218results about How to "Easy to scale up industrial production" patented technology

This invention relates to a method for preparing olivine-type phosphate-series lithium ion battery anode material. The method comprises: mixing one or more of ferrous salt solution, cobalt salt solution and manganese salt solution with oxalic acid or oxalate (precipitating agent) aqueous solution to obtain composite oxalate precursor, uniformly mixing with lithium source and phosphorus source by ball milling, and reacting in inert or weak-reductive atmosphere to obtain olivine-type phosphate-series lithium ion battery anode material. The method utilizes co-precipitation method for metal ion doping, and realizes molecular level uniform mixing among different ions. The obtained olivine-type phosphate-series lithium ion battery anode material has uniform chemical and physical compositions. The average particle size can be controlled within 0.3-10 mu.m. The first charge and discharge cycle specific capacity can reach 150 mAh/g at 0.1 C rate and room temperature. The livine-type phosphate-series lithium ion battery anode material has such advantages as high cycle performance and high charge/discharge performance.

The invention discloses a preparation method of polymer microballoon sphere with uniform size, which can dissolve biodegradable polymer material in at least one organic solvent to form an O phase, and then adds the optional aqueous solution W1 containing medicine or medicine granule S into a fat phase O for emulsification to prepare colostrum; the obtained colostrum is added into an outer water phase W containing stabilizing agent to form pre-compound emulsion; then, the pre-compound emulsion is pressed through a microporous film by pressure to obtain compound latex; at last, after being solidified, the compound latex is centrifugated, washed, frozen and dried, so as to obtain the polymer microballoon sphere. The method of the invention is simple in technique, uniform in the grain diameter of the obtained product, good in repetitiveness of each batch product and easy in commercial process.

The invention relates to a manufacturing method for ordered medium aperture alumina that includes the following steps: adding surface activator into inorganic aluminum salt as template agent, making precipitant solution, adding inorganic aluminum salt solution into hypergravity reactor, adding precipitant, when the reacting solution reaching a certain pH value, the precursor sol would be gained; taking aging, filtering, washing, and drying to the precursor sol to gain precursor powder. The powder could be made into ordered medium aperture alumina after taking sintering. The invention has the advantages of simple technology, safe to operate, low cost, etc. The specific surface of the product reaches 250-300m2/g, and the shape has certain orderliness. It has crucial application value in adsorption and catalyzing process.

The invention discloses a method for preparing an ultracapacitor-used porous grapheme material, and belongs to the technical field of carbon material preparation. According to the method, coal pitch is used as the carbon source, nanometer calcium carbonate is used as a template, and potassa is used as an activating agent; the three components are ground in a dry method; the mixture is transferred to a corundum ceramic boat, is placed in a pipe furnace, and is subjected to heating activation under a normal pressure condition or a negative pressure condition to directly obtain the ultracapacitor-used porous grapheme material. The method adopts cheap coal pitch and nanometer calcium carbonate as the raw materials, and has the advantages being simple in technology, low in cost, suitable for industrialized production and the like; the material has a specific surface area within the range of 1330-1946 m<2>/g and an average aperture within the range of 2.32-3.08 nm, and can exhibit relatively high volume and energy intensiveness when being used as an electrode material of an ultracapacitor.

The invention relates to a butylphthalide synthesis method. The method comprises the steps that methyl 2-formyl benzoic acid is adopted as a starting material, THF is adopted as a solvent to react with an n-butyl magnesium chloride Grignard reagent, and acid regulation is performed to prepare a butylphthalide product. The invention further relates to a technology for preparing high-purity butylphthalide. The obtained crude butylphthalide product is subjected to hydrolysis treatment by an alkaline substance, acid regulation is performed to separate out solids, and filtering is performed to obtain a butylphthalide midbody; the acid regulation and alkali regulation processes are executed repeatedly, and finally ring closure and decompression desolvation are performed to obtain high-purity butylphthalide. According to the synthesis method, low-flash diethyl ether is prevented from being adopted as a solvent, the purification technology is easy to implement, the reagent can be purchased in bulk easily, column chromatography product purification and reduced pressure distillation under high temperature and high vacuum degree are not needed, and industrial enlarged production is easy.

