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A drug that speeds up brain recovery after anesthesia and improves brain cognitive function through the nose through the olfactory pathway

A technology for improving cognition and smell, applied in the fields of medicine, health care, aromatherapy, and essential oil efficacy, which can solve the problems of slow drug elimination, slow metabolism of anesthetics, and delayed awakening.

Inactive Publication Date: 2011-12-21
ANHUI FENGLE PERFUME
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most anesthetics can cause hemodynamic changes, such as decreased cardiac output and blood pressure. In addition, intraoperative blood loss and fluid imbalance may induce hypotension, resulting in an imbalance in the body's oxygen supply and delayed recovery, especially for elderly patients. Poor tolerance to hypoxia, a common cause of delayed emergence
Hypothermic anesthesia can reduce the elimination speed of drugs in the body, slow the metabolism of anesthetic drugs and increase the accumulation in the body, and prolong the residual action time of anesthetic drugs, which leads to a delay in recovery after anesthesia.
[0004] There are serious side effects of many resuscitative drugs in clinical use

Method used

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  • A drug that speeds up brain recovery after anesthesia and improves brain cognitive function through the nose through the olfactory pathway
  • A drug that speeds up brain recovery after anesthesia and improves brain cognitive function through the nose through the olfactory pathway
  • A drug that speeds up brain recovery after anesthesia and improves brain cognitive function through the nose through the olfactory pathway

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] Experimental study on the awakening effect of aromatic essential oils on animals under general anesthesia

[0023] Materials and methods

[0024] 1. Animals and medicines

[0025] In this study, male 3-4 month-old Sprague Dawley (SD) rats (250-320 g) were purchased from Animal Center of Anhui Province. Caged animals (6 per cage) had at least one week to acclimatize in a ventilated room with constant temperature (22-25°C) and humidity, with free access to food and water. The ventilation room has a 12-hour day and night cycle, alternating at 7:00 am. All experiments minimized the damage to animals and reduced the number of animals used throughout the experiments to ensure effective experiments. Sodium pentobarbital was purchased from Sigma-Aldrich and dissolved in sterile saline (0.9% NaCl, w / v). Propofol emulsion and ketamine were donated to the Anesthesiology Department of the First Affiliated Hospital of Anhui Medical University. Peppermint essential oil, rosemary ...

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Abstract

The invention discloses a medicine for accelerating brain recovery after anesthesia and improving cognition through the nose through the olfactory pathway. Mixture, which can also add other natural spices and native plant essential oils such as lemon essential oil, rosemary essential oil, clove essential oil and neroli essential oil, etc. The medicine, aromatic smell substance or plant essential oil of the present invention stimulates the olfactory nerve through the nose or mouth, regulates the olfactory center of the brain through the olfactory pathway and then affects the secondary olfactory center, so as to refresh the brain, improve the cognitive function of the brain and improve the brain function; moreover These important natural aromatic substances or essential oils directly regulate the instinctive olfactory nerves and play a regulatory role through specific olfactory receptors without any side effects.

Description

technical field [0001] The invention belongs to the fields of medical health care, aromatherapy and essential oil efficacy, and specifically relates to a medicine for accelerating brain recovery after anesthesia and improving brain cognitive function through the nose through the olfactory pathway. Background technique [0002] Anesthesia is a high-risk technology. Anesthesia safety is always the top priority of the anesthesiology department. There are many accidents and complications during anesthesia, such as cardiac arrest, arrhythmia, acute pulmonary edema, and acute respiratory failure. Therefore, how to wake up as soon as possible after anesthesia is over is a medical problem. [0003] Delayed recovery after anesthesia and drug overdose or residual effects. For example, due to liver and kidney dysfunction, the drug cannot be degraded and excreted normally, causing the drug to accumulate in the body; or due to high sensitivity to anesthetics, or poor drug tolerance can l...

Claims

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Application Information

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IPC IPC(8): A61K36/534A61K36/185A61K35/55A61K35/413A61K36/9064A61K36/752A61K36/73A61K36/61A61K36/57A61K36/535A61K36/532A61K36/53A61K36/324A61K36/23A61K31/22A61K31/045A61K31/122A61P25/28A61P25/00
Inventor 李光武陈东晨方文恒徐金勇吴永虎郑俊峰柳小平汤文王广强
Owner ANHUI FENGLE PERFUME
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