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Method for preparing medicine of levo-stephandinine

A technology of L-stepherine and stepheridine, which is applied in the field of sustained-release preparations and preparations of the alkaloid-stepherine or L-stepharidine, which can solve the problems of slow onset of effect, sunk costs for patients, and release problems such as imbalance

Inactive Publication Date: 2006-01-04
CHENGDU YIPING MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing preparations are all common preparations, and there are many deficiencies, such as common tablets are used for a long time for the treatment of patients, and the natural herbal medicine extracts all have the characteristics of slow onset of effects, so they are not effective for patients. Taking medicine too many times a day is unfavorable; in addition, the way of taking medicine three times a day makes the blood drug concentration show a peak-valley effect, which is not conducive to the treatment of diseases; according to the point of view of "pharmaceutical economics", taking medicine once more will cause Doctors, nurses, and patients have huge sunk costs, resulting in a huge waste of resources
For long-term use of drugs, it is more beneficial to make them into sustained-release preparations, but for traditional Chinese medicine preparations, especially Chinese medicine products containing a large amount of alkaloids, it is quite difficult to make ordinary sustained-release preparations, such as the manufactured product There are defects such as unbalanced release, unstable preparation, excessive dosage, and difficult to overcome side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] L-stephenine sustained-release tablet (capsule): 25mg / tablet (capsule)

[0056] L-Stepherine 25.0g

[0057] Hydroxypropylmethylcellulose (HPMC K15M) 35.5g

[0058] Lactose 15.0g

[0059] Sodium alginate 20.0g

[0060] Carbomer 1.0g

[0061] Appropriate amount of PVP ethanol solution

[0062] A total of 1000 pieces (grains) were made

[0063] Preparation process: Grind stepherine, hypromellose, lactose, sodium trethalate, and carbomer through an 80-mesh sieve, mix evenly, granulate with PVP ethanol solution as a binder, dry, and granulate , ready to be pressed into tablets.

Embodiment 2

[0065] L-stephenine sustained-release tablet (capsule): 25mg / tablet (capsule)

[0066] L-Stepherine 25.0g

[0067] Hydroxypropylmethylcellulose (HPMC K15M) 35.5g

[0068] Lactose 15.0g

[0069] Sodium alginate 20.0g

[0070] Carbomer 1.0g

[0071] Appropriate amount of PVP ethanol solution

[0072] A total of 1000 pieces (grains) were made

[0073] Preparation process: Grind stepherine, hypromellose, lactose, sodium trethalate, and carbomer through an 80-mesh sieve, mix evenly, granulate with PVP ethanol solution as a binder, dry, and granulate , into capsules.

Embodiment 3

[0075] L-Stepherine Sustained Release Patch

[0076] A: Drug storehouse layer

[0077] L-Stepherine 10%

[0078] Polyacrylic resin 60%

[0079] Ethyl acetate 30%

[0080] Lauryl Alcohol 5%

[0081] B: Adhesive layer

[0082] L-Stepherine 3%

[0083] Polyacrylic resin 65%

[0084] Ethyl acetate 32%

[0085] Lauryl Alcohol 5%

[0086] Preparation process: Dissolve L-stephenidine and polyacrylic acid resin in ethyl acetate, mix them, add lauryl alcohol, coat the drug library ingredients on the aluminum-plastic film, dry at low temperature, recover the solvent, and take the pre-prepared polyacrylic acid resin. The propylene controlled release film is compounded with it. Another viscose component was coated on a 200 μm thick anti-sticking silicon paper, and after drying to remove the solvent, the viscose layer was obtained. Composite the viscose layer and the controlled-release membrane surface, and cut into ...

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Abstract

A process for preparing the slow-releasing stepholidine or levostepholidine is disclosed. Beside side stepholidine or levstepholidine, said medicine contains also the phamacologically receptable slow releasing material and carrier.

Description

Technical field: [0001] The invention relates to a new preparation of the traditional Chinese medicine steppawine, in particular to a slow-release preparation containing the alkaloid steppawine or L-stephenidine which is an extract of the Chinese herbal medicine steppawdine and a preparation method thereof. Background technique: [0002] Stephanidine is made from the alkaloids extracted from the Chinese herbal medicine Stephania genus Hanfang. It was first used in the 1970s and is mainly used to treat migraine, hyperkinetic movement disorder, and children's Tourette's syndrome. Existing preparations are all common preparations, and there are many deficiencies, such as common tablets are used for a long time for the treatment of patients, and the natural herbal medicine extracts all have the characteristics of slow onset of effects, so they are not effective for patients. Taking medicine too many times a day is unfavorable; in addition, the way of taking medicine three times ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4745A61K9/00A61K9/22A61K9/52A61K9/70A61P25/06A61P43/00
Inventor 李思宇
Owner CHENGDU YIPING MEDICAL SCI & TECH
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