The invention discloses a new method for preparing polyaspartic acid hydrogels, which comprises the following steps: preparing crosslinking and hydrolysis method-prepared crosslinked polyaspartic acid hydrogels by using polysuccinimide as a raw material and by using a heterogeneous suspension crosslinking method; and drying the crosslinked polyaspartic acid hydrogels to obtain solid polyaspartic acid hydrogel powder. In the step of preparing the crosslinking and hydrolysis method-prepared crosslinked polyaspartic acid hydrogels by using the heterogeneous suspension crosslinking method, a crosslinker and an alkaline mixture for hydrolysis are added into suspension of the polysuccinimide under a condition of the temperature of 10 below zero DEG C to 50 DEG C to perform crosslinking and hydrolysis at the time, and the reaction products are dried to obtain the polyaspartic acid hydrogels. The method has the advantages of simple preparation process, organic solvents are not used in the reaction processes, environment is protected, and the prepared polyaspartic acid hydrogels have high water absorption capacity and high anti-salt capacity. The invention belongs to the field of hydrogel preparation.

The invention relates to itraconazole composite powder and a preparation method thereof. The method comprises the following steps: dissolving itraconazole medicine into an organic solvent; adding the mixture of the itraconazole medicine and the organic solvent into a water solution with hydrophilic accessory ingredients for in-situ precipitation to separate out medicine; obtaining the nanometer amorphous itraconazole medicine grain turbid liquor; carrying out spraying drying or freeze drying on the obtained itraconazole medicine turbid liquor to obtain micron level itraconazole high molecular accessory ingredient composite powder; and then, dispersing the powder into water to obtain the uniform nanometer amorphous itraconazole medicine grain turbid liquor. The itraconazole high molecular accessory ingredient composite powder has good water-solubility and high dissolution speed, in addition, the operation is simple, the amplification is easy, the production cost is low, and the invention lays the foundation for the industrial production of the itraconazole medicine and the development and the utilization of novel preparations of the itraconazole medicine.

The invention provides an industrialized production method for high-purity decitabine. The method comprises the following steps of: 1, performing silanization reaction of 5-azacytosine, bis(trimethylsilyl)amine and trimethyl chlorosilane, which serve as raw materials, to prepare 2,4-bis(trimethylsilyl)-5-azacytosine; 2, performing reaction of the product obtained by the step 1 and 1-chloro-3,5-bis-(4-chlorobenzoyl)-2-deoxy-D-ribofuranose, which serve as raw materials, to prepare a crude product of 1-(3,5-bis-(4-chlorobenzoyl)-2-deoxy-beta-D-ribofuranose)-5-azacytosine; 3, dissolving the product obtained by the step 2 in a C5 to C7 hydrocarbon, stirring, filtering and drying to obtain a refined product; and 4, producing the high-purity decitabine by using the product obtained by the step 3, methyl alcohol and sodium methoxide as raw materials. The method overcomes the disadvantages of need of column purification, low purity, difficult industrial production in the prior art, and has the advantages of simple and convenient operation, small solvent consumption, small influence on the environment, low labor intensity, short period, high product purity, single impurity and less than 0.1 percent total impurity content.

The invention relates to a supported nickel-based catalyst and a preparation method thereof. The active ingredient of the catalyst is nickel, and the nickel accounts for 5 to 30 percent of the total mass of the catalyst; and silica, active carbon, silica gel, a molecular sieve or alumina is taken as a carrier. In the preparation method, the active ingredient is supported on the surface of the carrier by a solid-phase dispersion method, the dispersibility of the active ingredient is improved and the interaction force between the active ingredient and the carrier is enhanced through the heat treatment process, and a catalyst precursor is reduced through the liquid phase reduction process. Compared with the traditional immersion method, the method has the advantages that: a filtering and drying step is saved, the operating process is more simple, the catalyst preparation cost is low, the energy consumption is low, the method is environment-friendly, the activity of the prepared catalyst is equal to that of the catalyst prepared by the immersion method, and the method is suitable for industrial amplification production of the supported nickel-based catalyst.

The invention relates to the field of preparation of porous microspheres, in particular to porous microspheres for medicine carriers, a preparation method and a medicine loading method. The method comprises the following steps of: 1) dissolving a degradable di-block amphiphilic polymer material in an organic solvent to form an oil phase O; 2) adding the oil phase O into a water phase W which contains a stabilizing agent to form O/W pre-emulsion; 3) allowing the O/W pre-emulsion obtained in the step 2 to pass through a microporous membrane to obtain O/W emulsion; and 4) removing the organic solvent from the emulsion obtained in the step 3, and curing, performing centrifugal washing and freeze drying to obtain porous medicine carrying microspheres. The organic solvent in the step 1) at least comprises a solvent of which the solubility in water is less than 2 percent; and the volume ratio of the oil phase O to the water phase W is 1:5-20. The porous microspheres overcome the problem thatthe conventional sustained release microspheres cannot be completely released at a later stage, and can effectively keep the medicine activity in the processes of carrying, storing and releasing the medicines.

