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Composition containing dicaffeoyl quinic acid and its preparing method

A technique of caffeoylquinic acid and composition, which is applied in the field of compositions containing dicaffeoylquinic acid and its preparation, and can solve problems such as inconvenience and inconvenience of patients

Inactive Publication Date: 2005-05-18
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary tablets or other solid preparations are taken by taking a large amount of solid preparations (such as tablets or capsules) with an appropriate amount of water every day, which not only brings some inconvenience to ordinary patients, but also brings inconvenience to children, the elderly and patients with dysphagia. great inconvenience

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1. dicaffeoylquinic acid suspension

[0023] 1,5-Di-O-caffeoylquinic acid 2.5g

[0024] Sucrose 4g

[0025] Microcrystalline Cellulose 4g

[0026] Sodium saccharin 0.1g

[0027]Citric acid 0.1g

[0028] Sodium citrate 0.2g

[0029] Vitamin C 0.2g

[0030] Sodium Benzoate 0.2g

[0031] Proper amount of vanillin

[0032] Xanthan gum 1g

[0033] water 100ml

[0034] Grind 1,5-di-O-caffeoylquinic acid, sucrose and microcrystalline cellulose together, pass through an 80-mesh sieve, and mix well. The remaining ingredients are dissolved in water to obtain a viscous mucilage liquid. Slowly add the glue liquid into the mixed powder above, grind while adding, and finally obtain a uniformly suspended dicaffeoylquinic acid suspension.

Embodiment 2

[0035] One of embodiment 2. dicaffeoylquinic acid solutions

[0036] 1,5-Di-O-caffeoylquinic acid 2g

[0037] Propylene glycol 20ml

[0038] Vitamin C 0.2g

[0039] Lactic acid 0.2g

[0040] Benzoic acid 0.1g

[0041] Aspartame 0.2g

[0042] water 50ml

[0043] Take 1,5-di-O-caffeoylquinic acid and propylene glycol, heat to dissolve, slowly drop into the stirred aqueous solution containing vitamin C, lactic acid, benzoic acid, and aspartame to obtain clear dicaffeoylquinic acid Niacin solution.

Embodiment 3

[0044] Embodiment 3. The second of dicaffeoylquinic acid solution

[0045] 3,5-Di-O-caffeoylquinic acid 2g

[0046] Macrogol 400 20ml

[0047] Vitamin C 0.1g

[0048] Lactic acid 0.1g

[0049] Sorbic acid 0.05g

[0050] Aspartame 0.1g

[0051] water 50ml

[0052] Take 3,5-di-O-caffeoylquinic acid and polyethylene glycol 400, heat to dissolve, slowly drop into the stirred aqueous solution containing vitamin C, lactic acid, sorbic acid, and aspartame to obtain a clear Dicaffeoylquinic acid solution.

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PUM

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Abstract

The present invention discloses composition containing dicaffeoyl quinic acid and its preparation process. The composition is suspension, gel or solution with or without dispersing medium. The composition is easy to take, acceptable, and especially suitable for long term taking and for children, aged people and people with dysphagia. The present invention also provides the preparation process of dicaffeoyl quinic acid solution.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a composition containing dicaffeoylquinic acid and a preparation method thereof. Background technique [0002] Dicaffeoylquinic acid (DCQA), also known as dicaffeoylquinic acid. It is the dicaffeic acid ester of quinic acid, depending on the caffeoyl substitution position, there can be 1,5-di-O-caffeoylquinic acid, 1,3-di-O-caffeoylquinic acid, 1, 4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, 3,4-di-O-caffeoylquinic acid, 4,5-di-O-caffeoylquinic acid Quinic acid, among which 1,5-di-O-caffeoylquinic acid has been reported more. The chemical name of 1,5-di-O-caffeoylquinic acid is (1s,1α,3β,4α,5α)1,3-bis[[3-(3,4-dihydroxyphenyl)-1- Oxo-2-propenyl]oxy]4,5-dihydroxy-cyclohexane acid, formula C 25 h 24 o 12 . As a pharmacological active ingredient, dicaffeoylquinic acid has a wide range of actions, and has antiviral (CN1087608; EP1008344; US6331565; US20020111382), antioxida...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/216A61P31/12A61P39/06
Inventor 金义光李淼董俊兴
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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