42 results about "Ainsliaea fragrans" patented technology

The invention relates to ainsliaea fragrans champ caffeoylquinic acid extracts and preparation and application thereof. The ainsliaea fragrans champ caffeoylquinic acid extracts are prepared by the following steps of: performing refluxing extraction of the ainsliaea fragrans champ by using ethanol, filtering, concentrating and removing ethanol, adjusting the pH value to 1 to 3 by adding hydrochloric acid, applying macroporous adsorbent resin, water-washing, adding ethanol for gradient elution, and collecting eluent, of which the ethanol concentration is 50 to 70 percent; performing condensation and ethanol removal, adjusting the pH value to 1 to 3 by adding hydrochloric acid, using macroporous adsorbent resin, adding water and ethanol for gradient elution respectively, and collecting the eluent, of which the ethanol concentration is 40 to 70 percent; mixing the eluent, and vacuum drying the eluent to obtain the extracts. The UV content of the ainsliaea fragrans champ caffeoylquinic acid extracts is over 70 percent, the HPLC content is over 50 percent, and the content of 3-caffeoylquinic acid and the content of 3,5-dicaffeoylquinic acid are both over 10 percent. The ainsliaea fragrans champ caffeoylquinic acid extracts have the effects of resisting inflammations, bacteria, medicament-resistant strains, well improves pathologically changed tissues of rat suffering from cervicitis, obviously reduces the uterus index and the number of leukocytes and can be independently prepared into the medicaments for treating cervicitis or combined with other medicaments to prepare the medicaments for treating cervicitis.

The present invention discloses a kind of glabrous ainsliaea herb extract, which is extracted with glabrous ainsliaea herb, and through crushing, decocting in distilled water, filtering, concentrating filtrate, regulating pH with hydrochloric acid, centrifuging, adsorbing the supernatant in macroporous resin, eluting with ethanol, merging with acid precipitate and drying. The present invention also discloses the application of the glabrous ainsliaea herb extract in preparing medicine for treating acute and chronic cervicitis.

The present invention relates to a Frangrant Ainsliaea Herb extract and active components, as well as the quality control method. The Frangrant Ainsliaea Herb extract contains sesquiterpene lactones in formula (1) and chlorogenic acids in formula (2). In formula (1), R1 is hydrogen or glucosyl group, R2 is hydrogen or hydroxyl and R3 is methane or methyl; R1, R2 and R3 can be freely combined in the respective selective group categories. In formula (2), R1, R2 and R3 can be coffeoyl or hydrogen. The above two components can be applied in the quality control of Frangrant Ainsliaea Herb medicinal material or the extract.

The invention relates to the technical field of Chinese pharmaceutical manufacturing, particularly to a method for extracting and further processing ainsliaea fragrans total flavonoid. With ainsliaea fragrans adopted as the raw medicinal material, the method comprises the following steps: firstly, smashing ainsliaea fragrans; carrying out ultrasonic immersion extraction on the smashed ainsliaea fragrans in ethanol water for a plurality of times; then, combining extracting solutions; decompressing and concentrating the extracting solutions; adding ethyl alcohol into the concentrated solution, and carrying out low-temperature standing for alcohol precipitation; filtering with a micropore filter membrane; decompressing and concentrating the filtrate; carrying out vacuum drying on the concentrated solution to obtain refined ainsliaea fragrans total flavonoid extract; finally, adding pharmaceutical excipients for further preparing the ainsliaea fragrans total flavonoid extract into various pharmaceutical preparations. According to the method, ultrasonic wave and continuous countercurrent extraction technologies are combined, so that the dissolution and spreading of the effective components are quickened, the extraction time is greatly shortened, the extraction efficiency is improved, the degradation of heat sensitive components is avoided, the energy consumption and production cost are further reduced, the extraction preparation technology is relatively simple and convenient, and the method is applicable to industrial large-scale production.

