Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyalurons

a technology of hyaluron and hyaluron, which is applied in the field of compositions and methods for treating the cellular response to injury and/or the abnormal proliferation of cells, can solve the problems of severe limitations in the efficacy of current medical treatments, the toxicity of current reagents, and the typical toxicity of therapeutic approaches, so as to prevent tissue disorder or cell proliferation
US20050058646A1Inactive Publication Date: 2005-03-17TURLEY EVA +1
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
TURLEY EVA
Publication Date
2005-03-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides compositions and methods for treating a tissue disorder associated with a response-to-injury process or proliferating cells in a mammal. These tissue disorders are associated with a novel cellular phenotype designated as “transition cells” which are described herein. This cellular phenotype is characterized in having an activated erk kinase signaling activity, a stimulated AP-1 binding activity, and at least one characteristic selected from the group consisting of: (a) increased podosome formation, (b) increased flux of intracellular or extracellular hyaluronans or hyaladherins, (c) increased expression of a hyaladherin, (d) an inability to form focal adhesions, (e) increased metalloproteinase activity, and (f) increased expression of a hyaladherin. Example tissue disorders include fibrosis, inflammation, degeneration and invasive disorders such as occur in cancerous cells. The methods provided herein include administering to the mammal, an effective amount of a composition that alters the activity of transition molecules within a cell Transition molecules are shown to be comprised of hyaladherins, hyaluronans and associated molecules that regulate the transitional phenotype. A novel cell culture comprising transition cells is also provided, as well as compositions comprising particular peptides, polypeptides, and antibodies that affect the transitional phenotype.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation-in-part of U.S. patent application Ser. No. 09 / 541,5227 filed Apr. 3, 2000; which application claims the priority to U.S. Provisional Patent Application No. 60 / 127,457, filed Apr. 1, 1999, all of which applications are incorporated by reference in their entirety.TECHNICAL FIELD

[0002] The present invention relates generally to the understanding, diagnosis and treatment of a wide variety of diseases, and more specifically, to compositions and methods for treating cellular response to injury and / or the abnormal proliferation of cells. BACKGROUND OF THE INVENTION

[0003] The normal cell in normal tissue is confined to a narrow range of function and structure regulated by its differentiation state, genetic program of metabolism, tissue specialization, by constraints induced by neighboring cells, the extracellular matrix and availability of exogenous factors and metabolic substrates. Cells are able to handle...

Claims

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