Calf feed additive and preparation method thereof

Abstract

The invention discloses a calf feed additive and a preparation method thereof. The feed additive is prepared from the following components: 100 parts of Chinese herbal medicine fermentation liquor, 10-30 parts of modified hydrogel, 8-16 parts of alfalfa meal, 5-10 parts of calcium hydrogen phosphate, 5-10 parts of whey powder, 1-3 parts of choline chloride, 0.5-2 parts of table salt and 0.1-1 part of baking soda. The Chinese herbal medicine fermentation liquor is prepared by fermenting a Chinese herbal medicine extracting solution with a complex microbial inoculant, and the modified hydrogel is prepared by crosslinking lipoic acid modified bentonite and fumaric acid modified sodium alginate under photo-initiation; the prepared feed additive is good in palatability, the feed intake of the calves can be remarkably increased, meanwhile, the gastrointestinal digestion function of the calves is enhanced, the digestion, conversion and utilization rate of the feed is increased, and rapid growth of the calves is promoted.

Description

Technical Field

[0001] The invention relates to the technical field of feed additives, and in particular to a calf feed additive and a preparation method thereof. Background Art

[0002] After weaning, the content of metabolites in calves will change significantly, leading to anorexia, growth retardation, and decreased immunity. These phenomena not only increase the morbidity and mortality of calves, affecting their healthy growth, but also have adverse effects on subsequent production performance, causing huge economic losses to the cattle industry. Therefore, how to provide scientific and reasonable nutritional support for calves after weaning has become an important issue that needs to be urgently addressed in the current animal husbandry industry.

[0003] Cattle farms usually add antibiotics to feed to reduce the incidence of animal diarrhea, promote animal growth, and improve feed utilization. For example, Chinese patent document CN101574113B discloses a calf starter feed, which consists of steam-flaked corn, pellets and other components (including mildew inhibitors, preservatives, antibiotics and molasses). This starter feed has the advantages of strong palatability and large feed intake, which is conducive to the digestion and absorption of calves and promotes their healthy growth. However, the large-scale use of veterinary antibiotics in recent years has led to the production of antibiotic-resistant bacteria in animals, reducing the effectiveness of antibiotic use, and the problem of antibiotic residues has aroused widespread concern, limiting its application in feed.

[0004] Another alternative is to use a Chinese medicine composition to promote the growth of beef cattle. Chinese patent document CN109123124B provides a composition containing a variety of Chinese medicines such as Codonopsis pilosula, Citrus aurantium, Citrus aurantium, Angelica dahurica, Cinnamomum cassia, Dioscorea opposita, Scutellaria baicalensis, Alisma orientalis, Citron, Nepeta tenuifolia, Saposhnikovia divaricata, Poria cocos and Rhubarb, and applies it to feed. The Chinese medicine composition can effectively promote the growth of beef cattle, but because Chinese herbal medicines themselves have a strong odor, feeds with Chinese herbal medicines often cause cattle to be unwilling to eat, affecting the actual application effect of the feed.

[0005] In summary, although existing calf feed additives have achieved certain results in meeting nutritional needs, improving feed utilization and promoting healthy growth of calves, they still have the following main problems:

[0006] 1. Antibiotic resistance problem: Long-term and excessive use of antibiotics can easily lead to the emergence of drug-resistant bacteria, which not only reduces the efficacy of antibiotics but also may bring risks of drug residues and environmental pollution.

[0007] 2. Chinese herbal medicines have poor palatability: Although Chinese herbal medicine additives have the advantages of being natural and multifunctional, their strong smell and taste will affect the calves' feed intake, limiting their application effect.

[0008] 3. Single nutritional composition: Some additives only supplement specific nutrients, lack systematicity, and cannot fully meet the diverse nutritional needs of calves at different growth stages.

[0009] Therefore, it is urgent to develop a new type of calf feed additive that is safe, has no residue, has no toxic side effects, avoids drug resistance, and can significantly increase calf feed intake and feed utilization. In addition, the preparation method of the additive should be simple and efficient, reduce production costs, and meet the needs of the modern cattle industry for efficient and environmentally friendly feed additives.

[0010] The present invention provides a novel calf feed additive and a preparation method thereof, which optimizes the formula structure, selects a variety of natural effective ingredients, improves the nutritional comprehensiveness and bioavailability of the feed, improves the preparation process, reduces the production cost, overcomes the deficiencies in the prior art, can effectively promote the healthy growth of calves, and has broad application prospects and significant economic value. Summary of the invention

[0011] In order to solve the deficiencies of the prior art, the purpose of the present invention is to provide a calf feed additive and a preparation method thereof. The feed additive has good palatability, can significantly increase the feed intake of calves, while enhancing the gastrointestinal digestive function of calves, improving the digestion and conversion utilization rate of feed, and promoting rapid growth of calves.

[0012] In order to achieve the above object, the present invention adopts the following technical solution:

[0013] A calf feed additive is prepared from the following components by weight: 100 parts of Chinese herbal medicine fermentation liquid, 10-30 parts of modified hydrogel, 8-16 parts of alfalfa powder, 5-10 parts of calcium hydrogen phosphate, 5-10 parts of whey powder, 1-3 parts of choline chloride, 0.5-2 parts of salt and 0.1-1 part of baking soda.

[0014] Preferably, the preparation method is made of the following components, measured by weight: 100 parts of Chinese herbal fermentation liquid, 20 parts of modified hydrogel, 12 parts of alfalfa powder, 8 parts of calcium hydrogen phosphate, 8 parts of whey powder, 2 parts of choline chloride, 1 part of salt, and 0.5 parts of baking soda.

[0015] Preferably, the calf feed additive is added in an amount of 0.2-1 wt % in the calf basic diet.

[0016] Preferably, the method for preparing the Chinese herbal fermentation liquid comprises the following steps: weighing the Chinese herbal raw materials by weight, drying and crushing to obtain Chinese herbal powder; adding the Chinese herbal powder into water and steaming, filtering to obtain the Chinese herbal extract; cooling to room temperature, and then adding a composite bacterial agent and molasses for fermentation, and obtaining the Chinese herbal fermentation liquid after the fermentation is completed.

[0017] Preferably, the Chinese herbal raw materials, measured by weight, are: 40-60 parts of astragalus, 40-60 parts of gynostemma pentaphyllum, 40-60 parts of radish seeds, 40-60 parts of patchouli, 30-50 parts of lophatherum gracile, 20-40 parts of atractylodes, 20-40 parts of cornus officinalis, 20-40 parts of hawthorn, 20-40 parts of tangerine peel, and 10-20 parts of licorice.

