The invention relates to a method for simultaneously producing honeysuckle flower distillate and various active substances. The invention relates to a method for simultaneously producing various physiologically active substances such as honeysuckle flower distillate, honeysuckle flower polysaccharide and chlorogenic acid by using honeysuckle flowers as a raw material. The method comprises the steps of vacuum distillation, precipitation separation, macroporous resin separation, and silica gel column separation. The method has the advantages of reasonable design, simple method, and easy popularization. In prior arts, a large amount of organic solvents are adopted for extracting and preparing chlorogenic acid, such that environment pollution is caused; also, the purity is not high, production cost is high, and production efficiency is low. With the method, the problems are solved, and various by-products obtained during honeysuckle flower distillate production process can be comprehensively utilized. Therefore, various physiologically active substances such as honeysuckle flower polysaccharide, high-purity chlorogenic acid, 2-caffeoylquinic acid, 3,4-caffeoylquinic acid and the like are obtained. Therefore, production cost is saved, production efficiency is improved, the process is simple, and the process can easily be applied in industrialized productions. Therefore, raw material utilization rate can be greatly improved.