Elephantopus scaber extract as well as preparation method and applications thereof in preparing antiviral drugs

The technology of an extract and C. chinensis, which is applied in the field of preparation of antiviral drugs, can solve the problems of toxic side effects, drug resistance, difficulty, virus antigen variability, antiviral drug resistance, antiviral drug resistance, and antiviral drug research and development difficulties. To achieve the effect of low cytotoxicity

Inactive Publication Date: 2013-09-04
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since viruses are intracellular parasitic microorganisms, their replication is closely related to many biochemical processes of host cells. Therefore, it is difficult to find antiviral drugs that can selectively inhibit viruses without affecting the functions of host cells; Factors such as variability and resistance to antiviral drugs also cause difficulties in the research and development of antiviral drugs
Therefore, there are far fewer antiviral drugs approved by the FDA for clinical use than antibacterial drugs, and there are still problems such as toxic side effects and drug resistance.

Method used

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  • Elephantopus scaber extract as well as preparation method and applications thereof in preparing antiviral drugs
  • Elephantopus scaber extract as well as preparation method and applications thereof in preparing antiviral drugs
  • Elephantopus scaber extract as well as preparation method and applications thereof in preparing antiviral drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Get the dry root 200g of the herbal medicine Didancao of Compositae (collected from Guangdong, identified by Mai Zhenqiu, senior engineer of Guangzhou Medicinal Materials Company), pulverize, and use 2000mL of 95% ethanol aqueous solution to reflux extract 2 Once, each time for 1 hour, filter, combine the filtrates, concentrate under reduced pressure until there is no alcohol smell, and obtain the crude extract extract;

[0026] Weigh 500g of macroporous adsorption resin (D101), add 800mL of distilled water, stir evenly, remove the resin monomer or fragments by water flotation, and then place it at room temperature for 24 hours. After the resin is fully swollen, drain the resin, and then use ethanol Pack the column by wet method, wash the column with ethanol flow until the volume ratio of the effluent and water is 1:5 and the mixture does not become white turbidity, then fully rinse the column with distilled water until the effluent has no smell of ethanol, and place the...

Embodiment 2

[0029] Grind the dry root of 200g of Radix Echinacea, reflux extraction with 2000mL of distilled water for 3 hours, filter, concentrate the filtrate with a rotary evaporator, add an ethanol solution with a mass percentage concentration of 95% under stirring until the ethanol content is a mass percentage concentration of 80%, Stand still for 24 hours, filter the supernatant, recover ethanol under reduced pressure until there is no alcohol smell, and obtain the crude extract extract. The extract of the crude extract was purified by a macroporous adsorption resin column to obtain the extract 2 of Echinopsis chinensis, and the purification method was consistent with that of Example 1. Calculated by the weight of the dry product of the extract, the mass percent content of the total phenols in the G. chinensis extract is greater than 50%.

Embodiment 3

[0031] Grind 200g of the dried roots of Echinopsis chinensis, reflux three times with 2000mL of distilled water, each time for 1-3 hours, filter, and combine the filtrates to obtain the crude extract. The extract of the crude extract was purified by a macroporous adsorption resin column to obtain the extract 3 of Echinopsis chinensis, and the purification method was consistent with that of Example 1. Calculated by the weight of the dry product of the extract, the mass percent content of the total phenols in the G. chinensis extract is greater than 50%.

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Abstract

The invention discloses an elephantopus scaber extract as well as preparation method and applications thereof. The preparation method for the elephantopus scaber extract comprises the steps of extracting entirely-dried elephantopus scaber or roots with ethanol or water, and then purifying through macroporous absorption resin columns to obtain the extract, wherein activate ingredients are caffeoylquinic acid substances. In the invention, the elephantopus scaber extract with anti-respiratory virus effect is extracted and enriched from herb-elephantopus scaber widely applied in civil society at Guangdong Province, China for the first time, and can be used for preparing drugs or health-care products for preventing respiratory syncytial virus, parainfluenza 3-type virus or influenza A virus. The invention not only provides a certain scientific proof for civil application of the elephantopus scaber, but also provides new resources for developing novel and safety and efficient anti-respiratory virus drugs.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to an extract obtained from the traditional Chinese medicine Elephantopus scaber, a preparation method thereof and an application in preparation of antiviral drugs. Background technique [0002] Elephantopus scaber (Elephantopus scaber) is a plant of the genus Elephantopus in the family Compositae, also known as the head of the gallbladder, the gallbladder, and the scaber. It is mainly distributed in South China and Southwest China. , the efficacy of dampness, the herb is widely used in folk in Guangdong, my country, for the treatment of colds, whooping cough, jaundice, pharyngitis, conjunctivitis, nephritis, eczema and insect bites, etc., and included in the 1977 edition of "Chinese Pharmacopoeia". The main chemical constituents in G. chinensis are sesquiterpenoids, flavonoids and caffeoylquinic acid compounds. Modern pharmacological studies have shown that Glycyrrhizae...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C69/732C07C69/757C07C67/56A61K31/216A61P31/14A61P31/16A23L1/29A23L33/00
Inventor 李药兰叶文才吴霞王国才王英张晓琦张冬梅
Owner JINAN UNIVERSITY
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