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Valnemulin hydrochloride emulsion for animals and preparation method thereof

A technology of vornimulin hydrochloride and vornier hydrochloride, which is applied in the directions of emulsion delivery, digestive system, respiratory system diseases, etc., can solve the problems of increasing drug toxicity and side effects, drug residues, drug resistance, and cost, etc. The effect of avoiding drug resistance, reducing residues, and reducing dosage

Inactive Publication Date: 2011-01-19
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If you want to increase the drug concentration in the target area, you must increase the dose, which not only increases the cost and causes waste of drugs, but also increases the side effects of drugs and drug residues in the body, increasing the possibility of drug resistance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The veterinary warnemulin hydrochloride emulsion of this embodiment mainly includes the following components by weight in every 100ml emulsion: 5 g of warnemulin hydrochloride, 1 g of gum arabic, 20 g of soybean oil, 5 g of ethanol, and the balance is water for injection. The emulsion is prepared through the following steps:

[0014] (1) Filter and sterilize warnemulin hydrochloride, gum arabic, soybean oil, ethanol, and water for injection respectively;

[0015] (2) Dissolve 5g of warnemulin hydrochloride in 5g of ethanol, then add 1g of gum arabic, 20g of soybean oil and water for injection to 100ml, mix well, and process repeatedly through a high-pressure homogenizer to obtain the product.

Embodiment 2

[0017] The veterinary warnemulin hydrochloride emulsion of the present embodiment mainly includes the following components by weight in every 100ml emulsion: 7.5g of warnemulin hydrochloride, 3g of Tween 80, 30g of castor oil, 8g of ethanol, and the balance is water for injection . The emulsion is prepared through the following steps:

[0018] (1) Filtrate and sterilize warnemulin hydrochloride, Tween 80, castor oil, ethanol, and water for injection, respectively;

[0019] (2) Dissolve 7.5g of warnemulin hydrochloride in 8g of ethanol, then add 3g of Tween 80, 30g of castor oil and water for injection to 100ml, mix well, and process repeatedly through a high-pressure homogenizer to obtain the product.

Embodiment 3

[0021] The veterinary warnemulin hydrochloride emulsion of the present embodiment mainly includes the following components by weight in every 100ml emulsion: 10 g of warnemulin hydrochloride, 2.5 g each of sodium oleate and Span 80, 20 g each of soybean oil and castor oil , ethanol 10g, and the balance is water for injection. The emulsion is prepared through the following steps:

[0022] (1) Filter and sterilize warnemulin hydrochloride, sodium oleate, Span 80, soybean oil, castor oil, ethanol, and water for injection, respectively;

[0023] (2) Dissolve 10g of warnemulin hydrochloride in 15g of ethanol, then add 2.5g each of sodium oleate and Span 80, 20g each of soybean oil and castor oil, and water for injection to 100ml, mix well, and homogenize by high pressure machine repeated processing, that is.

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PUM

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Abstract

The invention discloses valnemulin hydrochloride emulsion for animals. Each 100ml of emulsion mainly comprises the following components by weight: 5 to 10g of valnemulin hydrochloride, 1 to 5g of emulsifier, 20 to 40g of oil for injection, 5 to 15g of ethanol and the balance of water for injection. The valnemulin hydrochloride emulsion for animals has the advantages of quick in vivo distribution and good target, can reduce the medicament residue in vivo and the toxic or side effect on the animals, and also can mask the unpleasant odor of the medicament, and improve the stability of the medicament. The valnemulin hydrochloride emulsion for animals can effectively treat gram-positive bacteria and mycoplasma infection, particularly swine dysentery and porcine enzootic pneumonia, and can reduce the using amount of the medicament and avoid medicament tolerance.

Description

technical field [0001] The invention relates to a veterinary warnemulin hydrochloride emulsion and a preparation method of the emulsion, belonging to the technical field of veterinary medicine. Background technique [0002] Valnemulin and its salts are a new generation of pleuromutilin semi-synthetic animal-specific antibiotics, belonging to diterpenes, and are similar drugs to tiamulin. It is mainly used to prevent mycoplasma and Gram-positive bacteria infection in pigs, cattle, sheep and poultry. [0003] The pharmacokinetic characteristics of varnimulin are fast absorption, good drug effect, and high bioavailability, but the maintenance time of effective blood drug concentration is short, and the drug is eliminated quickly. The withdrawal period is 1d. Ordinary preparations of warnemulin, such as: premix, the drug is evenly distributed in the blood and tissues after administration, without targeting, and after the drug enters the blood circulation, it must bind to prote...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/22A61P31/04A61P1/12A61P11/00
Inventor 吴红云李建正李小娜
Owner ZHENGZHOU HOUYI PHARMA
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