[0018] Preferably, the Chinese herbal raw materials, measured by weight, are: 50 parts of astragalus, 50 parts of gynostemma pentaphyllum, 50 parts of radish seeds, 50 parts of patchouli, 40 parts of lophatherum gracile, 30 parts of atractylodes, 30 parts of cornus officinalis, 30 parts of hawthorn, 30 parts of tangerine peel, and 15 parts of licorice.

[0019] Preferably, the drying is carried out at 50-70° C. and the powder is crushed to 20-50 mesh; the dosage ratio of the Chinese herbal medicine powder to water is 1 g: 8-10 mL; and the cooking conditions are boiling over high heat and keeping warm over low heat for 30-90 min.

[0020] Preferably, the composite bacterial agent is obtained by mixing Lactobacillus rhamnosus, Lactobacillus acidophilus, yeast, and Bifidobacterium animalis in a weight ratio of 1:2-3:2-3:1-2; the weight ratio of Chinese herbal medicine extract: molasses: composite bacterial agent is 400:60-80:30-50; and the fermentation conditions are anaerobic fermentation at 35-40°C for 36-48h.

[0021] Preferably, the composite bacterial agent is obtained by mixing Lactobacillus rhamnosus, Lactobacillus acidophilus, yeast, and Bifidobacterium animalis in a weight ratio of 1:3:3:2.

[0022] Preferably, the composite bacterial agent is obtained by mixing Lactobacillus rhamnosus, Lactobacillus acidophilus, yeast, and Bifidobacterium animalis in a weight ratio of 1:2:2:1.

[0023] Preferably, the fermentation condition is anaerobic fermentation at 38°C for 42 hours.

[0024] Preferably, the method for preparing the modified hydrogel comprises the following steps:

[0025] (1) drying bentonite, adding it to ethanol, then adding a solid acid catalyst and thioctic acid, stirring for activation, adjusting the pH, stirring for reaction, centrifuging the product, washing with alcohol, and drying it to obtain pretreated bentonite;

[0026] Preparation of pretreated bentonite: First, the bentonite is dried to remove moisture and impurities. Then, the bentonite is dispersed in ethanol, and solid acid catalyst and lipoic acid are added to activate the carboxyl groups on its surface. This activation process promotes the esterification grafting reaction between bentonite and lipoic acid to form an ester bond, thereby improving the organic compatibility and functional properties of the bentonite. After separation and drying, the pretreated bentonite is obtained, which provides a good substrate for subsequent composites.

[0027] Preferably, in step (1), the ratio of bentonite, solid acid catalyst and thioctic acid is 10g:0.1-2g:3-6g; the stirring activation condition is stirring activation at 60-80°C for 2-5h; the pH is adjusted to 2-4 with dilute acid; and the stirring reaction condition is stirring reaction at 60-80°C for 6-10h.

[0028] (2) dissolving sodium alginate in an ethanol solution, stirring evenly, adding fumaric acid and a solid acid catalyst, stirring to react, filtering the product, dialyzing to remove unreacted substances, and freeze-drying to obtain modified sodium alginate;

[0029] Preparation of modified sodium alginate: Next, sodium alginate is dissolved in a water-ethanol mixed solvent, and fumaric acid and a solid acid catalyst are added to promote the esterification reaction. Under the action of the solid acid catalyst, the carboxyl group of fumaric acid reacts with the hydroxyl group of sodium alginate to successfully introduce carbon-carbon double bonds into the sodium alginate molecular chain. These double bonds not only enhance the structural stability of sodium alginate by increasing the rigidity of the molecular chain and providing additional cross-linking sites, but also provide reaction sites for subsequent photoinduced cross-linking, thereby increasing the cross-linking density and mechanical strength of the final hydrogel. After the reaction is completed, the modified sodium alginate containing double bonds is obtained by filtration and freeze-drying.

[0030] Preferably, in step (2), the concentration of the ethanol solution is 30-70 wt %; the ratio of sodium alginate, fumaric acid and solid acid catalyst is 5-10 g: 0.5-4 g: 0.1-2 g; and the stirring reaction conditions are 60-80° C. and 6-10 h.

[0031] (3) Pretreated bentonite and modified sodium alginate are dispersed in an ethanol solution, stirred evenly, phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt is added, gradient freezing treatment is performed, the frozen solution is irradiated under ultraviolet light, the product is mechanically crushed, freeze-dried, and ground to obtain a modified hydrogel.

[0032] Preparation of modified hydrogel: Finally, the pretreated bentonite and modified sodium alginate are evenly dispersed in a water-ethanol mixed solvent, and a gradient freezing treatment is performed after adding the photoinitiator LAP to form a freeze-thaw structure. This freeze-thaw process produces physical crosslinking points, which enhances the structural stability of the hydrogel. Subsequently, LAP is activated by ultraviolet light or blue light to generate free radicals, which trigger the covalent crosslinking reaction between the disulfide bonds on the surface of bentonite and the double bonds on the modified sodium alginate, thereby constructing a stable three-dimensional network structure. Finally, micron-sized microgel powder is obtained by mechanical crushing and grinding to complete the preparation of the modified hydrogel.

[0033] Preferably, in step (3), the concentration of the ethanol solution is 30-70wt%; the dosage ratio of the pretreated bentonite, modified sodium alginate, and phenyl (2,4,6-trimethylbenzoyl) lithium phosphate is 10g: 5-10g: 0.1-2g; the gradient freezing treatment is gradient freezing at -5 to -80°C for 0.5 to 48h; ultraviolet light irradiation is 1 to 30min; and the product is ground into 1 to 1000μm.

[0034] Specifically, the product can be ground to 1, 5, 10, 50, 100, 150, 200, 250, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000 μm.

[0035] The present invention also claims protection for a method for preparing the calf feed additive, comprising the following steps: adding calcium hydrogen phosphate, choline chloride, salt, and baking soda to the Chinese herbal fermentation liquid, stirring evenly, adding half of the modified hydrogel, adding alfalfa powder and whey powder while stirring, and then adding the remaining half of the modified hydrogel, stirring evenly, drying and crushing at room temperature, and passing through an 80-120 mesh sieve to obtain the calf feed additive.

