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Anthocyanin intragastric floating microspheres and preparation method thereof

A technology of floating in the stomach and anthocyanins, applied in the field of medicine, can solve the problems of limited popularization, ineffective effect, unstable light, etc., and achieve the effect of increasing drug absorption, avoiding peak-valley effect, and improving bioavailability

Active Publication Date: 2018-05-08
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, anthocyanins are easy to decompose under alkaline conditions, and are unstable to light, and their oral bioavailability in vivo is low, which limits their popularization and use.
For this reason, pharmacy researchers have carried out a lot of exploration and research on the preparation of anthocyanins, such as effervescent tablets and capsules, but the effect is not obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: the preparation of black wolfberry anthocyanin solution

[0027] (1) Take 10g of black wolfberry powder and add 100mL of 80% ethanol, extract twice under reflux in a water bath at 40°C, 60min each time, after cooling to room temperature, filter with suction, combine the filtrates, and concentrate to 15mL by rotary evaporation;

[0028] (2) Add 15mL of 95% ethanol to the concentrated solution, stir evenly, keep it away from light, put it in a refrigerator at 4°C overnight, take it out and filter it with suction;

[0029] (3) Concentrate the filtrate to 10 mL to obtain the black wolfberry anthocyanin solution.

Embodiment 2

[0030] Embodiment 2: the preparation of blueberry anthocyanin solution

[0031] (1) Take 10 g of blueberry powder, add 8 times the volume of 74% ethanol, and extract twice under reflux in a water bath at 62°C for 62 minutes each time. After cooling to room temperature, suction filter, combine the filtrates, and concentrate to 15 mL by rotary evaporation;

[0032] (2) Add 10mL of absolute ethanol to the concentrated solution, stir evenly, keep it in the dark at 4°C for overnight, take it out and filter it with suction;

[0033] (3) Concentrate the filtrate to 8 mL to obtain the blueberry anthocyanin solution.

Embodiment 3

[0034] Embodiment 3: the preparation of mulberry anthocyanin solution

[0035] (1) Take 10 g of mulberry powder and add 7 times the volume of 60% ethanol, extract twice under reflux in a water bath at 50°C, each time for 80 minutes, after cooling to room temperature, suction filter, combine the filtrates, and concentrate to 15 mL by rotary evaporation;

[0036] (2) Add 10mL of absolute ethanol to the concentrated solution, stir evenly, keep it in the dark at 4°C for overnight, take it out and filter it with suction;

[0037] (3) Concentrate the filtrate to 10 mL to obtain the mulberry anthocyanin solution.

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PUM

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Abstract

The invention relates to an anthocyanin gastric floating microsphere and a preparation method thereof, and belongs to the technical field of medicine. According to the technical scheme, an acid sodium alginate-anthocyanin solution is dropwise added to an alkali calcium chloride-chitosan solution; in the acid sodium alginate-anthocyanin solution, the weight-to-volume concentration of sodium alginate is 40-50 mg / mL, and the volume concentration of acid is 1.5-3.0%. In the alkali calcium chloride-chitosan solution, the weight-to-volume concentration of calcium chloride is 30-50 mg / mL, the weight-to-volume concentration of chitosan is 1.25-6.25 mg / mL, and the weight-to-volume concentration of alkali is 10-20 mg / mL. The prepared anthocyanin gastric floating microsphere is high in integrity, the encapsulation efficiency can reach 65% or above, the anthocyanin gastric floating microsphere has good floating performance, can immediately float and can keep floating for 12 hours or above, and the floating rate is 90% or above.

Description

technical field [0001] The invention relates to anthocyanin intragastric floating microspheres and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Anthocyanins have a strong antioxidant effect, can reduce the activity of oxidase, remove free radicals in the body, inhibit the absorption of cholesterol, anti-mutation, anti-tumor, anti-allergic, protect gastric mucosa, etc. In addition, anthocyanins have a protective effect on human vision. What has more health value and medicinal value is that anthocyanins can cross the blood-brain barrier and directly protect the central nervous system of the brain. [0003] However, anthocyanins are easy to decompose under alkaline conditions, are unstable to light, and have low oral bioavailability in vivo, which limits their popularization and use. For this reason, pharmaceutical researchers have carried out a lot of exploration and research on the preparation of anthocyanins, suc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K31/352A61K47/36A61P39/06A61P3/06A61P35/00A61P37/08A61P1/00A61P27/02A61P25/00
Inventor 韩静付艳秋金启文
Owner SHENYANG PHARMA UNIVERSITY
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