Method for preparing medicine of levo-stephandinine

A technology of levothrinine and fenugreekine is applied in the field of new preparations of traditional Chinese medicine fenugreek, which can solve the problems of large dosage, insurmountable side effects, sunk costs for patients and the like

Inactive Publication Date: 2004-10-20
CHENGDU YIPING MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing preparations are all common preparations, and there are many deficiencies, such as common tablets are used for a long time for the treatment of patients, and the natural herbal medicine extracts all have the characteristics of slow onset of effects, so they are not effective for patients. Taking medicine too many times a day is unfavorable; in addition, the way of taking medicine three times a day makes the blood drug concentration show a peak-valley effect, which is not conducive to the treatment of diseases; according to the point of view of "pharmaceutical economics", taking medicine once more will cause Doctors, nurses, and patients have huge sunk costs, resulting in a huge waste of resources
For long-term use of drugs, it is more beneficial to make them into sustained-release preparations, but for traditional Chinese medicine preparations, especially Chinese medicine products containing a large amount of alkaloids, it is quite difficult to make ordinary sustained-release preparations, such as the manufactured product There are defects such as unbalanced release, unstable preparation, excessive dosage, and difficult to overcome side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Levocadopine sustained-release tablets (capsule): 25mg / tablet (capsule)

[0063] Levocadopine 25.0g

[0064] Hydroxypropyl methylcellulose (HPMC K15M) 35.5g

[0065] Lactose 15.0g

[0066] Sodium Alginate 20.0g

[0067] Carbomer 1.0g

[0068] PVP ethanol solution appropriate amount

[0069] A total of 1000 pieces (grains) are made

[0070] Preparation process: pulverize serratine, hypromellose, lactose, sodium seabathate, and carbomer through an 80-mesh sieve, mix well, granulate with PVP ethanol solution as a binder, dry and granulate , the tablet can be obtained.

Embodiment 2

[0072] Levocadopine sustained-release tablets (capsule): 25mg / tablet (capsule)

[0073] Levocadopine 25.0g

[0074] Hydroxypropyl methylcellulose (HPMC K15M) 35.5g

[0075] Lactose 15.0g

[0076] Sodium Alginate 20.0g

[0077] Carbomer 1.0g

[0078] PVP ethanol solution appropriate amount

[0079] A total of 1000 pieces (grains) are made

[0080] Preparation process: pulverize serratine, hypromellose, lactose, sodium seabathate, and carbomer through an 80-mesh sieve, mix well, granulate with PVP ethanol solution as a binder, dry and granulate , into capsules.

Embodiment 3

[0082] Levocadopine sustained-release patch

[0083] A: Drug store floor

[0084] Levocadopine 10%

[0085] Polyacrylic resin 60%

[0086] Ethyl acetate 30%

[0087] Lauryl alcohol 5%

[0088] B: Adhesive layer

[0089] Levocadopine 3%

[0090] Polyacrylic resin 65%

[0091] Ethyl acetate 32%

[0092] Lauryl alcohol 5%

[0093] Preparation process: Dissolve levothrinine and polyacrylic resin in ethyl acetate respectively, mix, add lauryl alcohol, coat the ingredients of the drug store on the aluminum-plastic film, dry at low temperature, recover the solvent, and take the pre-prepared polyacrylic acid. The propylene controlled release film is compounded with it. Another viscose component was coated on 200 μm thick release silicon paper, and after drying to remove the solvent, an adhesive layer was obtained. The adhesive layer is compounded with the controlled release film surface, and then cut into discs.

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PUM

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Abstract

A process for preparing the slow-releasing stepholidine or levostepholidine is disclosed. Beside side stepholidine or levstepholidine, said medicine contains also the phamacologically receptable slow releasing material and carrier.

Description

Technical field: [0001] The present invention relates to a new preparation of traditional Chinese medicine fenugreek, in particular to a sustained-release preparation containing alkaloids of Chinese herbal medicine fenugreek spp. fenugreek - fenugreekine or levorpinine, and a preparation method thereof. Background technique: [0002] Stemidine is made from the alkaloids extracted from the Chinese herbal medicine Radix chinensis. It was first used in the 1970s, mainly for the treatment of migraine, hyperkinetic movement disorder, Tourette's syndrome and other diseases. The existing preparations are all common preparations, and there are many shortcomings. For example, ordinary tablets are used for a long time for the treatment of patients, and the natural herbal medicine extracts have the characteristics of slow onset of action, so they are not suitable for patients. Taking the medicine too many times a day is unfavorable; in addition, the way of taking the medicine three tim...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/22A61K9/52A61K9/70A61K31/4745A61P25/06A61P43/00
Inventor 李思宇
Owner CHENGDU YIPING MEDICAL SCI & TECH
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