Anthocyanin gastric floating microsphere and preparation method thereof
A technology of floating in the stomach and anthocyanins, which is applied in the field of medicine, can solve the problems of limited popularization, ineffective effects, and instability to light, etc., and achieve the effects of increasing drug absorption, avoiding peak-valley effects, and improving bioavailability
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Embodiment 1
[0026] Embodiment 1: the preparation of black wolfberry anthocyanin solution
[0027] (1) Take 10g of black wolfberry powder and add 100mL of 80% ethanol, extract twice under reflux in a water bath at 40°C, 60min each time, after cooling to room temperature, filter with suction, combine the filtrates, and concentrate to 15mL by rotary evaporation;
[0028] (2) Add 15mL of 95% ethanol to the concentrated solution, stir evenly, keep it away from light, put it in a refrigerator at 4°C overnight, take it out and filter it with suction;
[0029] (3) Concentrate the filtrate to 10 mL to obtain the black wolfberry anthocyanin solution.
Embodiment 2
[0030] Embodiment 2: the preparation of blueberry anthocyanin solution
[0031] (1) Take 10 g of blueberry powder, add 8 times the volume of 74% ethanol, and extract twice under reflux in a water bath at 62°C for 62 minutes each time. After cooling to room temperature, suction filter, combine the filtrates, and concentrate to 15 mL by rotary evaporation;
[0032] (2) Add 10mL of absolute ethanol to the concentrated solution, stir evenly, keep it in the dark at 4°C for overnight, take it out and filter it with suction;
[0033] (3) Concentrate the filtrate to 8 mL to obtain the blueberry anthocyanin solution.
Embodiment 3
[0034] Embodiment 3: the preparation of mulberry anthocyanin solution
[0035] (1) Take 10 g of mulberry powder and add 7 times the volume of 60% ethanol, extract twice under reflux in a water bath at 50°C, each time for 80 minutes, after cooling to room temperature, suction filter, combine the filtrates, and concentrate to 15 mL by rotary evaporation;
[0036] (2) Add 10mL of absolute ethanol to the concentrated solution, stir evenly, keep it in the dark at 4°C for overnight, take it out and filter it with suction;
[0037] (3) Concentrate the filtrate to 10 mL to obtain the mulberry anthocyanin solution.
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