Dispersible preparation adaptable to indissoluble drug

A technology for insoluble drugs and dispersants, which is used in drug delivery, organic active ingredients, plant/algae/fungus/moss ingredients, etc., to achieve the effects of fast onset, improved dissolution, and improved bioavailability

Inactive Publication Date: 2006-10-04
JC (WUXI) CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to overcome the defect of preparing dispersant by purely using physical barrier mechanism in the prior art, the present invention attempts to provide a new idea of ​​drug dispersant

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Phenylethyl isothiocyanate 5mg

[0051] Polyoxyl 40 Hydrogenated Castor Oil 125mg

[0052] Process: Mix phenylethyl isothiocyanate and polyoxyethylene 40 hydrogenated castor oil evenly, and fill hard capsules at 40°C.

Embodiment 2

[0054] Phenylethyl isothiocyanate 25mg

[0055] Polyoxyl 40 Hydrogenated Castor Oil 225mg

[0056] Process: Mix phenylethyl isothiocyanate and polyoxyethylene 40 hydrogenated castor oil evenly, and fill hard capsules at 40°C.

Embodiment 3

[0058] Phenylethyl isothiocyanate 25mg

[0059] Glyceryl monostearate (50 / 13) 125mg

[0060] Process: heating and melting phenylethyl isothiocyanate and glyceryl monostearate (50 / 13) and stirring evenly, filling hard capsules at 40°C.

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PUM

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Abstract

The invention discloses a dispersing agent for water non-soluble medicaments, which comprises, (1) 0.5-50 weight parts of active medicaments containing water non-soluble substance with a dissolvability of 0.001-10000mg/L of water at 25 deg C, (2) 0.5-1000 weight parts surface active agent or solubilizing agent with hydrophilyty and lipophilyty balance (HLB) >10.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a dispersant suitable for poorly water-soluble ingredients. Background technique [0002] Compared with other routes of administration, oral administration has obvious advantages, and it is no wonder that it is still one of the most important routes for drugs to enter the body. However, despite the advent of many new oral drug delivery technologies, the improvement of the solubility and dissolution rate of poorly water-soluble drugs is still one of the most challenging problems facing pharmacists today. [0003] It is well known that the release and absorption of drugs in preparations are closely related to the dispersion state of drugs. For insoluble drugs, if the dispersion state of the drug can be changed by changing the dosage form, prescription composition and process, it will undoubtedly improve the drug release properties and increase the b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K47/34A61K47/18A61K31/192A61K31/337A61K31/26A61K36/537A61K9/08A61K9/14A61K9/16A61K9/48A61K47/10A61K47/14A61K47/26
Inventor 程景才袁生良钟成娟
Owner JC (WUXI) CO INC
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