[0036] Compared with the prior art, the present invention has the following beneficial effects:

[0037] 1) The present invention provides a calf feed additive, which combines a variety of natural effective ingredients to significantly increase the feed intake and feed conversion rate of calves and promote their healthy growth. The feed additive contains a variety of Chinese herbal medicines, which play the effects of invigorating qi and strengthening the spleen, digesting food and eliminating accumulation, clearing away heat and purging fire, and stimulating appetite and widening the intestines. Alfalfa meal has an aromatic smell and good taste. It is rich in high-quality crude fiber, protein, essential amino acids, vitamins and minerals. It can enhance the palatability of feed, promote digestive health, and support the healthy development of the rumen. Calcium hydrogen phosphate provides two key minerals, calcium and phosphorus, to support the development of bones and teeth, participate in energy metabolism and physiological functions, and prevent growth retardation and bone deformities caused by deficiency. Whey powder is rich in high-quality protein and lactose, which is easy to digest and absorb, improves the palatability of feed, provides energy, and promotes intestinal health. Choline chloride promotes fat metabolism, supports the development of the nervous system, improves feed utilization, participates in biochemical reactions as a methyl donor, and contributes to the rapid growth of calves. Table salt provides sodium and chloride ions, maintains electrolyte balance, stimulates appetite, promotes the secretion of saliva and digestive juices, and enhances nutrient absorption. Baking soda acts as a rumen buffer to maintain a suitable pH value in the rumen, prevent acidosis, promote the fermentation of beneficial microorganisms, and improve feed efficiency. Modified hydrogel as a carrier not only improves the smell and taste of Chinese herbal medicine, but also promotes the growth of probiotics, optimizes the intestinal flora structure of calves, and enhances their immunity and metabolic absorption capacity. The overall formula is natural and safe, avoiding the drug resistance problems and environmental pollution risks brought by traditional antibiotics, meeting the needs of modern cattle farming for efficient and environmentally friendly feed additives, and has broad application prospects and significant economic benefits.

[0038] 2) The present invention provides a calf feed additive, in which each Chinese herbal medicine plays its own unique effect in the feed additive, and the synergistic effect significantly improves the health and growth performance of the calf. Astragalus has the effects of invigorating qi and strengthening the exterior, supporting toxins and draining pus, and astringing sores and promoting muscle growth, which can enhance the immunity of the calf and help it resist the invasion of external pathogens; Cornus officinalis supports the growth and development of the calf and maintains the stability of physiological functions by nourishing the liver and kidneys, astringing and consolidating. The combination of radish seeds and hawthorn can effectively help digestion and dissipate bloating, reduce gastrointestinal burden, promote the digestion and absorption of feed, and has the effects of descending qi and resolving phlegm, dispersing blood stasis and promoting stagnation, helping the calf maintain a good digestive system health. Light bamboo leaves and Patchouli jointly play the role of removing dampness and invigorating the spleen, clearing heat and purging fire, eliminating restlessness and quenching thirst, promoting diuresis and relieving stranguria, improving the digestive system and metabolic function of the calf, reducing moisture accumulation, and improving the overall health level. Tangerine peel and Atractylodes lancea further enhance the digestive ability and resistance of the calf by regulating qi and strengthening the spleen, dispelling wind and cold, and drying dampness and resolving phlegm, ensuring that it can efficiently absorb nutrients. Gynostemma pentaphyllum has the effects of enhancing the activity of lymphocytes in the blood, improving immune function, and having sedation and anti-stress, helping calves to maintain a stable physiological state in the face of environmental changes and stressors. Licorice not only tonifies the spleen and replenishes qi, eliminates phlegm and relieves cough, but also has the functions of harmonizing the middle and relieving urgency and coordinating various medicines, ensuring that each component can coexist harmoniously in the formula, enhancing the palatability of feed, and improving the feeding willingness of calves. In short, the feed additive of the present invention gives full play to its respective pharmacological effects by accurately combining a variety of Chinese herbal medicines, comprehensively improving the appetite, digestion and absorption capacity, immunity and overall health level of calves, thereby achieving rapid and healthy growth and development, and has significant economic benefits and application value.

[0039] 3) The present invention provides a Chinese herbal medicine fermentation liquid, which is decomposed by microorganisms, and the fermentation process effectively releases the active ingredients in the Chinese herbal medicine, such as organic acids and polysaccharides, which help to improve the metabolic absorption capacity of calves. During the fermentation process, the complex plant components are decomposed by microorganisms into small molecules that are easier for calves to digest and absorb, reducing the anti-nutritional factors originally present in the Chinese herbal medicine, thereby improving the nutritional value and bioavailability of the feed. In addition, fermentation significantly improves the palatability of Chinese herbal medicine. Chinese herbal medicine usually has a heavy smell and bitter taste, which is not conducive to the animal's desire to eat. Through fermentation, the bitter and astringent components are effectively masked, and the generated organic acids not only reduce the pH value of the feed, but also give the feed a milder taste, which enhances the calf's enthusiasm for eating. The organic acids and polysaccharides produced during the fermentation process also have the effect of promoting intestinal health. These substances can act as prebiotics, support the growth of beneficial bacteria, inhibit the reproduction of harmful bacteria, optimize the intestinal microecological environment of calves, and enhance their immunity and disease resistance. In addition, the content of enzymes and vitamins in the fermentation products has increased, which helps to improve the digestive function and overall health of calves. In general, the Chinese herbal fermentation process not only improves the nutritional value and palatability of the feed, but also comprehensively promotes the healthy growth and efficient feed utilization of calves by improving intestinal flora and enhancing immune function, further enhancing the economic benefits and application prospects of the feed additive of the present invention.

[0040] 4) The present invention provides a method for preparing a modified hydrogel. First, lipoic acid is pretreated with a solid acid catalyst to activate its surface carboxyl group and graft bentonite to enhance the organic compatibility and functional properties of bentonite. Secondly, sodium alginate and fumaric acid are reacted in a water-ethanol mixed solvent, and a carbon-carbon double bond is introduced under the action of a solid acid catalyst to form a modified sodium alginate with a high cross-linking site. Finally, the pretreated bentonite and the modified sodium alginate are subjected to free radical cross-linking by gradient freezing and ultraviolet irradiation under the action of a photoinitiator to construct a stable three-dimensional network structure, and finally a micron-sized modified hydrogel powder is obtained. The entire preparation process uses green solvents and environmentally friendly processes, which not only reduces production costs, but also improves the sustainability of the process, meeting modern environmental protection requirements.

