Method for preparing polymer microsphere

A technology of polymers and polymer materials, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of poor preparation repeatability, inability to embed hemoglobin, and difficulty in controlling particle size and other problems, to achieve the effect of simple operation and expanding the scope of application

Active Publication Date: 2008-09-24
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional preparation methods use mechanical stirring, homogenization, and other methods to prepare emulsions. Although the process conditions are simple, the preparation repeatability is very poor, and there are large differences in performance between different batches of products, which is not easy for industrial scale-up production. The particle size uniformity is very poor, and the particle size is difficult to control
[0003] Chinese patent (publication number CN1605359) discloses a preparation method of polymer microspheres with uniform size for embedding hydrophilic drugs. , has high requirements on the stability of colostrum, and the preparation efficiency is low. In addition, organic so

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  • Method for preparing polymer microsphere
  • Method for preparing polymer microsphere

Examples

Experimental program
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Example Embodiment

[0049] Example 1

[0050] The hydrophilic SPG membrane with a pore size of 5.2 μm was soaked in water to make the pore membrane fully wet. Dissolve 10 mg of lysozyme in 2 mL of deionized water as the internal water phase, and dissolve 0.2 g of PLGA membrane material (molecular weight 30,000) in 4 mL of methylene chloride as the oil phase. The internal water phase and the oil phase are mixed, and ultrasonic emulsification is performed in an ice water bath for 15 seconds to obtain W / O colostrum. The colostrum was added to 40 mL of 1% wt PVA aqueous solution, magnetically stirred at 300 rpm for 30 seconds to prepare a pre-multiple emulsion, and then the pre-multiple emulsion was pressed through the microporous membrane device under an operating pressure of 300 kPa to obtain a double emulsion ( Optical Micrographs of Double Emulsion figure 2 (Shown), the emulsion membrane time is less than 1s, and then the double emulsion is stirred at room temperature for 24 hours to remove the orga...

Example Embodiment

[0053] Example 2

[0054] The hydrophilic SPG membrane with a pore size of 5.2 μm was soaked in water to make the pore membrane fully wet. Dissolve 0.2g PLGA membrane material (molecular weight 30,000) in 4mL dichloromethane as the oil phase, then add 10mg lysozyme solid particles into the oil phase, and ultrasonically emulsify for 15s in an ice water bath to obtain the S / O type initial milk. The colostrum was added to 40 mL of 1% wt PVA aqueous solution, magnetically stirred at 300 rpm for 30 seconds to prepare a pre-multiple emulsion, and then the pre-multiple emulsion was pressed through the microporous membrane device under an operating pressure of 300 kPa to obtain a double emulsion. Then, the double emulsion was stirred at room temperature for 24 hours to remove the organic solvent dichloromethane, and then washed by centrifugation to obtain drug-loaded microcapsules. The resulting microcapsules were vacuum dried for 48h to obtain finished microcapsules. The electron microsc...

Example Embodiment

[0055] Example 3

[0056] The hydrophilic SPG membrane with a pore size of 5.2 μm was soaked in water to make the pore membrane fully wet. With 0.8ml of 2mg / mL hepatitis B surface antigen solution as the internal water phase, 0.2g of polylactic acid-polyglycolic acid and polyethylene glycol copolymer (molecular weight 40,000, the ratio of polylactic acid to polyglycolic acid is 50 / 50, polyethylene glycol accounts for 20% mass fraction) dissolved in 4mL dichloromethane, as the oil phase, and then the internal water phase is added to the oil phase, ultrasonic emulsification in an ice water bath for 15 seconds to obtain W / O Type colostrum. The colostrum was added to 40mL of 1%wt PVA 0.9wt% NaCl aqueous solution, magnetically stirred at 300rpm for 30s to prepare a pre-multiplexed emulsion, and then the pre-multiplexed emulsion was pressed through the microporous membrane device under an operating pressure of 300kPa , The double emulsion is obtained, and the double emulsion is stirred...

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Abstract

The invention discloses a preparation method of polymer microballoon sphere with uniform size, which can dissolve biodegradable polymer material in at least one organic solvent to form an O phase, and then adds the optional aqueous solution W1 containing medicine or medicine granule S into a fat phase O for emulsification to prepare colostrum; the obtained colostrum is added into an outer water phase W containing stabilizing agent to form pre-compound emulsion; then, the pre-compound emulsion is pressed through a microporous film by pressure to obtain compound latex; at last, after being solidified, the compound latex is centrifugated, washed, frozen and dried, so as to obtain the polymer microballoon sphere. The method of the invention is simple in technique, uniform in the grain diameter of the obtained product, good in repetitiveness of each batch product and easy in commercial process.

Description

technical field [0001] The invention relates to a preparation method of polymer microspheres in the fields of medicine, biochemical industry, etc., more specifically, relates to a preparation method of rapidly preparing polymer microspheres with uniform size. Background technique [0002] Drug-loaded polymers play an important role in the controlled release system of drugs. The solvent evaporation / extraction method has been used to prepare drug microspheres for a long time, but most of them are still in the stage of laboratory research, and there are still many problems. This restricts the clinical application of microsphere preparations. Traditional preparation methods use mechanical stirring, homogenization, and other methods to prepare emulsions. Although the process conditions are simple, the preparation repeatability is very poor, and there are large differences in performance between different batches of products, which is not easy for industrial scale-up production. ...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/34A61K45/00A61K48/00C08J3/12
Inventor 马光辉卫强苏志国宋薇赖波
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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