Prescription and preparation method of rejoicing powder having new dosage form

A new dosage form, Kaixin technology, applied in the fields of medicine and biomedicine, can solve the problems of restricting the application and development of Kaixin Powder, and achieve the effect of convenient carrying and taking, product quality improvement, and reduction of dosage.

Inactive Publication Date: 2013-01-30
王登之
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Throughout the research on Kaixinsan preparations, traditional preparation methods are mainly used, which limits the application and development of Kaixinsan.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Prescription: Polygala 50g, Shichangpu 100g.

[0028] Preparation method: Polygala and Shichangpu are crushed and passed through a 80-mesh sieve. Mix the powder evenly in equal increments. Add 10% microcrystalline cellulose, 15% crospovidone, 6% sucrose, mix evenly, use 4% hydroxypropyl methylcellulose (606) alcohol solution as a binder to make a soft material, and pass through a 18-mesh sieve Granulate, dry at 60°C for 1 hour, pass through a 20-mesh sieve for granulation, add 0.6% magnesium stearate, mix evenly, fill into No. 0 or No. 1 capsules, and make hard capsules altogether.

Embodiment 2

[0030] Prescription: 50g each of ginseng, Polygala, and Shichangpu, and 100g of Poria cocos.

[0031] Preparation method: Ginseng, polygala and calamus are crushed and passed through a 80-mesh sieve, and Poria cocos is crushed and passed through a 150-mesh sieve. Mix the four medicinal powders evenly in equal increments. Add 20% microcrystalline cellulose, 25% disintegrant, the disintegrant is crospovidone and carboxymethyl starch sodium and mix evenly according to 1:1, use 1% carboxymethyl cellulose aqueous solution as binder Make soft material, pass through 18-mesh sieve to granulate, dry at 60°C for 1 hour, pass through 20-mesh sieve for granulation, add 6% micropowder silica gel and 0.6% magnesium stearate, mix evenly, test the intermediate, and press into tablets to form dispersible tablets.

Embodiment 3

[0033] prescription:

[0034] Medicinal materials: ginseng, polygala, calamus calamus, dodder, rehmannia glutinosa, digupi, schisandra, jujube seed, angelica, and chuanxiong, each taking 1000 grams (decoction pieces);

[0035] Excipients: polyethylene glycol 200, hydroxypropyl-β-cyclodextrin, sodium lauryl sulfate, borneol, purified water, ethanol.

[0036] Preparation:

[0037] 1. Wash 2-3 times with pure water, add eight times the amount of pure water, extract and filter the first extract by percolation at high temperature, and then use four times the amount of pure water to extract and filter the residue The second extraction solution; combine the second extraction solution and concentrate it into a thick paste for later use.

[0038] 2. Dissolve the auxiliary materials in 15% ethanol aqueous solution for later use.

[0039] 3. Add 1 thick paste to 2 ethanol aqueous solution, heat and stir to dissolve.

[0040] 4. Filtration, quality inspection.

[0041] 5. Filled in a...

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PUM

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Abstract

The invention relates to a prescription and a preparation method of rejoicing powder having a new dosage form and used for preventing or treating the senile dementia, and belongs to the biological medicine field. The rejoicing powder having a new dosage form is based on rejoicing powder having an ancient classic prescription and treats Radix Polygalae, Acorus gramineus and the like as primary medicines, the primary medicines are pretreated, partial or all medicines are extracted with water or an organic solvent in necessity to obtain effective components, the primary medicines or the effective components are mixed with proper medicinal auxiliary materials, and the rejoicing powder having the new dosage form is prepared through a certain preparation technology. The traditional prescription and the traditional technology for preparing the powder through simply crushing all medicines are changed in the invention, a new method and a new technology are applied against modern clinic medicine use characteristics to prepare the novel powder, and technological products have the characteristics of safety, effectiveness, controllable quality, convenient taking and the like of modern medicines, have the advantages of high biological utilization degrees of the effective components, fast effectiveness, substantial improvement of the product quality, and effective guarantee of the basic efficacies comprising qi benefiting, heart nourishing, nerve calming and tranquilizing, and have unique clinic application values in the prevention and the treatment of the senile dementia.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound Chinese medicine for preventing or treating senile dementia prepared by using traditional Chinese medicine as a raw material, and belongs to the field of biomedicine. Background technique [0002] Senile dementia is divided into Alzheimer's disease (AD), vascular dementia (VD), and the combination of the two. Among them, Alzheimer's disease accounts for 2 / 3 of the whole dementia, and has become the fourth killer of human beings. [0003] At present, there are about 129 million people over the age of 60 in my country, accounting for 10.15% of the total population. The prevalence rate of dementia in the elderly population is 3.0-4.0%, the prevalence rate of people over the age of 65 is 4.0-5.0%, and the prevalence rate of people over the age of 75 is about 10%, and about 20% are over 85 years old. It can be seen that the incidence rate doubles for every 10-year increase in the ag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61K36/9066A61K36/8888A61K36/8965A61K36/8968A61K36/8969A61K36/8967A61K36/8984A61K36/8945A61K9/00A61P25/28A61K35/56A61K35/32A61K35/10A61K35/02A61K35/586
Inventor 王登之喻苗苗朱盈周艳高建义
Owner 王登之
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