The invention provides a quality control method for an extraction process of Chinese medicine ainsliaea fragrans champ, and the quality control method comprises the following steps: firstly, measuring the content of chlorogenic acid in a qualified ainsliaea fragrans champ extract solution and acquiring a near-infrared spectrum; secondly, respectively establishing a corresponding model between thenear-infrared spectrum and the content of the chlorogenic acid in the ainsliaea fragrans champ extract solution by adopting chemometric software; thirdly, measuring the near-infrared spectrum of a chlorogenic acid sample of which the content is to be measured; and fourthly, by using the corresponding model, respectively acquiring the content of the chlorogenic acid in the chlorogenic acid sample of which the content is to be measured through the chemometric software.

The invention belongs to the pharmaceutical technology field and provides an extract of total flavonoids of frangrant ainsliaea herb, an extraction method thereof and a use. The extract adopts the frangrant ainsliaea herb as a raw material, ethanol which is prepared by weak alkaline solutions with the different pH values is taken as an extraction solvent, the reflux extraction is adopted, the impurities are removed by the petroleum ether extraction, the separation and the enrichment are finally carried by macroporous resin, and the purity of the components of the obtained total flavonoids is 50-95 percent. The invention has simple process, convenient and safe operation and good repeatability and can be used for the industrial production. The invention further provides an application of the components of the total flavonoids or a preparation which is prepared by the total flavonoids and a pharmaceutically acceptable carrier in the prepration of drugs for treating acute and chronic cervicitis.

The invention belongs to the technical field of traditional Chinese medicine extraction, and particularly to an ainsliaea fragrans champ extract, an extraction method and an application thereof. The ainsliaea fragrans champ extract is an ethyl acetate extract or / and a methanol extract of ainsliaea fragrans champ, and is prepared by using the following method: crushing the whole grass of ainsliaea fragrans champ, adding ethyl acetate, carrying out heating reflux extraction 2-3 times, filtering, respectively mixing the filter residues and the filtrates obtained from the two extractions, carrying out concentration drying on the filtrate to obtain the ethyl acetate extract, carrying out heating reflux extraction 2-3 times on the filter residue with methanol, filtering, mixing the filtrates obtained from the two extractions, carrying out concentration drying on the filtrate to obtain the methanol extract. The ainsliaea fragrans champ extract has anti-oxidation activity and liver protection activity.

The invention belongs to the field of a medicament, in particular relating to a new application of a fragrant ainsliaea herb extractive. The new application is the purpose of the fragrant ainsliaea herb extractive in preparing a medicament for treating pharyngitis. The fragrant ainsliaea herb extractive is a filtrate obtained by decocting fragrant ainsliaea herb in water, precipitating the decocted solution with alcohol and filtering. The extractive has a definite treating function on acute and chronic pharyngitis.

The invention relates to an emergency medicine for snake wounds. The medicine comprises the following components in parts by weight: 5-12 parts of Jacaranda flower root, 5-12 parts of Ainsliaea fragrans, 3-5 parts of radix angelicae, 5-10 parts of common andrographis Herb, 1-4 parts of Paris polyphylla, 5-10 parts of Circium japonicum root, and 7-12 parts of Chinese lobelia. The preparation method comprises the following steps of: 1) crushing Jacaranda flower root, Paris polyphylla and radix angelica and uniformly mixing to obtain fine powder; 2) adding water to Circium japonicum root, Ainsliaea fragrans, common andrographis Herb and Chinese lobelia, and decocting concentrating the filtrate to obtain clear paste; 3) adding Jacaranda flower root, Paris polyphylla and radix angelica fine powder into the clear paste filtrate and uniformly mixing; and 4) drying, crushing to obtain fine power to obtain the medicine. Through clinical use for many years, the medicine provided by the invention is an emergency and treatment medicine for snake wounds which has remarkable curative effect and no adverse effect, is convenient to take and store and low in cost. The medicine is used for treating various venomous snake bites and has the functions of clearing away heat, detoxifying, stopping bleeding, removing swelling and relieving pain.

