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Traditional Chinese medicine composition content determination method

A determination method and composition technology, which are used in pharmaceutical formulations, active ingredients of hydroxyl compounds, measuring devices, etc.

Active Publication Date: 2017-09-12
SHIJIAZHUANG YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the content determination method is mainly based on a single component, and there is rarely a method for simultaneously determining multiple active components.
[0003] The present invention claims to protect a content determination method of a traditional Chinese medicine composition, which is composed of the following medicinal materials: forsythia, honeysuckle, isatis root, bitter almond, menthol, houttuynia cordata, rhubarb, patchouli, Mianmaguanzhong , Rhodiola rosea, ephedra, licorice, gypsum, this content determination method simultaneously determines neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isoforsythiaside A, 4,5-di-O-caffeoylquinone The content of the seven components of nitric acid, quercitrin and glycyrrhizinic acid can effectively save energy and reduce analysis costs, but the technical content is not disclosed in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0159] Weighing in proportion: Forsythia 200g, honeysuckle 300g, Radix Radix 200g, Rhubarb 40g, Patchouli 60g, Mianma Guanzhong 300g, Rhodiola rosea 100g, Menthol 9g, Ephedra 60g, Bitter almond 100g, Houttuynia cordata 200g, Licorice 100g, gypsum 200g, extract according to the following process:

[0160] (1) Weigh the Chinese herbal medicine according to the weight ratio of the raw material drug, select it cleanly, and break it as appropriate;

[0161] (2) Patchouli is broken, add 10 times the amount of water to extract the volatile oil, the oil extraction time is 8 hours, collect the volatile oil, and set aside; after the extract is filtered, the residue is discarded, and the filtrate is set aside;

[0162] (3) Forsythia, ephedra, houttuynia cordata, rhubarb, extract 3 times with 12 times the amount of 70% ethanol, each time for 2.5 hours, the extracts are combined and filtered, the ethanol is recovered, and the filtrate is used for later use;

[0163] (4) Honeysuckle, gypsu...

Embodiment 2

[0176]Weighing in proportion: Forsythia 300g, honeysuckle 200g, Radix Radix 300g, Rhubarb 60g, Patchouli 100g, Mianma Guanzhong 200g, Rhodiola rosea 60g, Menthol 5g, Ephedra 100g, Bitter almond 60g, Houttuynia cordata 300g, Licorice 60g, gypsum 300g, extract according to the following process:

[0177] (1) Weigh the Chinese herbal medicine according to the weight ratio of the raw material drug, select it cleanly, and break it as appropriate;

[0178] (2) Patchouli is broken, add 10 times the amount of water to extract the volatile oil, the oil extraction time is 8 hours, collect the volatile oil, and set aside; after the extract is filtered, the residue is discarded, and the filtrate is set aside;

[0179] (3) Forsythia, ephedra, houttuynia cordata, rhubarb, extract 3 times with 12 times the amount of 70% ethanol, each time for 2.5 hours, the extracts are combined and filtered, the ethanol is recovered, and the filtrate is used for later use;

[0180] (4) Honeysuckle, gypsum,...

Embodiment 3

[0193] The formula of the raw material medicine is: 278g forsythia, 294g honeysuckle, 285g isatidis, 55g rhubarb, 95g patchouli, 290g Mianmaguanzhong, 87g rhodiola, 8.5g menthol, 88g ephedra, 80g bitter almond, 284g Houttuynia cordata , licorice 95g, gypsum 277g, extracted according to the following process:

[0194] (1) Weigh the Chinese herbal medicine according to the weight ratio of the raw material drug, select it cleanly, and break it as appropriate;

[0195] (2) Patchouli is broken, add 10 times the amount of water to extract the volatile oil, the oil extraction time is 8 hours, collect the volatile oil, and set aside; after the extract is filtered, the residue is discarded, and the filtrate is set aside;

[0196] (3) Forsythia, ephedra, houttuynia cordata, rhubarb, extract 3 times with 12 times the amount of 70% ethanol, each time for 2.5 hours, the extracts are combined and filtered, the ethanol is recovered, and the filtrate is used for later use;

[0197] (4) Honey...

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Abstract

The present invention relates to a traditional Chinese medicine composition content determination method, wherein the traditional Chinese medicine composition comprises the following herbs such as forsythia suspensa, honeysuckle, radix isatidis, bitter almond, menthol, herba houttuyniae, rheum palmatum l, pogostemon cablin, dryopteris crassirhizoma, rhodiola rosea l, ephedra sinica stapf, licorice root and gypsum. According to the present invention, with the content determination method, the contents of seven components such as neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isoforsythiaside A, 4,5-di-O-caffeoylquinic acid, quercitrin and glycyrrhizic acid are simultaneously determined, such that the energy source can be effectively saved, and the analysis cost can be reduced, wherein the traditional Chinese medicine composition content determination method of the present invention is not disclosed in the prior art.

Description

technical field [0001] The invention relates to a content determination method of a traditional Chinese medicine composition, belonging to the field of medicine quality control methods. Background technique [0002] Traditional Chinese medicine is the most important material means of preventing and treating diseases in traditional Chinese medicine. The modernization of traditional Chinese medicine carried out in my country since the "Ninth Five-Year Plan" is a major measure to promote the development of the traditional Chinese medicine industry. The quality control and evaluation of traditional Chinese medicine is one of the key issues in the modernization of traditional Chinese medicine, and it is also a difficult point and a hot spot in the research of traditional Chinese medicine. The purpose of quality control of traditional Chinese medicine is to ensure the effectiveness and safety of traditional Chinese medicine. The quality control of traditional Chinese medicine is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78G01N30/02A61K33/06A61K31/045
CPCA61K31/045A61K33/06A61K36/11A61K36/17A61K36/195A61K36/315A61K36/355A61K36/41A61K36/484A61K36/53A61K36/634A61K36/708A61K36/736A61K36/78A61K2236/331A61K2236/333A61K2236/39A61K2236/51G01N30/02A61K2300/00A61K36/35G01N30/88
Inventor 陈育鹏毕丹赵倩张水英叶玉廷任晋魏峰
Owner SHIJIAZHUANG YILING PHARMA
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