Extract of plant in blumea genus as well as preparation method and application thereof

The technology of Ainacia and its extract is applied in the field of Ainacia plant extract and its preparation, and achieves the effects of strong pharmacological action, reducing the content of virus and relieving pulmonary inflammation.

Active Publication Date: 2015-05-27
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The parts of total caffeoylquinic acid in Diangui Ainaxiang and its prevention and treatment of respiratory virus infection have not been reported

Method used

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  • Extract of plant in blumea genus as well as preparation method and application thereof
  • Extract of plant in blumea genus as well as preparation method and application thereof
  • Extract of plant in blumea genus as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 The preparation of the extract of Ai Naxiang from Yunnan Gui

[0037] Dry 1000g of whole grass powder of Blumea riparia (produced in Baise, Guangxi), reflux extraction with 5000ml of 70% ethanol for 3 times, each time for 2 hours, combine the extracts, recover under reduced pressure until alcohol-free taste, to obtain a concentrated solution, the obtained concentrated solution is extracted 3 times with 500ml of n-butanol, combined 3 times of n-butanol extracts, and recovered under reduced pressure to obtain 13.0g dry extract, which is the extraction of osmanthus osmanthus Ainaxiang of the present invention. things. After determination, the mass content of the total caffeoylquinic acid is 82%.

Embodiment 2

[0038] Example 2 Preparation of Yunnan Gui Ai Na Xiang Extract

[0039] Dry 1000g of Yunnan Gui Ainaxiang (Blumea riparia) (produced in Baise, Guangxi) coarse powder, reflux extraction with 5000ml of 50% ethanol for 3 times, each time for 2 hours, combine the extracts, recover under reduced pressure until there is no alcohol smell, Obtain a concentrated solution, extract the obtained concentrated solution with 500ml of n-butanol for 3 times, combine the 3 times of n-butanol extracts, recover under reduced pressure to obtain 16.0g of dry extract, that is, the extract of Ayina osmanthus of the present invention. After determination, the mass content of the total caffeoylquinic acid is 67%.

Embodiment 3

[0040] Example 3 Preparation of Yunnan Gui Ainaxiang Extract

[0041] Dry 1000 g of dried osmanthus osmanthus (Blumea riparia) (produced in Baise, Guangxi) coarse powder, reflux extraction with 5000 ml of 95% ethanol for 3 times, each time for 2 hours, combine the extracts, recover under reduced pressure until there is no alcohol smell, Obtain the concentrated solution, extract the obtained concentrated solution with 500ml of n-butanol for 3 times, combine the 3 times of n-butanol extracts, recover under reduced pressure to obtain 22.0g of dry extract, that is, the extract of the present invention. After determination, the mass content of the total caffeoylquinic acid is 55%.

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Abstract

The invention belongs to the technical field of natural herbal medicines and particularly relates to an extract of a plant in blumea as well as a preparation method and application thereof. The extract contains 10-99wt% of total caffeoylquinic acid. The preparation method of the extract comprises the following steps: (S1) pulverizing the plant in blumea wholly or partially, and extracting with an organic solvent, water or the solution of the organic solvent in water to obtain a crude extract; and (S2) extracting the crude extract with n-butanol or purifying with a macroporous adsorption resin column to obtain the extract of the plant in blumea. The extract provided by the invention has a good antiviral effect, can be used for preparing medicines for preventing and treating virus infection and health care products, is definite in effective components, low in toxicity and strong in pharmacologic action and has good application prospect. In addition, the preparation process of the extract is simple and is suitable for large-scale production.

Description

technical field [0001] The invention belongs to the field of plant natural medicines, and in particular relates to a plant extract of the genus Aynaxa and its preparation method and application. Background technique [0002] Respiratory virus infection is one of the infectious diseases that seriously endanger human health, among which respiratory syncytial virus, influenza virus and parainfluenza virus are the main pathogens of respiratory virus infection. Respiratory syncytial virus (respiratory syncytium virus, RSV) belongs to the paramyxoviridae pneumovirus genus, and the respiratory infection, laryngitis, tracheitis, bronchitis and pneumonia it causes are common and frequently-occurring diseases in clinical practice, and are susceptible to The crowd is children and old people. RSV infection can pose a serious threat to the life of infants, premature infants, and children with chronic lung disease, congenital heart disease, and immunosuppression. Serological statistics ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A23L1/29A61P31/14A61P31/16A61P11/00A23L33/00
Inventor 叶文才李药兰张晓琦范春林王国才李满妹王英王磊
Owner JINAN UNIVERSITY
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