The invention relates to ainsliaea fragrans champ caffeoylquinic acid extracts and preparation and application thereof. The ainsliaea fragrans champ caffeoylquinic acid extracts are prepared by the following steps of: performing refluxing extraction of the ainsliaea fragrans champ by using ethanol, filtering, concentrating and removing ethanol, adjusting the pH value to 1 to 3 by adding hydrochloric acid, applying macroporous adsorbent resin, water-washing, adding ethanol for gradient elution, and collecting eluent, of which the ethanol concentration is 50 to 70 percent; performing condensation and ethanol removal, adjusting the pH value to 1 to 3 by adding hydrochloric acid, using macroporous adsorbent resin, adding water and ethanol for gradient elution respectively, and collecting the eluent, of which the ethanol concentration is 40 to 70 percent; mixing the eluent, and vacuum drying the eluent to obtain the extracts. The UV content of the ainsliaea fragrans champ caffeoylquinic acid extracts is over 70 percent, the HPLC content is over 50 percent, and the content of 3-caffeoylquinic acid and the content of 3,5-dicaffeoylquinic acid are both over 10 percent. The ainsliaea fragrans champ caffeoylquinic acid extracts have the effects of resisting inflammations, bacteria, medicament-resistant strains, well improves pathologically changed tissues of rat suffering from cervicitis, obviously reduces the uterus index and the number of leukocytes and can be independently prepared into the medicaments for treating cervicitis or combined with other medicaments to prepare the medicaments for treating cervicitis.

The invention discloses an Ainsliaea fragrans Champ soft capsule and a preparation method thereof. The active ingredients of Ainsliaea fragrans Champ are fully extracted by a scientific process, and prepared into a soft capsule; and the soft capsule effectively prevents the volatility and decomposition of an active ingredient chlorogenic acid, and ensures the stability of curative effect of the medicament. The Ainsliaea fragrans Champ soft capsule has stable medicinal performance and dosage, and is suitable for large scale market promotion.

The ainsliaea fragrans dripping pill of the present invention includes ainsliaea fragrans extract in recipe amount and medicinal supplementary material. The medicinal supplementary material includes polyglycol, polyoxyethylene stearate ester, sodium stearate, glyceric acid, urea and poloxamer. Compared with other preparation form, the dripping pill of the present invention has the advantages of fast acting, high bioavailability, simple production process, etc.

The invention discloses injection for treating the mastitis of female minks and a preparation method of the injection. 1000ml of the injection comprises 20g of mannitol, 60g of sodium chloride and 80g of traditional Chinese medicine extract. The traditional Chinese medicine extract comprises, by weight, 5-9 parts of Oldenlandia diffusa, 4-6 parts of perfoliote knotweed herb, 7-11 parts of mangosteen peel, 15-17 parts of fresh fig, 8-15 parts of fresh herba portulacae, 6-8 parts of radix zanthoxyli leaf, 4-6 parts of radix sophorae flavescentis, 4-6 parts of cowherb seed, 2-5 parts of euphorbia humifusa, 5-8 parts of Lycium ruthenicum, 1-3 parts of Pilea japonica, 1-2 parts of Ainsliaea fragrans Champ., 2-3 parts of salviae miltiorrhizae and 3-5 parts of Turpinia formosana. The injection prepared by natural food materials and Chinese herbal medicine materials is safe, free of side effect, capable of replacing antibiotics, capable of effectively treating the mastitis of the female minks, capable of replenishing the nutrition needed by the female minks and capable of guaranteeing the healthy growth the female minks and young minks.

The invention discloses a traditional Chinese medicine composition for treating tympanites with the syndrome of accumulation and binding of water-heat, wherein the traditional Chinese medicine composition consists of following raw materials, by weight: 12-15 parts of oriental stephania root, 12-15 parts of bredia quadrangularis, 12-15 parts of stephania tetrandra, 15-18 parts of cyclosorus dentatus, 7-10 parts of dichocarpum auriculatum, 20-25 parts of cardamine hirsute, 20-25 parts of bidens pilosa, 20-25 parts of cynoglossum amabile roots, 12-15 parts of polygonum perfoliatum, 20-25 parts of potamogeton distinctus, 12-15 parts of roots of moghania fruticulosa, 8-10 parts of asiatic striga, 8-10 parts of herba inulae, 12-15 parts of herba eupatorii, 20-25 parts of commelina communis, 4-6 parts of radix glycyrrhizae, 10-12 parts of herbal ainsliaea fragrans and 20-25 parts of leersia hexandra. The traditional Chinese medicine composition can effectively cure the tympanites with syndrome of accumulation and binding of water-heat, and is high and good in curative effects.