[0041] 5) The present invention provides a modified hydrogel, which has a high cross-linking density and a stable three-dimensional network structure, and can effectively wrap and protect the active ingredients in Chinese herbal medicines to prevent them from being inactivated or degraded due to external factors such as high temperature and humidity during feed processing and storage. This protection mechanism ensures that the active ingredients can be stably released in the calf's digestive tract, prolongs its action time, and improves its bioavailability. Secondly, the modified hydrogel has excellent sustained-release properties, which can achieve the gradual release of nutrients and avoid the excessive burden on the calf's stomach and intestines caused by a one-time large-scale release. By regulating the swelling behavior and degradation rate of the hydrogel, the protein, vitamins and other nutrients in the feed can be slowly supplied to meet the continuous nutritional needs of the calf, promote its healthy growth and efficient metabolism. In addition, the porous structure of the modified hydrogel increases the surface area of ​​the feed, improves the uniform distribution of the feed, and ensures that each bite of feed contains various nutrients and Chinese herbal essences in a balanced manner. This not only improves the taste and palatability of the feed, increases the calf's interest in eating, but also effectively reduces feed waste and improves feed utilization and conversion efficiency. The modified hydrogel also has the function of regulating the intestinal environment. It can promote the growth of beneficial bacteria, inhibit the reproduction of harmful bacteria, and optimize the intestinal microecological balance of calves. A good intestinal environment not only enhances the immunity and disease resistance of calves, but also improves the absorption efficiency of nutrients, promotes overall health and growth performance. In short, the modified hydrogel, through its unique physicochemical properties and biological functions, not only improves the stability and nutritional value of feed additives, but also optimizes the feeding behavior and intestinal health of calves, and comprehensively promotes the efficient growth and healthy development of calves. DETAILED DESCRIPTION

[0042] In order to make the purpose, technical solution and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with embodiments. Of course, the specific embodiments described here are only used to explain the present invention and are not used to limit the present invention.

[0043] Unless otherwise specified, the chemical reagents and materials in the present invention are purchased from commercial sources or synthesized from raw materials purchased from commercial sources.

[0044] Bentonite was purchased from Lingshou County Zhongyan Building Materials Factory, mesh size 200;

[0045] All Chinese herbal medicines were purchased from China National Pharmaceutical Group Pharmacy.

[0046] A method for preparing a calf feed additive comprises the following steps:

[0047] (1) Weigh 40-60 parts of Astragalus, 40-60 parts of Gynostemma, 40-60 parts of Radish Seed, 40-60 parts of Patchouli, 30-50 parts of Lophatherum gracile, 20-40 parts of Atractylodes, 20-40 parts of Cornus officinalis, 20-40 parts of Hawthorn, 20-40 parts of Tangerine Peel, and 10-20 parts of Licorice, dry at 50-70°C, and grind to 20-50 mesh to obtain Chinese herbal medicine powder; add the Chinese herbal medicine powder to water (the ratio of Chinese herbal medicine powder to water is 1 g: 8-10 g). 10mL), boil over high heat, keep warm over low heat for 30-90min, filter to obtain Chinese herbal medicine extract; cool 400g of Chinese herbal medicine extract to room temperature, then add 60-80g of composite bacterial agent (Lactobacillus rhamnosus, Lactobacillus acidophilus, yeast, and Bifidobacterium animalis mixed in a weight ratio of 1:2-3:2-3:1-2) and 30-50g of molasses, and perform anaerobically fermentation at 35-40°C for 36-48h, and obtain Chinese herbal medicine fermentation liquid after the fermentation is completed;

[0048] (2) 10 g of bentonite is dried and added to 100-200 mL of ethanol, and then 0.1-2 g of a solid acid catalyst and 3-6 g of lipoic acid are added, and the mixture is activated by stirring at 60-80° C. for 2-5 h, and the pH is adjusted to 2-4 with a dilute acid, and the mixture is reacted by stirring at 60-80° C. for 6-10 h, and the product is centrifuged, washed with alcohol, and dried to obtain pretreated bentonite;

[0049] (3) dissolving 5-10 g of sodium alginate in 100-200 mL of 30-70 wt% ethanol solution, stirring evenly, adding 0.5-4 g of fumaric acid and 0.1-2 g of solid acid catalyst, stirring and reacting at 60-80° C. for 6-10 h, filtering the product, dialyzing to remove unreacted products, and freeze-drying to obtain modified sodium alginate;

[0050] (4) dispersing 10 g of pretreated bentonite and 5-10 g of modified sodium alginate into 100-200 mL of 30-70 wt% ethanol solution, stirring evenly, adding 0.1-2 g of phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt, gradient freezing at -5 to -80 ° C for 0.5 to 48 h, placing the frozen solution under ultraviolet light for 1 to 30 min, mechanically crushing, freeze-drying, and grinding the product into 1 to 1000 μm to obtain a modified hydrogel;

[0051] (5) Add 5 to 10 parts of calcium hydrogen phosphate, 1 to 3 parts of choline chloride, 0.5 to 2 parts of salt, and 0.1 to 1 part of baking soda to 100 parts of Chinese herbal fermentation liquid, stir evenly, then add half of the modified hydrogel, add 8 to 16 parts of alfalfa powder and 5 to 10 parts of whey powder while stirring, and then add the remaining half of the modified hydrogel, stir evenly, dry and crush at room temperature, and pass through an 80-120 mesh sieve to obtain the calf feed additive.

[0052] The present invention will be further described below through specific embodiments.

