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Long-acting sustained-release medicaments for treating and renovating bone disease and preparation thereof

A carrier material and slow-release drug technology, which can be used in bone diseases, drug combinations, pharmaceutical formulations, etc. Bone cell growth, long drug release time, and the effect of promoting osteoblast growth

Inactive Publication Date: 2008-08-20
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the treatment of osteomyelitis focuses on the research of drug carrier materials on the one hand. The polymer drug carrier materials can control the time and rate of drug release, but cannot perform bone repair; on the other hand, inorganic bioceramics are also used as drug carrier materials, such as hydroxyphosphorus Limestone contains vancomycin for the treatment of osteomyelitis, but the release time of the drug is short, which cannot achieve the effect of long-acting sustained-release therapy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] Preparation of drug-loaded microspheres: adding chitosan to acetic acid aqueous solution to prepare a chitosan-acetic acid solution with a chitosan concentration of 2.0 wt%, adding tetracycline according to the chitosan and tetracycline mass ratio of 1: 1, completely dissolved as In the water phase of the W / O system, after the system is completely dispersed, add the crosslinking agent glutaraldehyde according to the volume ratio of the crosslinking agent and chitosan acetic acid solution at 1:10, the volume concentration of glutaraldehyde is 25%, and stir for about 3 hours. After fully reacting to form the chitosan drug-loaded microsphere core, after centrifugation, cleaning and drying, the particle size is measured with a laser particle size analyzer. Self-assembly of drug-loaded microsphere core coating layer: Prepare 1wt% sodium alginate aqueous solution and chitosan aqueous solution respectively, control the temperature at about 60°C, and 0.3M ion concentration, and di...

example 2

[0027] Preparation of drug-loaded microspheres: adding chitosan to aqueous acetic acid solution to prepare a chitosan-acetic acid solution with a chitosan concentration of 2.0 wt%, adding vancomycin according to the mass ratio of chitosan and vancomycin at 2:1 , as the water phase of the W / O system after completely dissolving, after the system is completely dispersed, add the crosslinking agent glutaraldehyde according to the volume ratio of the crosslinking agent and chitosan acetic acid solution at 1:10, the glutaraldehyde volume concentration is 25%, After fully reacting to form the chitosan drug-loaded microsphere core, after centrifugation, cleaning and drying, the particle size is measured with a laser particle size analyzer. Self-assembly of drug-loaded microsphere core coating layer: prepare 1wt% sodium alginate aqueous solution and chitosan aqueous solution respectively, control the temperature at about 60°C, and ionic concentration of about 0.3M, and disperse the prep...

example 3

[0030] Preparation of drug-loaded microspheres: adding chitosan to acetic acid aqueous solution to prepare a chitosan-acetic acid solution with a chitosan concentration of 2.0 wt%, adding gentamicin according to the mass ratio of chitosan and gentamicin at 1:1 As the water phase of the W / O system after complete dissolution, after the system is completely dispersed, add the cross-linking agent β-sodium glycerophosphate according to the volume ratio of the cross-linking agent and chitosan acetic acid solution 1:5, the mass of β-sodium glycerophosphate The concentration is 11%, stirred for about 3 hours, fully reacted to form the chitosan drug-loaded microsphere core, centrifuged, washed and dried, and measured with a laser particle size analyzer. Self-assembly of drug-loaded microsphere core coating layer: prepare 0.5wt% sodium alginate aqueous solution and chitosan aqueous solution respectively, control the temperature at about 40°C, and ionic concentration of about 0.5M, and di...

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Abstract

The invention discloses a long acting slow-release drug carrier material for therapy and repair of bone disease and preparation method; wherein, the components of the drug carrier material are 4-8 weight account of strontium-doped calcium polyphosphate, 1-3 weight account of chitosan drug-loaded microspheres and 1-3 weight account of chitosan; the preparation method of the compound drug carrier material for therapy of osteomyelitis and other bone diseases is that (1) the chitosan-acetic acid solution is prepared, (2) the strontium-doped calcium polyphosphate powder is put into the chitosan-acetic acid solution and dispersed evenly, (3) the prepared chitosan drug-loaded microspheres is added, (4) the cross-linking agent is added for cross-linking, (5) freezing at temperature of 2-6 DEG C is processed for 12-48 hours, and (6) heating and drying are processed at temperature of 40-100 DEG C. The drug carrier material has the advantages of being applicable to therapy and repair of osteomyelitis and other bone diseases, releasing antibiotic for a long period, bone repair function, good biocompatibility and degradability, and ideal double function of therapy and repair of osteomyelitis and other bone diseases.

Description

a technical field [0001] The invention relates to the technical field of biomedical material drug carriers, in particular to the technical field of long-acting slow-release drug carrier materials used for the treatment of osteomyelitis and other bone diseases and the repair of bone defects. Two background technology [0002] Traditional treatment of osteomyelitis usually includes surgical removal of infected tissue, washing with antiseptic solution, and 4 to 6 weeks of gastrointestinal antibiotic treatment. In order for the drug in the bone tissue to effectively kill bacteria, it is necessary to make the drug concentration in the bone tissue reach a bactericidal level, which requires prolonging the administration time and using antibiotics with high blood concentration. Due to the high incidence of disease associated with high blood levels of antibiotics, a number of topical drug delivery systems have been extensively studied and used. Carriers for topical administration of...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K47/02A61K9/16A61K45/08A61P19/08A61L27/20A61L27/12A61L27/54
Inventor 万昌秀史国齐余喜讯张小华李华王践云丁玉龙
Owner SICHUAN UNIV
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