The invention discloses a tissue culture technology breeding method of ainsliaea fragrans Champ. The method comprises the steps of selection of explants, cleaning and disinfection of the explants, induction of cluster buds, multiplication and rooting of the cluster buds and the like. According to the method, a tissue culture technology of ainsliaea fragrans Champ is explored, ideal culture conditions such as acquisition of an aseptic material, induction of calluses, differentiation of the calluses into buds and rooting are determined, finally, an asexual reproduction system of tissue culture seedlings of ainsliaea fragrans Champ is established, a technical foundation is laid for protecting and cultivating wild resources of ainsliaea fragrans Champ, meeting demands for seedlings and establishing a gene bank, and the problems of low yield, small supply amount and long natural cultivation cycle of wild panax japonicus majoris are solved.

The invention provides a method for preparing a traditional Chinese medicine preparation containing Ainsliaea fragrans extracts. The preparation comprises the Ainsliaea fragrans extracts, micro silicagel and water in parts by weight. The preparation method comprises the following steps: grinding the Ainsliaea fragrans extracts into fine powder and sieving the fine powder for standby use; grindingthe micro silica gel into fine powder, sieving the fine powder, adding water and mixing the fine powder with the fine powder of the extracts to prepare granules; directly tabletting and coating the granules, thus obtaining the preparation. The dose of the medicine prepared by the invention is greatly reduced and the compliance of the patients is improved; therefore, the preparation is favorable for clinical application.

The invention discloses traditional Chinese medicine composition for treating extensive heat type subacute eczema. The traditional Chinese medicine composition is prepared from hypericum japonicum, Chinese osbeckia herb, buttonbush roots, roots of pilular adina, all grass of ainsliaea fragrans champ, straightstalk alpine meadowrue roots, multibract raspberry roots, persicaria chinensis, senecio dianthus franch and kalanchoe laciniata. A clinical test shows that the traditional Chinese medicine composition has functions of exudation resistance and reduction of celluar edema by reducing capillary permeability and plays a role in inhibiting cell proliferation and irritability inflammatory reaction in different degrees, the total effective rate reaches 96%, and the curative effect is remarkable.

The invention relates to an extract of frangrant ainsliaea herb total phenolic acids and the preparation method thereof, after the medicinal materials of frangrant ainsliaea herb are extracted by 70% ethanol through reflux, the ethanol extract is concentrated to small volume and the ethanol content in the solution is controlled to be 20% - 40%, after the pH is adjusted to be 1-3 by hydrochloric acid, the solution stands still and is filtered, then the solution is clear and concentrated, the material obtained is put on a macroporous absorption resin column and eluted by ethanol after washed, and then ethanol eluent is collected, concentrated and dried, thus the extract of the invention is obtained. The content of total phenolic acids in the extract can be up to over 60%, and the chlorogenic acid in the extract can be more than 3%. The extract of the invention has the effects of antiinflammatory action and can be used for preparing the drugs that can treat gynae phlegmasia.

The invention discloses a traditional Chinese medicinal composition for treating pertussis. The traditional Chinese medicinal composition comprises, by weight, 5-7 parts of radish seed, 2-4 parts of Poria cocos, 1-3 parts of Poria cum Ligno Hospite, 8-10 parts of Radix Platycodonis, 5-7 parts of almond, 2-4 parts of honey-fried licorice root, 8-10 parts of Arisaema Cum Bile, 2-4 parts of root of Tomentoseflower Larkspour, 1-3 parts of Common Coltsfoot Flower, 6-8 parts of tangerine pith, 2-4 parts of Hedyotis diffusa, 6-8 parts of Sanicula lamelligera Hance, 2-4 parts of honeycomb, 1-3 parts of rhizome of Black Bamboo, 2-4 parts of Spora Lygodii, 2-4 parts of common nandina fruit, 6-8 parts of Cogongrass rhizome, 2-4 parts of White Mulberry Root-bark, 1-3 parts of Acorus gramineus, 1-2 pars of Acer buergerianum, 1-2 parts of Artemisia japonica, 1-2 parts of Anisodus mairei, 3-5 parts of Ainsliaea fragrans Champ. and 10-12 parts of amaranth stem. The traditional Chinese medicinal composition has the efficacies of sweating, cold dispelling, lung diffusing, panting calming, lung moistening, cough relieving, middle energizer warming, yang reviving, lactation promoting, dampness eliminating and phlegm dispersing, and has the advantages of good pertussis treatment effect, fast effectiveness, and no toxic side effects.

