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467 results about "Cellular imaging" patented technology
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Nitrogen, phosphorus and sulphur doping or co-doping carbon dot and batch controllable preparing method and application thereof
InactiveCN104987863ASimple processShort synthesis timeNanoopticsFluorescence/phosphorescenceAir atmosphereSilica gel
The invention provides a nitrogen, phosphorus and sulphur doping or co-doping carbon dot and a batch controllable preparing method and application thereof. The method comprises the steps that a carbon source, a nitrogen source, a phosphorus source and a sulphur source are evenly mixed, and a mixture is obtained, wherein the molar ratio of C to N to P to S in the mixture is 1 to 0-0.8 to 0-0.4 to 0-0.4, and the contents of N, P and S are prevented from being zero at the same time; in the air, the mixture is heated to be fused, the reaction is carried out for 3 min to 60 min, natural cooling is carried out till the indoor temperature is reached, a reaction product is separated by a silicagel column, raw materials which do not react are removed, and the nitrogen, phosphorus and sulphur doping or co-doping carbon dot is obtained. According to the method, the technology is simple, the compound time is short, batch producing can be achieved, the doping amount can be adjusted and controlled accurately, the fluorescence color of the prepared carbon dot ranges from blue to green, the application can be achieved on bioluminescence marking and cell imaging aspects, and the good economic benefit and the application prospect are achieved.
Owner:XI AN JIAOTONG UNIV
Compositions and Methods for Cellular Imaging and Therapy
ActiveUS20070248537A1Shorten the timeReduce wasteGroup 3/13 element organic compoundsDiagnostic recording/measuringRadionuclide imagingMedical physics
The present invention relates generally to the fields of chemistry and radionuclide imaging. More particularly, it concerns compositions, kits and methods for imaging and therapy involving N4 compounds and derivatives.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Dynamic imaging of biological cells and other subjects
ActiveUS20070182959A1Quick observationRadiation pyrometrySpectrum investigationMicroscopic imageMultivariate analysis
The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.
Owner:CHEMIMAGE CORP
Metallic Nanostructures Adapted for Electromagnetic Field Enhancement
ActiveUS20090213369A1Heavy metal active ingredientsMaterial nanotechnologyElectromagnetic fieldMolecular medicine
The disclosure relates to metallic nanophotonic crescent structures, or “nanocrescent SERS probes,” that enhance detectable signals to facilitate molecular detections. More particularly, the nanocrescent SERS probes of the disclosure possess specialized geometries, including an edge surrounding the opening that is capable of enhancing local electromagnetic fields. Nanosystems utilizing such structures are particularly useful in the medical field for detecting rare molecular targets, biomolecular cellular imaging, and in molecular medicine.
Owner:RGT UNIV OF CALIFORNIA
Multilayer fluorescent nanoparticles and methods of making and using same
InactiveUS20160018404A1Minimize energy transferNot decrease relative fluorescence emissionUltrasonic/sonic/infrasonic diagnosticsSurgeryMaterials scienceFluorescent nanoparticles
A multilayer, fluorescently responsive material (FRM)-containing nanoparticle and compositions comprising such nano-particles. The nanoparticles can be made using a layer-by-layer deposition method. The nanoparticles can be used in imaging methods such as, for example, cellular imaging methods.
Owner:CORNELL UNIVERSITY
Rare earth-doped lithium lutetium fluoride nano-material, and preparation method and application thereof
ActiveCN103589432AEasy to makeSynthesis conditions are easy to controlFluorescence/phosphorescenceLuminescent compositionsBio moleculesContrast medium
The invention discloses a rare earth-doped lithium lutetium fluoride nano-material, and a preparation method and an application thereof. The material is obtained by doping Yb / Er(20 / 1%) or Yb / Tm(20 / 0.5%) luminescent ions into a lithium lutetium fluoride matrix, can emit visible light under the excitation of 980nm infrared light, and can be used for the up-conversion heterogeneous detection and cell imaging through the connection with biological molecules. Additionally, heavy rare earth ions in the matrix also have a strong X-ray attenuation capability, and can be used as a computer tomography imaging contrast agent. The invention also provides the preparation method of the nano-material. The nano-material has a water solubility and excellent performances, so the nano-material can be applied in the fields of the biological detection, the biological imaging and the like.
