture, such as liquid medium, microbial cellular components, and fermentation metabolites produced by microorganisms. Some compositions include a pH buffering agent and/or additional components to further enhance beneficial effects of the composition, such as improved weight gain and feed conversion, reduced gut lesions, harmful gut bacteria count, and decreased mortality. Compositions can be mixed with animal feeds or otherwise administered. Compositions can inhibit fungal growth on animal feeds.

Anti-obesity material of the present invention is absorbed in vivo by oral ingestion, drops, etc. so as to act against the causes of overeating and control food consumption, and it can thereby promote fat metabolism and control accumulation of body fat while at the same time can inhibit elevation of blood pressure, all without compromising immune system function, thus safely controlling an increase in body weight (obesity). There have previously been no anti-obesity materials like that of the present invention whatsoever. The main characteristic of the present invention is that an anti-obesity material having the above-described excellent effects is obtained since the anti-obesity material has isoflavone aglycone and/or isoflavone glycoside.

Compositions and methods for treating diseases or disorders associated with the metabolic syndrome using conjugates of bile acids with basic amino acids or a decarboxylated amino acid such as agmatine are provided. Further provided are bile acid-basic amino acid conjugates including chenodeoxycholic acid with an amino acid selected from arginine, lysine, histidine, ornithine or a decarboxylated amino acid such as agmatine.

The invention relates to bamboo vinegar added into a fryer forage and application thereof. The recommended addition amount of the bamboo vinegar is 1%, and the bamboo vinegar is characterized by comprising, by weight, about 80%-90% of water, 0.32% of acetic acid, 0.023% of methanol, 0.02% of propionic acid, 0.015-0.028% of amino acids, 0.0064% of a phenol, 0.0040% of o-cresol, 0.0022% of a furfural, and 0.5-1% of other materials. A fryer forage added with the bamboo vinegar for compatibility provides the following nutrient levels: the metabolic energy is 12.56 MJ/kg and crude protein accounts for 21.88% when the fryer forage is provided at 0-3rd week, and the metabolic energy is 13.34 MJ/kg and crude protein accounts for 19.41% when the fryer forage is provided at 3rd-6th week. The bamboo vinegar is capable of improving the production performance of a fryer as well as reducing ammonia gas generated in fermented chicken manure, and improving breeding environment.

The present invention discloses an anti-obesity agent comprising:

• • D-cysteinolic acid represented by Formula I, as an active ingredient:
  • Formula I:

The present invention provides feed compositions comprising a basal animal diet supplemented with direct fed microbial (DFM) and at least one of a formulated yeast, a capsicum product, and an antimicrobial clay. The feed compositions improve growth, general health, intestinal health, and reduce microbial pathogens in non-human animals fed the feed compositions.

The disclosure features a human milk cream composition, standardized high fat human milk formulations as well as methods of making and using such compositions. In particular, the disclosure features a method of using a human milk cream composition and/or standardized high fat human milk formulations to treat infants with bronchopulmonary dysplasia (BPD) or at risk of developing BPD.

The invention discloses an anti-stress traditional Chinese medicine feed additive as well as a preparation method and an application thereof. The anti-stress traditional Chinese medicine feed additive mainly comprises the following medicinal components: codonopsis pilosula, seeds of wild jujube, poria cocos, magnolia officinalis, ash bark, pseudo-ginseng, hawthorn, herba andrographitis, coptis chinensis, radix paeoniae rubra, prepared rehmannia root, rheum officinale and liquorice. The raw materials are dried, crushed, screened and uniformly mixed by adopting a traditional Chinese medicine production device, the prepared traditional Chinese medicinal preparation is added into basic daily ration of 60-day-old health little meishan sow to be uniformly mixed so as to feed the sow, and the freedom foraging and drinking are implemented. The test proves that the anti-stress traditional Chinese medicine feed additive can remarkably improve the total protein and albumin concentration in porcine serum; the content of immune globulin IgG and the content of complement C3 in the porcine serum can be remarkably increased; the antibody level of the immunized swine fever is obviously increased; the pig spleen index is increased. Various weaknesses of various chemical drugs and antibiotic feed additives can be overcome, no toxicity and side effect and no chemical residue exist, and the production of environment-friendly and high-quality animal product is guaranteed while the immunity of the body is improved.

Methods for treating eating disorders associated with excessive weight gain, suppressing appetite, reducing body weight, or treating obesity in an animal by administering one or more antagonists of the serotonin Htr1a or Htr2b receptor, or a Tph2 inhibitor are provided, or combinations thereof.

Disclosed is a composition comprising: a. Cynara extract having a caffeoylquinic acid content ranging from 30 to 45% by weight, a flavonoid content ranging from 8 to 16% by weight and a cynaropicrin content ranging from 10 to 18% by weight; b. Coffea spp. extract containing between 40% and 80% by weight of caffeoylquinic acids; c. Olea europaea extract containing between 30% and 40% polyphenols, with a verbascoside content exceeding 5% and a hydroxytyrosol content exceeding 1.5%.

The invention discloses application of high-light-intensity lamps in silkworm breeding and a scheme for breeding silkworms by utilizing natural light in a silkworm room in cooperation with yellow LED lamps. Specifically, the silkworms are bred in the silkworm room which the natural light can enter, and the yellow LED lamps with the illumination intensity ranging from 10 Lux to 150 Lux are installed in the silkworm room; in the daytime, the natural light permeating into the silkworm room is supplanted to the silkworms in the silkworm room, and at night, namely, after 18:00-19:00, the yellow LED lamps are turned on and are kept on for 12-14 h with the average illumination intensity making contact with the surfaces of silkworm bodies ranging from 10 Lux to 150 Lux. By means of the breeding scheme, the growing speed of the silkworms can be increased, the life cycle can be shortened, the weight gain of the silkworm bodies can be increased, the mounting time of matured silkworms can be shortened, the cocoon shell rate of silkworm cocoons can be increased, and the disease resistance of the domestic silkworms can be enhanced. In addition, the scheme saves labor and energy and is safe, reliable, low in maintenance cost and especially suitable for producing commercial young silkworms, cooperatively breeding young silkworms and breeding silkworms by silkworm breeders.