[0053] Example 1

[0054] A method for preparing a calf feed additive comprises the following steps:

[0055] (1) Weigh 50 g of Astragalus, 50 g of Gynostemma pentaphyllum, 50 g of Radish Seed, 50 g of Patchouli, 40 g of Lophatherum gracile, 30 g of Atractylodes lancea, 30 g of Cornus officinalis, 30 g of Hawthorn, 30 g of Tangerine peel, and 15 g of Licorice, dry at 60° C., and crush to 40 mesh to obtain Chinese herbal medicine powder; add the Chinese herbal medicine powder to water (the ratio of Chinese herbal medicine powder to water is 1 g: 10 mL), boil over high heat, keep warm over low heat for 60 min, and filter to obtain a Chinese herbal medicine extract; cool 400 g of the Chinese herbal medicine extract to room temperature, then add 70 g of a composite bacterial agent (Lactobacillus rhamnosus, Lactobacillus acidophilus, yeast, and Bifidobacterium animalis mixed in a weight ratio of 1:2.5:2.5:1.5) and 40 g of molasses, and perform anaerobically fermentation at 38° C. for 42 h. After the fermentation is completed, a Chinese herbal medicine fermentation liquid is obtained;

[0056] (2) 10 g of bentonite was dried and added to 200 mL of ethanol, and then 2 g of silica gel-loaded phosphoric acid and 6 g of lipoic acid were added, and the mixture was stirred and activated at 80° C. for 2 h, and the pH was adjusted to 4 with dilute hydrochloric acid, and the mixture was stirred and reacted at 80° C. for 6 h. The product was centrifuged, washed with alcohol, and dried to obtain pretreated bentonite;

[0057] (3) Dissolve 10 g of sodium alginate in 200 mL of 50 wt% ethanol solution, stir evenly, add 4 g of fumaric acid and 2 g of silica gel-supported phosphoric acid, stir and react at 80° C. for 6 h, filter the product, dialyze to remove unreacted products, and freeze-dry to obtain modified sodium alginate;

[0058] (4) Dispersing 10 g of pretreated bentonite and 10 g of modified sodium alginate into 200 mL of 50 wt% ethanol solution, stirring evenly, adding 2 g of phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt, and gradient freezing at -80 ° C for 1 h. The frozen solution was placed under ultraviolet light for 30 min. The product was mechanically crushed, freeze-dried, and ground into 500 μm to obtain a modified hydrogel;

[0059] (5) Add 100 g of calcium hydrogen phosphate, 30 g of choline chloride, 20 g of salt, and 10 g of baking soda to 1000 g of Chinese herbal medicine fermentation liquid, stir well, add 150 g of modified hydrogel, add 160 g of alfalfa powder and 100 g of whey powder while stirring, and then add 150 g of modified hydrogel, stir well, dry and crush at room temperature, and pass through a 100-mesh sieve to obtain the calf feed additive.

[0060] Example 2

[0061] A method for preparing a calf feed additive comprises the following steps:

[0062] (1) Weigh 50 g of Astragalus, 50 g of Gynostemma pentaphyllum, 50 g of Radish Seed, 50 g of Patchouli, 40 g of Lophatherum gracile, 30 g of Atractylodes lancea, 30 g of Cornus officinalis, 30 g of Hawthorn, 30 g of Tangerine peel, and 15 g of Licorice, dry at 60° C., and crush to 40 mesh to obtain Chinese herbal medicine powder; add the Chinese herbal medicine powder to water (the ratio of Chinese herbal medicine powder to water is 1 g: 10 mL), boil over high heat, keep warm over low heat for 60 min, and filter to obtain a Chinese herbal medicine extract; cool 400 g of the Chinese herbal medicine extract to room temperature, then add 70 g of a composite bacterial agent (Lactobacillus rhamnosus, Lactobacillus acidophilus, yeast, and Bifidobacterium animalis mixed in a weight ratio of 1:2.5:2.5:1.5) and 40 g of molasses, and perform anaerobically fermentation at 38° C. for 42 h. After the fermentation is completed, a Chinese herbal medicine fermentation liquid is obtained;

[0063] (2) 10 g of bentonite was dried and added to 200 mL of ethanol, and then 1.5 g of silica gel-loaded phosphoric acid and 5 g of lipoic acid were added, and the mixture was stirred and activated at 75° C. for 3 h, and the pH was adjusted to 3 with dilute hydrochloric acid, and the reaction was stirred at 75° C. for 9 h. The product was centrifuged, washed with alcohol, and dried to obtain pretreated bentonite;

[0064] (3) 8 g of sodium alginate was dissolved in 200 mL of 50 wt% ethanol solution, stirred evenly, 3 g of fumaric acid and 1.5 g of silica gel-supported phosphoric acid were added, stirred and reacted at 75° C. for 8 h, the product was filtered, dialyzed to remove unreacted products, and freeze-dried to obtain modified sodium alginate;

[0065] (4) Dispersing 10 g of pretreated bentonite and 8 g of modified sodium alginate into 200 mL of 50 wt% ethanol solution, stirring evenly, adding 1.5 g of phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt, and freezing at -55 ° C for 24 h, irradiating the frozen solution under ultraviolet light for 20 min, mechanically crushing, freeze-drying, and grinding the product into 500 μm to obtain a modified hydrogel;

[0066] (5) Add 80 g of calcium hydrogen phosphate, 20 g of choline chloride, 15 g of salt, and 8 g of baking soda to 1000 g of Chinese herbal medicine fermentation liquid, stir evenly, add 120 g of modified hydrogel, add 120 g of alfalfa powder and 80 g of whey powder while stirring, and then add 120 g of modified hydrogel, stir evenly, dry and crush at room temperature, and pass through a 100-mesh sieve to obtain the calf feed additive.

[0067] Example 3

[0068] A method for preparing a calf feed additive comprises the following steps:

[0069] (1) Weigh 50 g of Astragalus, 50 g of Gynostemma pentaphyllum, 50 g of Radish Seed, 50 g of Patchouli, 40 g of Lophatherum gracile, 30 g of Atractylodes lancea, 30 g of Cornus officinalis, 30 g of Hawthorn, 30 g of Tangerine peel, and 15 g of Licorice, dry at 60° C., and crush to 40 mesh to obtain Chinese herbal medicine powder; add the Chinese herbal medicine powder to water (the ratio of Chinese herbal medicine powder to water is 1 g: 10 mL), boil over high heat, keep warm over low heat for 60 min, and filter to obtain a Chinese herbal medicine extract; cool 400 g of the Chinese herbal medicine extract to room temperature, then add 70 g of a composite bacterial agent (Lactobacillus rhamnosus, Lactobacillus acidophilus, yeast, and Bifidobacterium animalis mixed in a weight ratio of 1:2.5:2.5:1.5) and 40 g of molasses, and perform anaerobically fermentation at 38° C. for 42 h. After the fermentation is completed, a Chinese herbal medicine fermentation liquid is obtained;

[0070] (2) 10 g of bentonite was dried and added to 200 mL of ethanol, and then 1 g of silica gel-loaded phosphoric acid and 4 g of lipoic acid were added, and the mixture was stirred and activated at 70° C. for 4 h, and the pH was adjusted to 3 with dilute hydrochloric acid, and the mixture was stirred and reacted at 70° C. for 8 h. The product was centrifuged, washed with alcohol, and dried to obtain pretreated bentonite;

