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Method for simultaneously producing honeysuckle flower distillate and various active substances

A technology for honeysuckle dew and active substances, which is applied in the field of chemical substances or pharmaceutical manufacturing, can solve the problems that separation technology is difficult to scale up for production, consumes organic solvents, low utilization rate of raw materials, etc. Effect

Inactive Publication Date: 2013-02-20
HUBEI CHUTIANSHU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The invention provides a method for synchronously producing honeysuckle dew and various active substances with honeysuckle, which solves the problem that the existing extraction and preparation of chlorogenic acid consumes a large amount of organic solvents and causes environmental pollution; or it is difficult to scale up production by using relatively complicated separation techniques; Or the extraction efficiency is not high, the utilization rate of raw materials is low, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Underpressure distillation step:

[0025] Add 10kg of dried honeysuckle in the distillation pot as raw material, and add 500L of water, the volume-mass ratio of the added water to the raw material is 50:1 (L / kg), distill under reduced pressure at 0.08MPa, 60°C, and collect 160L fraction To obtain honeysuckle dew, the mass ratio of the collected fraction volume to the honeysuckle dry product raw material is 16:1 (L / kg); simultaneously collect 260L of residual liquid in the still.

[0026] (2) Precipitation and separation step

[0027] With 260L of distillation raffinate obtained in step (1), add 2.6kg chitosan as flocculant, the mass volume ratio of the quality of added precipitation agent and distillation raffinate is 1: 100 (kg / L), after stirring 30min , stood at room temperature for 12 hours, filtered to obtain the precipitate, and dried to obtain 425.60 g of honeysuckle polysaccharide. Collect and filter supernatant 240L, which is the precipitation separation l...

Embodiment 2

[0034] (1) Underpressure distillation step:

[0035] Add 10kg of honeysuckle dry product in the distillation pot as raw material, and add 200L of water, the volume mass ratio of added water to raw material is 20:1 (L / kg), distill under reduced pressure at 0.1MPa, 70°C, and collect 100L fraction To obtain honeysuckle dew, the mass ratio of the collected fraction volume to the honeysuckle dry product raw material is 10:1 (L / kg); simultaneously collect 70L of residual liquid in the still.

[0036] (2) Precipitation and separation step

[0037] With the distillation raffinate 70L that obtains in the step (1), add 0.4kg chitosan as flocculant, the mass volume ratio of the quality of the precipitating agent added and distillation raffinate is 2: 100 (kg / L), after stirring 20min , stood at room temperature for 8 hours, filtered to obtain the precipitate, and dried to obtain 407.65 g of honeysuckle polysaccharide. Collect and filter supernatant 65L, which is the precipitation separa...

Embodiment 3

[0044] (1) Underpressure distillation step:

[0045] Add 20kg of honeysuckle dry product as raw material in the still, and add 600L of water, the volume mass ratio of added water to raw material is 30:1 (L / kg), distill under reduced pressure at 0.09MPa, 65 ℃, collect 240L fraction To obtain honeysuckle dew, the mass ratio of the collected fraction volume to the honeysuckle dry product raw material is 12:1 (L / kg); simultaneously collect 330L of residual liquid in the still.

[0046] (2) Precipitation and separation step

[0047] With 330L of the distillation raffinate obtained in step (1), add 3.3kg of poly(phenylene amide) as a flocculant, the mass-volume ratio of the added precipitant to the distillation raffinate is 1:100 (kg / L), and stir for 10min Afterwards, stand at room temperature for 6 hours, filter to obtain the precipitate, and obtain 815.50 g of honeysuckle polysaccharide after drying. Collect and filter supernatant 310L, which is the precipitation separation liqu...

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PUM

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Abstract

The invention relates to a method for simultaneously producing honeysuckle flower distillate and various active substances. The invention relates to a method for simultaneously producing various physiologically active substances such as honeysuckle flower distillate, honeysuckle flower polysaccharide and chlorogenic acid by using honeysuckle flowers as a raw material. The method comprises the steps of vacuum distillation, precipitation separation, macroporous resin separation, and silica gel column separation. The method has the advantages of reasonable design, simple method, and easy popularization. In prior arts, a large amount of organic solvents are adopted for extracting and preparing chlorogenic acid, such that environment pollution is caused; also, the purity is not high, production cost is high, and production efficiency is low. With the method, the problems are solved, and various by-products obtained during honeysuckle flower distillate production process can be comprehensively utilized. Therefore, various physiologically active substances such as honeysuckle flower polysaccharide, high-purity chlorogenic acid, 2-caffeoylquinic acid, 3,4-caffeoylquinic acid and the like are obtained. Therefore, production cost is saved, production efficiency is improved, the process is simple, and the process can easily be applied in industrialized productions. Therefore, raw material utilization rate can be greatly improved.

Description

technical field [0001] The invention belongs to a manufacturing method of chemical substances or medicines, and in particular relates to a method for synchronously producing various physiologically active substances such as honeysuckle dew, honeysuckle polysaccharide, and chlorogenic acid by taking honeysuckle as a raw material. Background technique [0002] Honeysuckle has a long history of medicinal use. It is a commonly used heat-clearing and detoxifying drug, and it is widely planted in many regions of the country. Since ancient times, honeysuckle has been widely used as a medicinal plant, and it was fully recognized by the market during the "SARS" period. Therefore, products developed from honeysuckle have a very good market prospect. [0003] At present, domestic manufacturers only simply produce honeysuckle tea and honeysuckle dew or only extract the active ingredient chlorogenic acid in honeysuckle. Chlorogenic acid is a depsipated acid produced by caffeic acid (Caf...

Claims

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Application Information

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IPC IPC(8): A61K36/35C07C69/732C07C67/48C08B37/00A61P43/00A61P17/00A61P31/04A61P31/12A61P7/00A61P15/00A61P9/12A61P35/00A61P37/04A61P39/06A61P7/10A61P1/16A61P3/06A61P15/06
Inventor 向福叶冬三向俊叶新潮闫立新
Owner HUBEI CHUTIANSHU PHARMA
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