The invention belongs to the technical field of traditional Chinese medicine extracts, and particularly to an application of a compound ainsliaea fragrans champ extract in preparation of health products or drugs for prevention and treatment of liver injury. According to the present invention, liver protection effects of the ethanol extract and the water extraction alcohol precipitation extract of compound ainsliaea fragrans champ are investigated and confirmed, and the extracts can be used for prevention and treatment of liver injury.

The invention provides a traditional Chinese medicinal preparation for treating gynecological inflammation. The traditional Chinese medicinal preparation comprises Ainsliaea fragrans Champ., Glabrous Greenbrier Rhizome, Herba Leonuri, coix seed, Spina Gleditsiae, Herba Lycopi, Fructus Liquidambaris, safflower, ground beetle, Chinese angelica and Ligusticum wallichii. The traditional Chinese medicinal preparation has the advantages of symptomatic medication and treatment, scientific and reasonable composition, low cost, safety, no toxic side effect, fast effectiveness and use convenience.

The invention relates to the field of traditional Chinese medicine, in particular to traditional Chinese medicine for treating tuberculosis. Each dose of the traditional Chinese medicine for treating tuberculosis comprises the following medicinal herbs: 25 g of lily, 25 g of ainsliaea fragrans Champ., 25 g of radix stemonae, 25 g of bletilla, 25 g of humulus japonicus, 25 g of lucid asparagus, 15 g of cortex lycii radicis, 15 g of dwarf lilyturf turber, 30 g of heartleaf houttuynia herb, 30 g of siegesbeckia glabrescens makino, 25 g of petelot habenaria, 25 g of walnut kernel, 10 g of ginkgo, 15 g of osbeckia opipara, 10 g of longspur epimedium, 30 g of semen coicis, 25 g of alpinia japonica, 25 g of ceylon cynoglossum, 30 g of cirsium japonicum, 20 g of bistort, 50 g of cynoglossumfurcatum Wall., 15 g of Chinese arbor-vitae branches, 30 g of pilea notata and 30 g of liquorice. The traditional Chinese medicine for treating tuberculosis adopts the various traditional Chinese medicines to condition lungs, has the efficacies of nourishing yin, moistening lung, suppressing cough, reducing phlegm, cooling blood, stopping bleeding, removing blood stasis to regenerate tissues, regulating the flow of qi, relieving pain, benefiting a liver and kidneys, resisting bacterium, tonifying deficiency, and enhancing immunity, not only can resist tuberculosis from the source, but also can protect the lever, has obvious effects in treating symptoms such as cough, expectoration, hemoptysis and chest pain of tuberculosis, is free of toxic and side effects, and high in safety, and can treat both symptoms and root causes.

The invention discloses a traditional Chinese medicine composition for treating yin deficiency lung dryness type cephalomenia, and belongs to the field of traditional Chinese medicines. The deficiency lung dryness type cephalomenia has symptoms of heart-fire hyperactivity, internal heat stasis, lung and collateral damage, heat-damaged blood and blood retrogradation caused by normal body weakness and yin deficiency, sadness and over thoughtfulness. When menstruation approaches or already happens, the menstruation blood can be retrogradated upwards because of internal heat, and then cephalomenia can be caused. Under the instruction of traditional Chinese medicine theories and clinical experience and on the basis of pathogenesis, the traditional Chinese medicine composition is prepared from traditional Chinese medicines such as cortex lycii radicis, reed rhizome, juncus effuses, rohdea roots, ainsliaea fragrans, herba tripterospermi, herb of flaccid aster, tatarian aster root, polygonatum cirrhifolium root of dwarf burnet and balanophora polyandra. The traditional Chinese medicine composition is reasonably formulated according to the principle of assistant and guide, has the advantages of being scientific in formulation, good in specificity, definite in treatment effect, small in side effect and the like, has the effects of clearing lung to remove heat, cooling blood to stop bleeding, ensuring proper downward flow of the blood, moistening lung to nourish yin, enriching yin to nourish kidney, tonifying spleen, nourishing stomach as well as enriching blood and regulating menstruation as the medicines cooperate with one another and the medicinal properties are linked with one another, and is worthy of clinical popularization.

