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Pharmaceutical composition for treating apparatus respiratorius disease and method for preparing the same

A respiratory system and composition technology, applied to respiratory diseases, drug combinations, pharmaceutical formulas, etc., can solve the problems of narrow antiviral spectrum, lack of support for cases, and no statistical processing, etc., to reduce production costs and improve antiviral spectrum Broad and strong medicinal effect

Inactive Publication Date: 2008-04-02
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the existing patents (applications) for anti-respiratory virus effects: CN 03100188.2 has no anti-inflammatory and analgesic effects, and its anti-viral spectrum is narrow, only anti-influenza virus A and B; CN 00100617.7 has no specific anti-viral pharmacological experimental basis, There are only a few cases of clinical treatment, and these cases lack support, the cases treated have no diagnostic basis for viral infection, no experimental data support, and the cases treated have no statistical processing; CN 03118301.8 only proposes that it has an "antiviral" effect , which specific viruses are not disclosed; the instructions of CN 02128077.0 only have prescriptions and preparation methods, and no antiviral pharmacodynamic data are disclosed. First, under the guidance of different quantitative change laws, hundreds of commonly used traditional Chinese medicines can evolve tens of millions of soup prescriptions, but the application description of this patent does not mention the measurement of the prescriptions; CN 03113857.8 patent specification page 4 It is recorded that it "has no obvious effect on the lung lesions and lung index of mice infected with influenza virus, and has no obvious effect on 10 strains of pathogenic bacteria in the respiratory system in vitro"; CN 94115927.2 is mainly used for cold and cold, and does not mention antiviral effect Pharmacological action; CN01129177.X only has antipyretic and anti-inflammatory effects; CN 96110520.8 only mentions "better than anti-influenza virus" on page 3 of the instructions, but no specific experimental data support

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0029] (1). Preparation of prescription drugs in groups 1-9

[0030] According to the prescribed amount in Table 2, weigh out 1-9 groups of prescription drugs consisting of 4 parts of hesperidin site, shegan glycoside site, puerarin site, and baicalin site; respectively formulate a concentration of 10mg / ml Aqueous solution.

[0031] (2). Anti-inflammatory experiment of mouse abdominal capillary permeability

[0032] 110 healthy male mice of 20-24g were randomly divided into 11 groups, and the prescription drugs of groups 1-9 were given respectively, and the dosage of administration was 0.20g / kg (0.4ml per 20g mouse); positive control Group Shuanghuanglian oral liquid 7.5ml / kg (equivalent to 11.25g crude drug / kg); blank control group was given equal volume of normal saline; continuous administration for 6 days, ig administration. One hour after the last administration, each mouse was given an intravenous injection of 0.5% Evans Blue physiological saline solution 0.1ml / 10g, followed...

Embodiment 1

[0127] Prescription: 86.58g for hesperidin, 129.87g for shegan glycoside, 173.16g for baicalin, 86.58g for puerarin.

[0128] Preparation method 1: Weigh the above-mentioned prescription amount of drug parts respectively (for the preparation method of the drug parts, see the following 1, 2, 3, and 4 in this embodiment), and mix them uniformly to form a CYHG drug.

[0129] Preparation method 2: Weigh the above-mentioned prescription amount of drug parts (see the following 1, 2, 3, and 4 for the preparation method of the drug parts) and appropriate amount of starch, mix them evenly, conventional wet granulation, drying, and packaging Into 1000 No. 0 hard capsules. Make CYHG capsules. Usage and dosage: Orally, 1-2 capsules at a time, 3 times a day. Specification: 0.5g / grain.

[0130] 1. Extraction process and quality standard of hesperidin part (ie hesperidin extract, the same text):

[0131] Extraction process of hesperidin parts: Take the citrus peel (or slag of the citrus peel) [t...

Embodiment 2

[0143] Example 2 CYHG pure product-preparation of mixture

[0144] Prescription: Hesperidin 2g, Shegan glycoside 3g, Baicalin 4g, Puerarin 2g

[0145] The raw materials used are all commercially available, and the raw materials extracted from plants or chemically synthesized can be used, and the content is not less than 90%; if necessary, it can be purified to more than 90%, such as 95%, by conventional methods.

[0146] Preparation method: Weigh the above-mentioned prescription drugs and mix them uniformly to form a pure CYHG-mixture.

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Abstract

The invention provides a drug combination to treat respiratory tract infection, containing hesperidin extracts, baicalin extracts, pueranin extracts and tectoridin extracts, and the preparation method of the drug combination. The drug combination has antipyretic, analgesic, antiphlogistic, antibacterial and antiviral functions and is especially suitable for treating upper respiratory tract infection.

Description

Technical field [0001] The invention belongs to a pharmaceutical composition for the treatment of respiratory system diseases and a preparation method thereof, in particular to a pharmaceutical composition mainly derived from botanicals which has the effect of curing and preventing respiratory system infections and an industrially applicable preparation method thereof. Background technique [0002] The clinical manifestations of respiratory viral infections are mainly: fever, headache, body pain, sore throat, coughing, pulmonary infection, and other upper, middle and lower respiratory tract inflammations. Therefore, the ideal drug for the treatment of respiratory viral infections should have solutions at the same time. Heat, anti-inflammatory, analgesic, antibacterial and antiviral effects. Among the patents (applications) that have anti-respiratory virus effects: CN 03100188.2 has no anti-inflammatory and analgesic effects, and its antiviral spectrum is narrow, only against infl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/758A61K36/88A61P11/00A61K131/00
Inventor 杨中林
Owner CHINA PHARM UNIV
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