Narcotic analgesic-loaded sustained-release microsphere and preparation method thereof and application thereof

A technology for sustained-release microspheres and analgesics, which is applied in anesthetics, pharmaceutical formulations, antipyretics, etc., can solve the problems of easy agglomeration and aggregation, difficulty in summarizing the release cycle, and high preparation costs, so as to ensure repeatability. , the effect of reducing drug escape and facilitating stability
CN109010307AActive Publication Date: 2018-12-18INST OF PROCESS ENG CHINESE ACAD OF SCI +2
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF PROCESS ENG CHINESE ACAD OF SCI
Publication Date
2018-12-18

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Abstract

The invention discloses a narcotic analgesic-loaded sustained-release microsphere and a preparation method thereof and application thereof. The narcotic analgesic-loaded sustained-release microspherecan be continuously released for 1 to 7 days, the burst release rate is less than 20% within 0.5 hour, and the drug embedding rate is higher than 80%, so that high drug embedding rate and low burst release rate and sustained release can be realized. The method has simple process, the obtained product has uniform particle size, batches of products have good repeatability, and the preparation methodis easy for industrial production.
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Description

technical field

[0001] The present invention relates to the technical field of sustained-release medicaments, and more particularly to a sustained-release microsphere loaded with narcotic and analgesic drugs, its preparation method and application. Background technique

[0002] As an innate feeling of the human body, pain plays an important role in avoiding injury and maintaining the endocrine environment of the human body. This is because when the body is stimulated or hurt, it can produce a defensive response, so that the body can avoid being hurt. On the other hand, pain such as neuralgia, cancer pain, low back pain, etc. not only bring suffering to patients, but also cause inconvenience in life, and also cause physiological dysfunction, and severe cases can lead to shock and death.

[0003] In clinical treatment, narcotic analgesics can be used not only for surgical anesthesia, but also for pain control and relief. However, the action time of anesthetic analgesics curre...

Claims

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