The invention discloses a traditional Chinese medicinal composition for treating pertussis. The traditional Chinese medicinal composition comprises, by weight, 5-7 parts of radish seed, 2-4 parts of Poria cocos, 1-3 parts of Poria cum Ligno Hospite, 8-10 parts of Radix Platycodonis, 5-7 parts of almond, 2-4 parts of honey-fried licorice root, 8-10 parts of Arisaema Cum Bile, 2-4 parts of root of Tomentoseflower Larkspour, 1-3 parts of Common Coltsfoot Flower, 6-8 parts of tangerine pith, 2-4 parts of Hedyotis diffusa, 6-8 parts of Sanicula lamelligera Hance, 2-4 parts of honeycomb, 1-3 parts of rhizome of Black Bamboo, 2-4 parts of Spora Lygodii, 2-4 parts of common nandina fruit, 6-8 parts of Cogongrass rhizome, 2-4 parts of White Mulberry Root-bark, 1-3 parts of Acorus gramineus, 1-2 pars of Acer buergerianum, 1-2 parts of Artemisia japonica, 1-2 parts of Anisodus mairei, 3-5 parts of Ainsliaea fragrans Champ. and 10-12 parts of amaranth stem. The traditional Chinese medicinal composition has the efficacies of sweating, cold dispelling, lung diffusing, panting calming, lung moistening, cough relieving, middle energizer warming, yang reviving, lactation promoting, dampness eliminating and phlegm dispersing, and has the advantages of good pertussis treatment effect, fast effectiveness, and no toxic side effects.

The invention discloses a breeding method of apricot rabbit ear wind, which comprises the following steps: gathering seed; grading; making bed; sowing; managing; fertilizing 50-100kg compound fertile or 100-150kg matured compost as base fertile.

The invention provides a traditional Chinese medicine ointment for treating lung cancer and a preparation method of the traditional Chinese medicine ointment. The traditional Chinese medicine composition is prepared from the following raw materials: manyleaf paris rhizome, barbed skullcap herb, heartleaf houttuynia herb, nux vomica, spanish fly, coix seed, ainsliaea fragrans, uniflower swisscentaury root, honeycomb, lance asiabell root, black nightshade herb, solanum lyratum, fruticose dracaena leaf, snakegourd fruit, rhizoma pinelliae preparata, salvia chinensis, paris polyphylla, rhizoma bolbostemmae, selaginella doederleinii hieron, Indian strawberry, vietnamese sophora root, livistona chinensis seed, catechu, venenum bufonis, java brucea fruit, scorpion, acorus calamus, selfheal, walnut branch and cordyceps sinensis. The traditional Chinese medicine ointment disclosed by the invention has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, reducing swelling and resolving mass, relieving cough and reducing sputum, clearing damp, tonifying qi and nourishing blood, and tonifying kidney and lung, and has a good curative effect in the aspect of treating lung cancer.

The invention provides a preparation method of a frangrant ainsliaea herb soft capsule. The frangrant ainsliaea herb soft capsule is prepared from 3,000 g of frangrant ainsliaea herb serving as bulk drugs through microwave extraction. The content is greatly increased, and the dosage is reduced. The invention further provides an application of the frangrant ainsliaea herb soft capsule in preparing red blood cell increase drugs and anti-hypoxia drugs.

The invention provides a quality control method for an extraction process of Chinese medicine ainsliaea fragrans champ, and the quality control method comprises the following steps: firstly, measuring the content of chlorogenic acid in a qualified ainsliaea fragrans champ extract solution and acquiring a near-infrared spectrum; secondly, respectively establishing a corresponding model between thenear-infrared spectrum and the content of the chlorogenic acid in the ainsliaea fragrans champ extract solution by adopting chemometric software; thirdly, measuring the near-infrared spectrum of a chlorogenic acid sample of which the content is to be measured; and fourthly, by using the corresponding model, respectively acquiring the content of the chlorogenic acid in the chlorogenic acid sample of which the content is to be measured through the chemometric software.