The invention discloses a narcotic analgesic-loaded sustained-release microsphere and a preparation method thereof and application thereof. The narcotic analgesic-loaded sustained-release microspherecan be continuously released for 1 to 7 days, the burst release rate is less than 20% within 0.5 hour, and the drug embedding rate is higher than 80%, so that high drug embedding rate and low burst release rate and sustained release can be realized. The method has simple process, the obtained product has uniform particle size, batches of products have good repeatability, and the preparation methodis easy for industrial production.

The invention discloses a construction and application of a recombinant strain converting L-threonine to L-2-aminobutyric acid, belonging to the field of bioengineering technology. The production method of the invention utilizes a recombinant bacterium expressing two plasmids to simultaneously realize the high-efficient expression of three enzymes, and comprises the steps of: conversion of L-threonine to L-2-aminobutyric acid, coupled with a coenzyme regeneration system, converts NAD+ into NADH, so that the concentration of NADH in the system is relatively stable, and the conversion can be carried out efficiently. Furthermore, the CO<2> converted from ammonium formate can be dissolved in ammonia water, which has little environmental pollution and industrial application value. The method has the advantages of mild conversion condition, strong specificity, low cost and short conversion time. The L-2-aminobutyric acid is prepared adopting the method, 40g/L L-threonine is added, The concentration of the obtained product L-2-aminobutyric acid is 43.3 g/L, and the conversion ratio was over 99.9%.

The invention provides a method for preparing a food-grade lutein crystal from a marigold extract. The method comprises the following steps of: performing a saponification reaction on the marigold extract in a food-grade lower alcohol solvent by adding a solid alkali; diluting; then cooling and crystallizing; regulating the pH value; filtering; washing by adding an alcohol-water solution; and drying by adding a small amount of antioxidant, thereby obtaining lutein crystal powder. According to the method, the process is simple; the adopted solvent is recycled after being distilled, so that the treatment cost is low. Thus, the method is liable to industrial production. As the method is used, the defects of the existing lutein preparation method that the cost is high, the process is complicated, the time consumption is long and the lutein ester is unstable by performing reactions via harmful organic solvents under an acidic condition and at a high temperature are overcome. For the prepared lutein crystal, the actual yield is greater than 85%; and the purity reaches 80% to 90%. The prepared lutein crystal can be further prepared into an oil suspension or micro capsule powder which is applied to the fields of food additives, food supplements, functional foods and the like.

The invention discloses selenium-enriched bacillus bifidus micro-capsules. The selenium-enriched bacillus bifidus micro-capsules are prepared by adopting a method comprising the following steps: uniformly mixing a sodium alginate solution with selenium-enriched bacillus bifidus thallus and calcium carbonate powder so as to obtain a mixture; dropwise adding the mixture into vegetable oil containingan emulsifier, and carrying out stirring so as to obtain an emulsion; sequentially adding vegetable oil containing glacial acetic acid and an emulsifier solution into the emulsion, carrying out stirring, and allowing standing; and then, separating oil phase so as to obtain aqueous phase, and centrifuging the aqueous phase so as to obtain the selenium-enriched bacillus bifidus micro-capsules. By screening reagents, materials and dosage ratio adopted in micro-capsule preparing, coating and freeze-drying processes, embedding rate of the selenium-enriched bacillus bifidus micro-capsules disclosedby the invention are improved. The embedding rate of the selenium-enriched bacillus bifidus micro-capsules is up to 98% while the particle size is smaller than 200 microns and the freeze-drying survival rate is up to 85%. According to normal-temperature stability results, viable number of the selenium-enriched bacillus bifidus micro-capsules is still about 10<8> cfu/g within 180 days.

The invention provides a methylene methanedisulfonate synthesis method. The methylene methanedisulfonate synthesis method comprises the following preparation steps: adding methane-disulfonic acid and paraformaldehyde to a reaction vessel, stirring and mixing, then adding anhydrous magnesium sulfate, heating to 70-100 DEG C, carrying out isothermal reaction for 5-8 hours, cooling to room temperature, extracting solids by using dichloromethane, filtering to remove insoluble substances, and carrying out spin dry on a filtrate to obtain white methylene methanedisulfonate. The methylene methanedisulfonate synthesis method has the beneficial effects that a novel dehydrating agent is used, thereby causing reaction to be pure and environment-friendly; an organic solvent does not need to be added; the stirring of the system is easy; the reaction is complete, thereby improving the yield of the generated methylene methanedisulfonate; the reaction time is short; the aftertreatment is convenient; and the mass production can be realized simply and convenient.