[0071] (3) 7 g of sodium alginate was dissolved in 200 mL of 50 wt% ethanol solution, stirred evenly, 2 g of fumaric acid and 1 g of silica gel-supported phosphoric acid were added, and the mixture was stirred and reacted at 70° C. for 7 h. The product was filtered, dialyzed to remove unreacted products, and freeze-dried to obtain modified sodium alginate;

[0072] (4) Dispersing 10 g of pretreated bentonite and 7 g of modified sodium alginate into 200 mL of 50 wt% ethanol solution, stirring evenly, adding 1 g of phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt, and gradient freezing at -30 ° C for 36 h. The frozen solution was placed under ultraviolet light for 10 min, and the product was mechanically crushed, freeze-dried, and ground into 500 μm to obtain a modified hydrogel;

[0073] (5) Add 60 g of calcium hydrogen phosphate, 20 g of choline chloride, 10 g of salt, and 4 g of baking soda to 1000 g of Chinese herbal medicine fermentation liquid, stir well, add 80 g of modified hydrogel, add 100 g of alfalfa powder and 60 g of whey powder while stirring, and then add 80 g of modified hydrogel, stir well, dry and crush at room temperature, and pass through a 100-mesh sieve to obtain the calf feed additive.

[0074] Example 4

[0075] A method for preparing a calf feed additive comprises the following steps:

[0076] (1) Weigh 50 g of Astragalus, 50 g of Gynostemma pentaphyllum, 50 g of Radish Seed, 50 g of Patchouli, 40 g of Lophatherum gracile, 30 g of Atractylodes lancea, 30 g of Cornus officinalis, 30 g of Hawthorn, 30 g of Tangerine peel, and 15 g of Licorice, dry at 60° C., and crush to 40 mesh to obtain Chinese herbal medicine powder; add the Chinese herbal medicine powder to water (the ratio of Chinese herbal medicine powder to water is 1 g: 10 mL), boil over high heat, keep warm over low heat for 60 min, and filter to obtain a Chinese herbal medicine extract; cool 400 g of the Chinese herbal medicine extract to room temperature, then add 70 g of a composite bacterial agent (Lactobacillus rhamnosus, Lactobacillus acidophilus, yeast, and Bifidobacterium animalis mixed in a weight ratio of 1:2.5:2.5:1.5) and 40 g of molasses, and perform anaerobically fermentation at 38° C. for 42 h. After the fermentation is completed, a Chinese herbal medicine fermentation liquid is obtained;

[0077] (2) 10 g of bentonite was dried and added to 200 mL of ethanol, and then 0.1 g of silica gel-loaded phosphoric acid and 3 g of lipoic acid were added, and the mixture was stirred and activated at 60° C. for 5 h, and the pH was adjusted to 2 with dilute hydrochloric acid, and the mixture was stirred and reacted at 60° C. for 10 h. The product was centrifuged, washed with alcohol, and dried to obtain pretreated bentonite;

[0078] (3) Dissolve 5 g of sodium alginate in 200 mL of 50 wt% ethanol solution, stir evenly, add 0.5 g of fumaric acid and 0.1 g of silica gel-supported phosphoric acid, stir and react at 60° C. for 10 h, filter the product, dialyze to remove unreacted products, and freeze-dry to obtain modified sodium alginate;

[0079] (4) Dispersing 10 g of pretreated bentonite and 5 g of modified sodium alginate into 200 mL of 50 wt% ethanol solution, stirring evenly, adding 0.1 g of phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt, and gradient freezing at -5 ° C for 48 h, placing the frozen solution under ultraviolet light for 5 min, mechanically crushing, freeze-drying, and grinding the product into 200 μm to obtain a modified hydrogel;

[0080] (5) Add 50 g of calcium hydrogen phosphate, 10 g of choline chloride, 5 g of salt, and 1 g of baking soda to 1000 g of Chinese herbal medicine fermentation liquid, stir evenly, add 50 g of modified hydrogel, add 80 g of alfalfa powder and 50 g of whey powder while stirring, and then add 50 g of modified hydrogel, stir evenly, dry and crush at room temperature, and pass through a 100-mesh sieve to obtain the calf feed additive.

[0081] Comparative Example 1

[0082] A method for preparing a calf feed additive comprises the following steps:

[0083] (1) Weigh 50 g of Astragalus, 50 g of Gynostemma pentaphyllum, 50 g of Radish Seed, 50 g of Patchouli, 40 g of Lophatherum gracile, 30 g of Atractylodes lancea, 30 g of Cornus officinalis, 30 g of Hawthorn, 30 g of Tangerine peel, and 15 g of Licorice, dry at 60° C., and crush to 40 mesh to obtain Chinese herbal medicine powder; add the Chinese herbal medicine powder to water (the ratio of Chinese herbal medicine powder to water is 1 g: 10 mL), boil over high heat, keep warm over low heat for 60 min, and filter to obtain a Chinese herbal medicine extract; cool 400 g of the Chinese herbal medicine extract to room temperature, then add 70 g of a composite bacterial agent (Lactobacillus rhamnosus, Lactobacillus acidophilus, yeast, and Bifidobacterium animalis mixed in a weight ratio of 1:2.5:2.5:1.5) and 40 g of molasses, and perform anaerobically fermentation at 38° C. for 42 h. After the fermentation is completed, a Chinese herbal medicine fermentation liquid is obtained;

[0084] (2) concentrating the Chinese herbal medicine fermentation liquid to obtain a paste with a relative density of 1.12, drying at room temperature, and grinding and crushing to 200 μm to obtain a Chinese herbal medicine concentrate;

[0085] (3) Add 100 g of calcium hydrogen phosphate, 30 g of choline chloride, 20 g of salt, 10 g of baking soda, 160 g of alfalfa powder, and 100 g of whey powder to 200 g of the Chinese herbal medicine concentrate, stir evenly, dry and grind at room temperature, and pass through a 100-mesh sieve to obtain the calf feed additive.

