Waterproof and breathable bionic artificial skin and preparation method thereof

A technology of artificial skin and dermis layer, applied in the field of bionic artificial skin and its preparation, can solve the problems of slow degradation of silk fibroin, insignificant effect of scaffold, affecting skin healing effect, etc., and achieves the promotion of regeneration, good flexibility and mechanical strength Effect

Active Publication Date: 2015-11-11
BEIJING PAISHENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dermis of this skin is easy to dissolve without cross-linking operation, the scaffolding effect is not obvious, the thickness is only less than 0.17mm, and the silk fibroin used in the epidermis to increase the mechanical strength degrades slowly, and even the epidermis needs to be peeled off when using it. Affects skin healing
[0005]

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 : Bionic artificial skin, composed of protective layer, epidermis and dermis. The protective layer is a non-degradable silica gel film with micropores, the epidermis is composed of a degradable and absorbable collagen film with a microporous structure, and the dermis is a collagen sponge structure.

[0032] The preparation method of bionic artificial skin is as follows:

[0033] Step 1: Using 0.1% acetic acid aqueous solution as a solvent, take a certain amount of collagen, configure a collagen solution with a concentration of 1 wt%, put it into a dialysis bag and dialyze for 9 days to form solution I;

[0034] Step 2: Using 0.1% acetic acid aqueous solution as a solvent, take a certain amount of collagen, and prepare a 0.5wt% collagen solution;

[0035]Step 3: Inject solution 2 into a mold with a depth of 5mm, freeze-dry at -80°C to form a sponge, and then use an ethanol solution with a concentration of 0.05% formaldehyde for cross-linking. After cross-link...

Embodiment 2

[0037] Example 2: The bionic artificial skin is composed of protective layer, epidermis and dermis. The protective layer is a non-degradable polyurethane film with micropores, the epidermis is composed of a degradable and absorbable collagen film with a microporous structure, and the dermis is a sponge composed of a blend of collagen and hyaluronic acid.

[0038] The preparation method of bionic artificial skin is as follows:

[0039] Step 1: Using 1.1% acetic acid aqueous solution as a solvent, take a certain amount of collagen, configure a collagen solution with a concentration of 1.3wt%, put it into a dialysis bag and dialyze for 7 days to form solution I;

[0040] Step 2: Take 0.5% acetic acid aqueous solution as solvent, take a certain amount of collagen and sodium hyaluronate, and configure a mixed solution with a concentration of 0.7wt% collagen and sodium hyaluronate, wherein the weight ratio of collagen and sodium hyaluronate 2:1;

[0041] Step 3: inject solution ...

Embodiment 3

[0043] Example 3 : Bionic artificial skin, composed of protective layer, epidermis and dermis. The protective layer is a non-degradable silica gel film, the epidermis is composed of degradable and absorbable collagen and chitosan blend film with microporous structure, and the dermis is a sponge of collagen and sodium hyaluronate blend material.

[0044] The preparation method of bionic artificial skin is as follows:

[0045] Step 1: Take 0.5% propionic acid aqueous solution as a solvent, take a certain amount of collagen and chitosan, configure a concentration of 0.3wt% collagen solution, wherein the weight ratio of collagen and chitosan is 3:1, load Dialyze in the dialysis bag for 4 days to form solution I;

[0046] Step 2: Take 1% propionic acid aqueous solution as solvent, take a certain amount of collagen and sodium hyaluronate, and configure a mixed solution of 0.5wt% collagen and sodium hyaluronate, wherein the weight of collagen and sodium hyaluronate The ratio is 1...

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Abstract

The invention relates to a bionic artificial skin. The artificial skin comprises a protective layer, an epidermal layer, and a corium layer, and is characterized in that the protective layer is composed of polymer films, which contain micro pores, are non-degradable, or have a low degrading speed; the epidermal layer is composed of biopolymer, which contains a micro pore structure and can be degraded and absorbed; and the corium layer is composed of biopolymer sponge that can be degraded and absorbed. The protective layer has a waterproof and moisture permeable function; the material of the epidermal layer is the same as the human epidermis and has a micro pore structure, thus the artificial skin has a similar oxygen and moisture permeable function as that of human skin, the artificial skin is enabled to have a breathable function, the epidermal layer and corium layer of the artificial skin can be degraded, and moreover, because the components of the epidermal layer and corium layer are similar to human skin, and degradation products can promote the regeneration of epidermal cells and fibroblast. The invention also provides a preparation method of the bionic artificial skin.

Description

technical field [0001] The invention belongs to the field of tissue engineering biomedical materials and medical devices, and relates to a bionic artificial skin with waterproof and breathable functions and a preparation method thereof. Background technique [0002] The current artificial dermis substitute materials include heterogeneous acellular dermal matrix, cell-free extracellular matrix dermal substitute, and dermal substitute containing allogeneic cells. Each has its own advantages and disadvantages in clinical application. The heterogeneous acellular dermal matrix is ​​the earliest permanent dermal substitute developed from a heterogeneous source. The main disadvantages are the lack of viable fibroblasts, collagen may cause immune reactions, and there is a risk of spreading viruses. Dermal substitute materials with allogeneic cells have disadvantages such as difficulty in preservation and high application costs, and extracellular matrix dermal substitutes without cel...

Claims

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Application Information

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IPC IPC(8): A61L27/60A61L27/50A61L27/58A61L27/56A61L27/40A61F2/10
Inventor 张自强其他发明人请求不公开姓名
Owner BEIJING PAISHENG BIOTECH CO LTD
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