The process of preparing superfine Azithromycin powder belongs to the field of superfine medicine powder preparing technology. Specifically, the process includes marketable Azithromycin medicine material in organic solvent to obtain Azithromycin solution, adding the Azithromycin solution in counter solvent in certain volume through magnetic stirring at certain temperature to deposit Azithromycin crystal and obtain crystal slurry, ageing at certain temperature, filtering, washing and drying to obtain superfine Azithromycin powder product. The process is simple, safe, low in cost and suitable for industrial production, and the obtained superfine Azithromycin powder has high leaching rate and high solubility.

The invention relates to a method for batch-preparing organized mesoporous alumina, which belongs to the nano structure material preparation field. In the method, a surface active agent is added to be used as a template agent after inorganic aluminum salting liquid is manufactured; precipitator liquid is confected at the same time; the confected precipitator is added at certain speed to obtain an inorganic precursor sol. The obtained inorganic precursor sol is processed through aging, then filtration, washing and drying to obtain inorganic precursor powders; the obtain inorganic precursor powders are calcined according to the set calcination process under nitrogen atmosphere to obtain the organized mesoporous alumina. The method has simple technology, safe operation and low cost, and is easy for industrialized enlarged production. The prepared mesoporous alumina has the advantages of large specific surface area (250 to 300m<2>/g), narrow pore-size distribution, vermiform pore canal, sequential size and shape, and important application value during the absorption and catalysis process.

The invention discloses a method for improving production efficiency of D-tyrosine, which belongs to the technical field of bioengineering. A double-plasmid co-expression recombinant bacterium is constructed through a molecular biological means, efficient expression of three enzymes is achieved at the same time, L-tyrosine is converted into D-tyrosine, NADP<+> is converted into NADPH through a coupling coenzyme regeneration system, and NADPH cyclic regeneration and conversion can be efficiently conducted, the efficient production of D-tyrosine is realized by optimizing whole-cell transformation conditions. The yield of the D-tyrosine produced by the method can reach 8.4 g/L, and the conversion rate reaches 93%.

The invention discloses an opioid receptor partial agonist supported sustained release microsphere as well as a preparation method and application thereof. The opioid receptor partial agonist supported sustained release microsphere has a drug embedding rate of higher than 80%, the initial burst release of the drug is lower than 20% within half an hour, and the drug can realize sustained release ata constant speed for 1-15 days. The preparation method disclosed by the invention is simple in process, the prepared product is uniform in particle size, the repeatability of each batch of products is excellent, industrial production is easily realized, the repeatability of the product is ensured, the curative effect of the drug is stable, the prepared microsphere has excellent re-suspending property in water, and industrial production cost is saved.

The invention relates to a crystal form B of 4, 5, 6, 7-tetrahydro-1-(4-methoyxl phenyl)-7-oxo-6-[4-(2-oxo-1-piperidyl) phenyl]-1H-pyrazolo[3,4] pyridine-3-formamide (apixaban). The X-powder diffraction pattern of the crystal form is shown in the figure. The crystal form is good in solubleness and can be prepared into a formulation which is qualified to dissolve out without controlling the granularity in a micronizing manner. Meanwhile, the invention further provides two methods for preparing the crystal form. One method comprises the following step: carrying out ammonolysis on ester groups of a compound A under the effect of formamide and sodium alkoxide under a proper organic solvent condition to obtain crystal form B of Apixaban. The preparation method is simple and convenient and easy to amplify for industrialized production. The other method comprises the step of obtaining the crystal form B of apixaban by a non-crystal form B apixaban product by way of dissolution and crystallization, so that the crystal form is convenient to convert.

The invention discloses a process for producing lignin diesel. The method is characterized by comprising the following steps of: uniformly mixing the components of an emulsifier in a ratio, forcibly dispersing the uniformly mixed emulsifier and diesel by a physical means to obtain a stable dispersing system, then adding assistant emulsifier and an oil modifier in a certain ratio, injecting decolored alkali lignin aqueous solution from which impurities are removed into the system at a constant speed, continuously dispersing cyclically for certain times, taking out and naturally settling for 1 to 2 days, and filtering to obtain supernate, namely the lignin diesel. In the process, the lignin diesel is prepared from the waste lignin used as raw materials instead of partial diesel. The process has the advantages of simplicity, easiness in amplification, and industrialization and the like.