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Application of 5,6,4'-trihydroxyl flavone-7-O-beta-D-glucuronide methyl ester and medicinal composition as well as preparation thereof

A composition and drug technology, applied in the field of medicine, can solve problems such as less research and no literature reports

Active Publication Date: 2012-06-27
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, the pharmacological and clinical studies on scutellarin, another main active ingredient in the traditional Chinese medicine Erigeron breviscapine, are relatively in-depth. There are few studies on methyl ester, and there is no literature report on its application in improving human sleep and delaying aging.

Method used

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  • Application of 5,6,4'-trihydroxyl flavone-7-O-beta-D-glucuronide methyl ester and medicinal composition as well as preparation thereof
  • Application of 5,6,4'-trihydroxyl flavone-7-O-beta-D-glucuronide methyl ester and medicinal composition as well as preparation thereof
  • Application of 5,6,4'-trihydroxyl flavone-7-O-beta-D-glucuronide methyl ester and medicinal composition as well as preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 15

[0024] Example 15, 6,4'-trihydroxyflavone-7-O-β-D-glucuronide methyl ester experimental research on improving sleep

[0025] 1. Reagents, reagents and materials

[0026] 5,6,4′-Trihydroxyflavone-7-O-β-D-glucuronide methyl ester, provided by Kunming Pharmaceutical Group Co., Ltd. Drug Research Institute. Sodium pentobarbital was provided by Xi'an Woersen Biotechnology Co., Ltd.

[0027] Kunming mice, weighing 18-22g, 180, half male and half male, provided by the Animal Laboratory of Kunming Pharmaceutical Group Co., Ltd., production license number SCXK (Dian) 2005-0006, use license number SYXK (Dian) 2005 -0006.

[0028] 2. Test method

[0029] 2.1 Animal grouping and administration

[0030] The experimental animals are divided into 3 batches, which are respectively recorded as the experimental batch I (the impact on the body weight of mice, the direct sleep experiment, the experiment of prolonging the sleep time of pentobarbital sodium), and the experimental II batch (the ...

Embodiment 25

[0061] Example 25, 6,4'-trihydroxyflavone-7-O-β-D-glucuronide methyl ester on the effect of Drosophila lifespan experiment

[0062] 1. Reagents, reagents and materials

[0063] 5,6,4′-Trihydroxyflavone-7-O-β-D-glucuronide methyl ester, provided by Kunming Pharmaceutical Group Co., Ltd. Drug Research Institute.

[0064] American wild-type Drosophila melanogaster, breeding environment: temperature 25±1°C, relative humidity 60±5%, 12h light and 12h dark alternate culture, provided by Kunming Institute of Zoology.

[0065] 2. Test method

[0066] Collect the newly emerged Drosophila adults within 24 hours, anesthetize with ether, distinguish male and female individuals, weigh them separately, and divide them into 5 groups randomly: 1 control group and 4 groups containing different concentrations of 5,6,4′-trihydroxyflavone - Experimental group of methyl 7-O-β-D-glucuronate. There were 100 fruit flies in each group, half male and half female, respectively placed in 3 cm × 10 cm ...

Embodiment 35

[0072] Example 35, 6,4′-trihydroxyflavone-7-O-β-D-glucuronide methyl ester anti-aging mechanism experiment

[0073] 1. Reagents, reagents and materials

[0074] 5,6,4′-Trihydroxyflavone-7-O-β-D-glucuronide methyl ester, provided by Kunming Pharmaceutical Group Co., Ltd. Drug Research Institute.

[0075] Malondialdehyde (MDA) assay kit, batch number 20080925; superoxide dismutase (SOD) assay kit, stipulates that the amount of SOD corresponding to the SOD inhibition rate of 50% per milliliter of reaction solution is 1 nitrite Unit (NU), batch number 20080629; glutathione peroxidase (GSH-PX) assay kit, stipulates that every 4 μl of whole blood should be reacted at 37°C for 5 minutes, deducting the effect of non-enzymatic reactions, so that GSH in the reaction system A concentration decrease of 1 μmol / L is 1 enzyme activity unit, and the batch number is 20080918; the reactive oxygen species (ROS) assay kit stipulates that each milliliter of serum should be reacted at 37°C for 1 m...

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Abstract

The invention relates to the field of medicines, and discloses new application of 5,6,4'-trihydroxyl flavone-7-O-beta-D-glucuronide methyl ester to the field of pharmacy and a medicinal composition as well as a preparation thereof. The 5,6,4'-trihydroxyl flavone-7-O-beta-D-glucuronide methyl ester has the effects of improving sleep, such as prolonging sleep time, improving sleep incidence rate, shortening sleep latency and delaying aging, and can be used for preparing medicaments or health-care products for improving sleep and delaying aging.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the new application of scutellarin methyl ester, namely 5,6,4'-trihydroxyflavone-7-O-β-D-glucuronide methyl ester, in the field of pharmacy. Background technique [0002] Human aging refers to a series of degenerative changes in morphological structure and physiological function with the growth of age after the human body grows and develops to maturity. It is a process of decline and decline in the functions of human tissues and organs. Modern medicine believes that aging is a comprehensive manifestation of various biochemical reactions in the body. Free radicals are always produced in the human body, but at the same time, there are effective free radical scavenging systems such as glutathione (GSH) and superoxide dismutase (SOD). Level. But with age, this balance is gradually disrupted, resulting in an excess of free radicals. Free radicals have a strong reaction ability, which can ox...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P25/20A61P39/06A23L1/30
Inventor 周荣光
Owner KPC PHARM INC
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