[0086] Comparative Example 2

[0087] A method for preparing a calf feed additive comprises the following steps:

[0088] (1) Weigh 50 g of Astragalus, 50 g of Gynostemma pentaphyllum, 50 g of Radish Seed, 50 g of Patchouli, 40 g of Lophatherum gracile, 30 g of Atractylodes lancea, 30 g of Cornus officinalis, 30 g of Hawthorn, 30 g of Tangerine peel, and 15 g of Licorice, dry at 60° C., and crush to 40 mesh to obtain Chinese herbal medicine powder; add the Chinese herbal medicine powder to water (the ratio of Chinese herbal medicine powder to water is 1 g: 10 mL), boil over high heat, keep warm over low heat for 60 min, and filter to obtain a Chinese herbal medicine extract; cool 400 g of the Chinese herbal medicine extract to room temperature, then add 70 g of a composite bacterial agent (Lactobacillus rhamnosus, Lactobacillus acidophilus, yeast, and Bifidobacterium animalis mixed in a weight ratio of 1:2.5:2.5:1.5) and 40 g of molasses, and perform anaerobically fermentation at 38° C. for 42 h. After the fermentation is completed, a Chinese herbal medicine fermentation liquid is obtained;

[0089] (2) Dissolve 10 g of sodium alginate in 200 mL of 50 wt% ethanol solution, stir evenly, add 4 g of fumaric acid and 2 g of silica gel-supported phosphoric acid, stir and react at 80° C. for 6 h, filter the product, dialyze to remove unreacted products, and freeze-dry to obtain modified sodium alginate;

[0090] (3) Dispersing 20 g of modified sodium alginate into 200 mL of 50 wt% ethanol solution, stirring evenly, adding 2 g of phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt, and gradient freezing at -80 ° C for 1 h, placing the frozen solution under ultraviolet light for 30 min, mechanically crushing, freeze-drying, and grinding the product into 500 μm to obtain cross-linked sodium alginate;

[0091] (4) Add 100 g of calcium hydrogen phosphate, 30 g of choline chloride, 20 g of salt, and 10 g of baking soda to 1000 g of Chinese herbal medicine fermentation liquid, stir well, add 150 g of cross-linked sodium alginate, add 160 g of alfalfa powder and 100 g of whey powder while stirring, and then add 150 g of cross-linked sodium alginate, stir well, dry and crush at room temperature, and pass through a 100-mesh sieve to obtain the calf feed additive.

[0092] Comparative Example 3

[0093] A method for preparing a calf feed additive comprises the following steps:

[0094] (1) Weigh 50 g of Astragalus, 50 g of Gynostemma pentaphyllum, 50 g of Radish Seed, 50 g of Patchouli, 40 g of Lophatherum gracile, 30 g of Atractylodes lancea, 30 g of Cornus officinalis, 30 g of Hawthorn, 30 g of Tangerine peel, and 15 g of Licorice, dry at 60° C., and crush to 40 mesh to obtain Chinese herbal medicine powder; add the Chinese herbal medicine powder to water (the ratio of Chinese herbal medicine powder to water is 1 g: 10 mL), boil over high heat, keep warm over low heat for 60 min, and filter to obtain a Chinese herbal medicine extract; cool 400 g of the Chinese herbal medicine extract to room temperature, then add 70 g of a composite bacterial agent (Lactobacillus rhamnosus, Lactobacillus acidophilus, yeast, and Bifidobacterium animalis mixed in a weight ratio of 1:2.5:2.5:1.5) and 40 g of molasses, and perform anaerobically fermentation at 38° C. for 42 h. After the fermentation is completed, a Chinese herbal medicine fermentation liquid is obtained;

[0095] (2) Add 100 g of calcium hydrogen phosphate, 30 g of choline chloride, 20 g of salt, and 10 g of baking soda to 1000 g of Chinese herbal medicine fermentation liquid, stir well, then add 150 g of bentonite, add 160 g of alfalfa powder and 100 g of whey powder while stirring, and then add 150 g of bentonite, stir well, dry and crush at room temperature, and pass through a 100-mesh sieve to obtain the calf feed additive.

[0096] The feed additives prepared in Examples 1 to 4 and Comparative Examples 1 to 3 were prepared with sterile water to obtain a viable bacterial count of 2×10 10 CFU / mL of bacterial solution was stored at 4°C for future use.

[0097] 1. Tolerance test of simulated gastric and intestinal fluids: Take 16.4 mL of 100 g / L hydrochloric acid and dilute it with distilled water to make the pH values ​​1.5, 2.5 and 3.5 respectively. Take 100 mL of dilute hydrochloric acid solution and add 1 g of pepsin to dissolve it fully to obtain simulated gastric fluid. The microporous filter membrane is sterilized (0.22 μm) for later use. Take 6.8 g of potassium dihydrogen phosphate and add 500 mL of water to dissolve it. Use 0.1 mol / L sodium hydroxide solution to adjust the pH value to 6.8; take 10 g of trypsin and add 100 mL of water to dissolve it. After mixing the two liquids, add water to dilute to 1000 mL to obtain simulated intestinal fluid. The microporous filter membrane is sterilized (0.22 μm) for later use. Take 1 mL of the preserved bacterial solution and add it to 9 mL of simulated gastric fluid (i.e., ten-fold stepwise dilution), and quickly mix it on an oscillator, and then place it at 30-45 ° C for 2-4 hours. The culture solution was taken out at 1h, 2h, 3h, and 4h, and the number of residual live bacteria was immediately counted, and compared with the original number of live bacteria to obtain the live bacteria survival rate. Then 1mL of the culture solution digested in artificial gastric juice for different times was taken, and inoculated into 9mL of artificial intestinal juice with a pH value of 6.8, and placed at 30-45℃ for 2-4h. Samples were taken at 0, 3, 6, and 24h, and the number of live bacteria was measured, and compared with the original number of live bacteria to obtain the live bacteria survival rate. Specific data are shown in Table 1.

[0098] 2. Simulated bile salt tolerance test: Use pancreatin to make a 1g / L solution, add 0.8% ox bile salt to the solution, adjust the pH to 8.0 with 10% NaOH, and then filter and sterilize with a 0.45μm microfiltration membrane. Inoculate 0.5mL of the preserved bacterial solution into 4.5mL of simulated bile salt, culture for 24h to obtain the culture solution, and count the number of remaining live bacteria. Dilute the culture solution tenfold in sterile saline to 10 -8 , and poured with MRS, then placed at 35℃ for 24h, sampled, and the number of live bacteria was determined, and compared with the original number of live bacteria to obtain the survival rate of live bacteria. Specific data are shown in Table 1.

