Method for extracting and further processing ainsliaea fragrans total flavonoid

A technology of apricot fragrant rabbit wind and total flavonoids is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc. It can reduce energy consumption and production costs, simplify the extraction and preparation process, and accelerate dissolution and diffusion.

Inactive Publication Date: 2016-02-03
JIANGXI KINGSTONE UNITE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, the patent applications or authorizations related to the extraction method of apricot rabbit ear wind mainly include: Chinese Patent Publication No.: CN101380347A discloses an invention patent named "Xingxiang rabbit ear wind total flavonoid extract and its extraction method and use", The traditional ethanol reflux extraction and macroporous adsorption resin separation technology are used to obtain the total flavonoids extract of apricot rabbit ear wind. This method is easy to destroy heat-sensitive components, and more organic solvents are used, which is prone to organic solvent residues and affects the quality of the drug. And the operation is comparatively loaded down with trivial details, and the production cost is higher; Chinese patent authorization announcement number: CN101293003B discloses the invention patent called " a kind of apricot-flavored rabbit wind effective part and its preparation method and application ", is firstly extracted by ethanol percolation, and then Petroleum ether and ethyl acetate were added successively for extraction, and finally the total phenolic acid components were obtained; Chinese patent authorization announcement number: CN101332216B discloses an invention patent named "Xingxiang rabbit wind total phenolic acid extract and its preparation method", which is also Through the traditional ethanol reflux extraction, and use hydrochloric acid to adjust the pH and separate the macroporous adsorption resin to obtain the total phenolic acid of apricot rabbit ear wind; Acid extract and its preparation and application" invention ...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Pretreatment of raw medicinal materials: crush the raw medicinal materials of Xingxiangtuerfeng into raw medicinal powder with a medicinal grinder;

[0020] Ultrasonic countercurrent extraction: Put 1 kg of the original drug powder into a continuous single-stage countercurrent ultrasonic extraction machine, add 50% ethanol aqueous solution that is 8 times the amount of the original drug powder, and conduct ultrasonic countercurrent extraction for 30 minutes at room temperature with an ultrasonic power of 80KHz, and filter the extract , collect the filtrate and filter residue, repeat the ultrasonic countercurrent extraction of the filter residue twice, and filter after each extraction, and combine the filtrate;

[0021] Concentration: Concentrate the filtrate at a vacuum degree of 0.85-0.95Mpa and reduce pressure at 60°C to form a clear paste with a relative density of 1.25;

[0022] Alcohol precipitation: Add 80% ethanol solution with 6 times the amount of the clear oin...

Embodiment 2

[0027] Pretreatment of raw medicinal materials: crush the raw medicinal materials of Xingxiangtuerfeng into raw medicinal powder with a medicinal grinder;

[0028] Ultrasonic countercurrent extraction: Put 1 kg of the original drug powder into a continuous single-stage countercurrent ultrasonic extraction machine, add 50% ethanol aqueous solution that is 8 times the amount of the original drug powder, and conduct ultrasonic countercurrent extraction for 40 minutes at room temperature with an ultrasonic power of 60KHz, and filter the extract , collect the filtrate and filter residue, repeat the ultrasonic countercurrent extraction of the filter residue 3 times, and filter after each extraction, and combine the filtrate;

[0029] Concentration: Concentrate the filtrate under reduced pressure at 0.85-0.95Mpa at a vacuum degree of 60°C to form a clear paste with a relative density of 1.20;

[0030] Alcohol precipitation: add the concentrated clear cream to 80% ethanol solution of ...

Embodiment 3

[0035] Pretreatment of raw medicinal materials: crush the raw medicinal materials of Xingxiangtuerfeng into raw medicinal powder with a medicinal grinder;

[0036] Ultrasonic countercurrent extraction: Put 1 kg of the original drug powder into a continuous single-stage countercurrent ultrasonic extraction machine, add 50% ethanol aqueous solution that is 8 times the amount of the original drug powder, ultrasonic countercurrent extraction at room temperature with an ultrasonic power of 40KHz for 45 minutes, and filter the extract , collect the filtrate and filter residue, repeat the ultrasonic countercurrent extraction of the filter residue 3 times, and filter after each extraction, and combine the filtrate;

[0037] Concentration: Concentrate the filtrate under reduced pressure at 0.85-0.95Mpa at a vacuum degree of 60°C to form a clear paste with a relative density of 1.05;

[0038] Alcohol precipitation: Add the concentrated clear cream to 80% ethanol solution of 6 times the ...

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Abstract

The invention relates to the technical field of Chinese pharmaceutical manufacturing, particularly to a method for extracting and further processing ainsliaea fragrans total flavonoid. With ainsliaea fragrans adopted as the raw medicinal material, the method comprises the following steps: firstly, smashing ainsliaea fragrans; carrying out ultrasonic immersion extraction on the smashed ainsliaea fragrans in ethanol water for a plurality of times; then, combining extracting solutions; decompressing and concentrating the extracting solutions; adding ethyl alcohol into the concentrated solution, and carrying out low-temperature standing for alcohol precipitation; filtering with a micropore filter membrane; decompressing and concentrating the filtrate; carrying out vacuum drying on the concentrated solution to obtain refined ainsliaea fragrans total flavonoid extract; finally, adding pharmaceutical excipients for further preparing the ainsliaea fragrans total flavonoid extract into various pharmaceutical preparations. According to the method, ultrasonic wave and continuous countercurrent extraction technologies are combined, so that the dissolution and spreading of the effective components are quickened, the extraction time is greatly shortened, the extraction efficiency is improved, the degradation of heat sensitive components is avoided, the energy consumption and production cost are further reduced, the extraction preparation technology is relatively simple and convenient, and the method is applicable to industrial large-scale production.

Description

technical field [0001] The invention belongs to the technical field of extraction and deep processing of traditional Chinese medicines, and in particular relates to a method for extracting and deep processing total flavonoids of apricot and rabbit rhizome. Background technique [0002] Apricot rabbit ear wind is the dry whole herb of Ainsliaea fragrans Champ (Ainsliaea fragrans Champ). Apricot Fragrant Rabbit Wind has the functions of clearing heat and detoxifying, dispelling stagnation, relieving cough, and stopping bleeding. It is often used for upper respiratory tract infection, lung abscess, tuberculosis hemoptysis, jaundice, infantile malnutrition, indigestion, mastitis, otitis media, acute and chronic Treatment of cervicitis and snake bites, etc. Xingxiang Tuerfeng is a commonly used folk medicine, but there are not many research reports in the literature at present. Its chemical components are mainly divided into flavonoids, terpenoids and phenolic acids, etc., all o...

Claims

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Application Information

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IPC IPC(8): A61K36/28
Inventor 谢棋李旭刘路加郭峰
Owner JIANGXI KINGSTONE UNITE PHARMA CO LTD
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