Lornoxicam tablet and preparation process thereof

A technology of lornoxicam and preparation process, applied in the field of lornoxicam tablet and its preparation, can solve problems such as unsatisfactory curative effect and the like

Inactive Publication Date: 2014-08-20
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Existing drugs for the treatment of rheumatoid arthritis and painful osteoarthritis (arthrosis, degenerative joint disease) have unsatisfactory aspects such as curative effect

Method used

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  • Lornoxicam tablet and preparation process thereof
  • Lornoxicam tablet and preparation process thereof
  • Lornoxicam tablet and preparation process thereof

Examples

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Effect test

Embodiment Construction

[0019] The present invention is further explained below in conjunction with the examples, but the examples do not limit the present invention in any form.

[0020] (1) Making tablet cores: pass lornoxicam, lactose, pregelatinized starch, hydroxypropyl methylcellulose, and sodium starch glycolate through a 100-mesh sieve, and add them to the wet mixing granulator in equal increments Mix evenly to obtain mixed powder; dissolve polysorbate-80 in 30 to 50 times of ethanol, add it to the above mixed powder, mix, and then add 15% concentration of pregelatinized starch for pulping to the mixed powder to prepare Form into 18-40 mesh granules, dry at 60-70°C, granulate with 24-mesh sieve, collect when the moisture content is 1.0-3.0%, and prepare tablet cores for later use;

[0021] (2) Coating: the stomach-soluble film coating premix is ​​formulated with 80% ethanol into a 11% suspension, stirred and mixed for 60 minutes for later use; 2~3 rpm, adjust the distance of the spray gun to...

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Abstract

The invention discloses a lornoxicam tablet and a production process and application thereof. The lornoxicam tablet is prepared from lornoxicam, lactose, pregelatinized starch, hydroxypropylmethyl cellulose, carboxymethyl starch sodium, polysorbate-80, 15% starching pregelatinized starch, micro-powdered silica gel, magnesium stearate and a stomach dissolved type film coating premix. The production process comprises the steps of preparing a tablet core, coating and the like. According to the lornoxicam tablet, shown by treating 30 cases of rheumatoid arthritis, the anti-inflammatory and analgesic treatment effect is good, however, the influence on erythrocyte sedimentation rate is not great, and the total effective rate is 87%; the lornoxicam tablet has the characteristics that the number of medicine taking is small, the plasma concentration is stable, the duration is long and the like.

Description

technical field [0001] The invention relates to the field of chemical pharmacy, in particular to a lornoxicam tablet and a preparation process thereof. Background technique [0002] Arthritis is a common and chronic disease, in which osteoarthritis and rheumatoid arthritis are the main forms. According to reports, about 18% of the people in our country suffer from some form of arthritis, and the number of cases exceeds 200 million. Arthritis is a serious threat to human health, affecting the life and work of patients, making some patients unable to take care of themselves and lose their ability to work. Some patients have restricted activities, joint swelling, stiffness and pain, and severe joint permanent deformation, which is an important cause of disability in the elderly, so timely treatment is required. [0003] Lornoxicam (Lomoxicam), the chemical name is 6-chloro-4-hydroxy-2-methyl-3-(2-pyridinecarbamoyl)-2H-thieno[2,3-e]-l,2 - Thiazine-1,1-dioxide, which belongs t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/30A61K31/542A61P19/02A61P29/00A61K47/38
Inventor 于珂沈红卫
Owner QINGDAO MUNICIPAL HOSPITAL
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