[0099] Table 1 Survival rate of live bacteria in simulated gastric juice, intestinal juice and bile salt tolerance test (%)

[0100]

[0101] 3. Calf intestinal performance experiment: 35 healthy Holstein calves of 3 to 5 days of age and similar weight were selected and randomly divided into 7 groups. The feed additives prepared in Examples 1 to 4 and Comparative Examples 1 to 3 were added to the basic diet at a ratio of 0.8%; the measured nutritional level of the basic diet was: metabolic energy 13.24MJ / kg, crude protein 18.24%, crude fat 4.16%, crude ash 4.21%, neutral detergent fiber 14.79%, acid detergent fiber 9.36%, calcium 1.35%, phosphorus 0.72%; the experimental period was 56 days, and the calves were fed at 7:00 and 14:00 every day, and the calves were free to drink water. The rest was carried out according to the feeding and management standards of the farm. The weight of the calves was measured on the first and last day of the experiment, the average daily weight gain was calculated, and the total feed intake of the calf pellets during the experiment was recorded. The specific data are shown in Table 2.

[0102] Table 2 Effects of feed additives on calf growth performance

[0103]

[0104]

[0105] Three days before the end of the calf intestinal performance test, 100 g of feces from the calves in the seven experimental groups were collected daily for testing the fecal microbial content. The method for determining the number of Escherichia coli was based on GB / T 18869-2019, the method for determining the number of Salmonella was based on GB / T 13091-2018, and the method for determining the number of lactic acid bacteria was based on GB / T 4789.35-2016. The specific data are shown in Table 3.

[0106] Table 3 Effects of feed additives on intestinal flora of calves

[0107]

[0108] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A calf feed additive, characterized in that: The invention is prepared from the following components by weight: 100 parts of Chinese herbal medicine fermentation liquid, 10-30 parts of modified hydrogel, 8-16 parts of alfalfa powder, 5-10 parts of calcium hydrogen phosphate, 5-10 parts of whey powder, 1-3 parts of choline chloride, 0.5-2 parts of salt and 0.1-1 parts of baking soda.

2. The calf feed additive according to claim 1, characterized in that: The preparation method of the Chinese herbal medicine fermentation liquid comprises the following steps: weighing Chinese herbal medicine raw materials by weight, drying and crushing to obtain Chinese herbal medicine powder; adding the Chinese herbal medicine powder into water for steaming, filtering to obtain Chinese herbal medicine extract; cooling to room temperature, then adding composite bacterial agent and molasses for fermentation, and obtaining Chinese herbal medicine fermentation liquid after the fermentation is completed.

3. The calf feed additive according to claim 2, characterized in that: The Chinese herbal medicine raw materials are as follows by weight: 40-60 parts of astragalus, 40-60 parts of gynostemma pentaphyllum, 40-60 parts of radish seeds, 40-60 parts of patches of patches, 30-50 parts of lophatherum gracile, 20-40 parts of atractylodes, 20-40 parts of cornus officinalis, 20-40 parts of hawthorn, 20-40 parts of tangerine peel, and 10-20 parts of liquorice.

4. The calf feed additive according to claim 2, characterized in that: The drying process is carried out at 50-70°C and the powder is crushed to 20-50 mesh. The ratio of Chinese herbal medicine powder to water is 1g:8-10mL. The cooking conditions are boiling over high heat and keeping warm over low heat for 30-90min.

5. The calf feed additive according to claim 2, characterized in that: The composite bacterial agent is obtained by mixing Lactobacillus rhamnosus, Lactobacillus acidophilus, yeast and Bifidobacterium animalis in a weight ratio of 1:2~3:2~3:1~2; the weight ratio of Chinese herbal medicine extract: molasses: composite bacterial agent is 400:60~80:30~50; and the fermentation conditions are anaerobic fermentation at 35~40°C for 36~48h.

6. The calf feed additive according to claim 1, characterized in that: The preparation method of the modified hydrogel comprises the following steps: (1) drying bentonite, adding it to ethanol, then adding a solid acid catalyst and thioctic acid, stirring to activate, adjusting the pH, stirring to react, centrifuging the product, washing with alcohol, and drying to obtain pretreated bentonite; (2) dissolving sodium alginate in an ethanol solution, stirring evenly, adding fumaric acid and a solid acid catalyst, stirring to react, filtering the product, dialyzing to remove unreacted substances, and freeze-drying to obtain modified sodium alginate; (3) Dispersing the pretreated bentonite and modified sodium alginate into an ethanol solution, stirring evenly, adding phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt, performing gradient freezing treatment, placing the frozen solution under ultraviolet light, mechanically crushing, freeze-drying, and grinding the product to obtain a modified hydrogel.

7. The calf feed additive according to claim 6, characterized in that: In step (1), the amount ratio of bentonite, solid acid catalyst and thioctic acid is 10g:0.1~2g:3~6g; the stirring activation condition is stirring activation at 60~80°C for 2~5h; the pH is adjusted to 2~4 with dilute acid; and the stirring reaction condition is stirring reaction at 60~80°C for 6~10h.

8. The calf feed additive according to claim 6, characterized in that: In step (2), the concentration of the ethanol solution is 30-70 wt %; the ratio of sodium alginate, fumaric acid and solid acid catalyst is 5-10 g: 0.5-4 g: 0.1-2 g; and the stirring reaction conditions are 60-80 ° C and 6-10 h.

9. The calf feed additive according to claim 6, characterized in that: In step (3), the concentration of the ethanol solution is 30-70 wt %; the amount ratio of the pretreated bentonite, the modified sodium alginate, and the phenyl (2,4,6-trimethylbenzoyl) lithium phosphate is 10 g: 5-10 g: 0.1-2 g; the gradient freezing treatment is gradient freezing at -5--80° C. for 0.5-48 h; the ultraviolet light irradiation is 1-30 min; and the product is ground into 1-1000 μm.

10. A method for preparing the calf feed additive according to any one of claims 1 to 9, characterized in that: The method comprises the following steps: adding calcium hydrogen phosphate, choline chloride, salt and baking soda into Chinese herbal medicine fermentation liquid, adding half of the modified hydrogel after stirring evenly, adding alfalfa powder and whey powder under stirring, and then adding the remaining half of the modified hydrogel, stirring evenly, drying and crushing at room temperature, and passing through an 80-120 mesh sieve to obtain the calf feed additive.

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