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Drug-loaded silica embolism microsphere and preparation method thereof

A technology of silica and embolization microspheres, applied in the fields of polymer materials and biomedical engineering

Inactive Publication Date: 2014-04-30
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention intends to prepare silica microspheres as embolic microspheres for embolization therapy, but considering that when clinically performing vascular embolization for patients, two Silica microspheres are not easy to stably disperse in injection solution or iodized oil developer, and the microspheres tend to aggregate into clusters, which can block injection needles or embolization catheters, making surgical operations difficult

Method used

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  • Drug-loaded silica embolism microsphere and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (2) Add 10 grams of silica microspheres into 100 mL of toluene, ultrasonically disperse for 10 minutes, then add 4 grams of silane coupling agent KH-560, in a reactor equipped with a reflux condensation device, raise the temperature to 80°C, Stir and react for 12 hours, after centrifugation, wash with acetone and centrifuge three times, and vacuum dry at room temperature to obtain a white powder; add the white powder to 100mL solvent N,N-dimethylformamide, ultrasonically disperse evenly, add 2 g Sodium azide and 1.6 g of ammonium chloride were vigorously stirred at 50° C. for 40 hours; washed with a large amount of water and filtered to remove inorganic salts, and then vacuum-dried to obtain 9.8 g of azide-modified silica microspheres.

[0028] (3) Take 2 grams of polyethylene glycol containing alkyne terminal prepared in step (1) and dissolve it in 80 mL of water / n-butanol mixed solvent, add the azide-modified silica prepared in step (2) 9.8 grams of microspheres, disp...

Embodiment 2

[0033] (2) Add 8 grams of silica microspheres into 80 mL of toluene, ultrasonically disperse for 10 minutes, then add 3 grams of silane coupling agent KH-560, in a reactor equipped with a reflux condensing device, raise the temperature to 110 ° C at a constant speed Stir and react for 9 hours, after centrifugation, wash with acetone and centrifuge 3 times, dry under vacuum at room temperature to obtain a white powder; add the white powder to 80mL solvent N,N-dimethylformamide, ultrasonically disperse evenly, add 1.6g Sodium azide and 1.4 g of ammonium chloride were vigorously stirred at 50° C. for 35 hours; washed with a large amount of water and filtered to remove inorganic salts, and dried in vacuum after filtration to obtain 7.8 g of azide-modified silica microspheres.

[0034](3) Take 5 grams of polyethylene glycol containing alkyne terminal prepared in step (1) and dissolve it in 100 mL of water / n-butanol mixed solvent, add the azide-modified silica prepared in step (2) 7...

Embodiment 3

[0039] (2) Add 30 grams of silica microspheres to 250 mL of toluene, ultrasonically disperse for 10 minutes, then add 8 grams of silane coupling agent KH-560, in a reactor equipped with a reflux condensation device, raise the temperature to 100 ° C, uniform Stir the reaction for 10 hours, after centrifugation, wash with acetone and centrifuge three times, and vacuum dry at room temperature to obtain a white powder; add the white powder to 250mL solvent N,N-dimethylformamide, ultrasonically disperse evenly, add 4 g Sodium azide and 3.2 grams of ammonium chloride were vigorously stirred at 50° C. for 48 hours; washed with a large amount of water and filtered to remove inorganic salts, and dried in vacuum after filtration to obtain 28.2 grams of azide-modified silica microspheres.

[0040] (3) Take 5 grams of polyethylene glycol containing alkyne terminal prepared in step (1) and dissolve it in 300 mL of water / n-butanol mixed solvent, add the azide-modified silica prepared in step...

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Abstract

The invention belongs to the field of polymer material and biomedical engineering, particularly relates to drug-loaded silica embolism microsphere and a preparation method thereof. Through technical improvement, silica microsphere is prepared into micron microsphere, hydrophilic polyethylene glycol coupling agent is coupled onto the surface of silica microsphere by efficient Huisgen cycloaddition reaction to form a neutral hydrophilic layer, so that the microspheres can be stably and uniformly dispersed in an aqueous medium to facilitate operation of arterial embolization; meanwhile, silica embolism microsphere has a nano porous structure which can adsorb chemicals, so as to reach the purpose of slow release of drug for treatment while achieving arterial embolization, which further improves the therapeutic effect. The embolism microsphere provided by the invention has good histocompatibility, is mainly used for arterial embolization treatment of diseases, especially suitable for arterial embolization treatment of hepatic tumor, and has broad application prospect.

Description

technical field [0001] The invention belongs to the fields of polymer materials and biomedical engineering, and in particular relates to a drug-loaded silicon dioxide embolization microsphere and a preparation method thereof. Background technique [0002] Silica microspheres are widely used in coatings, catalysts, optics, biomedicine and other fields due to their fine internal structure and uniform and smooth surface characteristics. Since Stäber invented the hydrolysis of alkoxide to prepare silica microspheres in 1968, its preparation method has been continuously developed and improved. At present, the methods for preparing silica microspheres mainly include spray-drying method, polymerization-induced colloidal aggregation method, sol-gel method, bio-microcapsule method, etc. Due to its controllable particle size, high mechanical strength, good chemical stability and thermal stability, rich silanol on the surface and easy surface modification, it has rich modification spa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/02A61L31/16A61K9/16A61K45/00A61K47/34A61K47/04A61P35/00
Inventor 李建波冷俊昭任杰李茂全袁伟忠
Owner TONGJI UNIV
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