Owner:FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
N, P and S-codoped fluorescent carbon quantum dot and preparation method and application thereof
InactiveCN105567228AEasy to operateWide variety of sourcesNanoopticsFluorescence/phosphorescenceEscherichia coliFreeze-drying
The invention provides an N, P and S-codoped fluorescent carbon quantum dot and a preparation method and application thereof, and belongs to the technical field of luminescent nanomaterials. The preparation method comprises the steps that a biological bacterium (saccharomycete or escherichia coli or staphylococcus aureus or aspergillus niger) is taken as a carbon source, water of the corresponding volume is added, and a hydrothermal reaction is performed to obtain a dark brown solution; after the reaction stops and a reaction kettle is naturally cooled, dialysis is performed to remove impurities, an aqueous carbon quantum dot solution is obtained, and after freeze drying is performed, the N, P and S-codoped fluorescent carbon quantum dot is obtained. According to the method, the biomass is taken as the carbon source, the raw material is wide in source, low in cost, green and environmentally friendly, the technology is simple, and the preparation condition requirement is low. The obtained carbon quantum dot can be applied to detection on Cr (VI) ions, MnO4<-> and ascorbic acid by serving as a switch-type fluorescent probe and also can be used for cell imaging.
Owner:SHANXI UNIV
Preparation method and application of carbon dot/gold composite nanoparticles
ActiveCN106141200AHigh quantum yieldSmall sizeLuminescent compositionsQuantum yieldSurface-active agents
The invention discloses a preparation method and application of carbon dot / gold composite nanoparticles. Citric acid and cysteine are taken as raw materials, and N-S codoping carbon dots are synthesized; the carbon dots serve as the heterogeneous nucleation center of the gold nanoparticles, a reducing agent and a stabilizing agent, any other auxiliaries such as a surface active agent or an adsorbent do not need to be added, and the carbon dot / gold composite nanoparticles are prepared by further reducing chloroauric acid. The preparation method of the carbon dot / gold composite nanoparticles is simple, convenient, feasible, mild in reaction condition and environmentally friendly, and the prepared carbon dot / gold composite nanoparticles have the characteristics of being high in quantum yield, small in size, low in biotoxicity, resistant to photobleaching and the like, and can be applied to the fields such as cell imaging or catalytic reaction research.
Owner:SHANGHAI JIAO TONG UNIV
Devices and methods for imaging particular cells including eosinophils
InactiveUS20110137178A1Easy to installFaster and high resolutionDiagnostics using spectroscopyDianostics using fluorescence emissionMast cellEosinophil
An exemplary embodiment of apparatus and method according to the present disclosure can be provided. For example, using at least one first arrangement, it is possible to direct at least one first electro-magnetic radiation to at least one portion of tissue within a body. Using at least one second arrangement, it is possible to receive at least one second electro-magnetic radiation provided from the portion, which is based on the first electro-magnetic radiation. Further, using at least one third arrangement, it is possible to differentiate at least one particular cell which is eosinophil, mast cell, basophil, monocyte and / or nutrophil from other cells in the portion based on the second electro-magnetic radiation.
Owner:THE GENERAL HOSPITAL CORP
System and method of illuminating living cells for imaging
ActiveUS7141801B2Reduce coincidenceMinimizing rateRadiation pyrometrySpectrum investigationExcited stateLiving cell
A system and method of providing illumination for a cell imaging system delivering modulated light for illumination of a sample. Modulation of illumination intensity may be effectuated by pulsing the output of a light source, for example, or by selectively interrupting light provided by the source. Such modulated illumination may have particular utility in applications where reducing the number of electrons in a super-excited state may minimize the rate of photobleaching and photodamage in the molecules being studied.
Owner:LEICA MICROSYSTEMS CMS GMBH
Aie luminogens for bacteria imaging, killing, photodynamic therapy and antibiotics screening, and their methods of manufacturing
ActiveCN107001927ASimplify the imaging processEasy to filterGroup 4/14 element organic compoundsOrganic active ingredientsPhotodynamic therapyCritical micelle concentration
The invention relates to synthesis of fluorescent molecules with aggregation-induced emission (AIE) characteristics and application as fluorescent probes for cellular imaging, killing, and antibiotic screening, wherein the cells are bacteria or mammalian cells. The fluorescent molecules generate reactive oxygen species (ROS) upon light irradiation. The invention also relates to a probe comprising fluorescent molecules exhibiting AIE phenomenon, wherein the probe is used for bacterial and biological study. The invention further relates to a method of imaging and quantifying bacterial, a method of killing cells, a method of high throughput antibiotics screening and determining bacteria resistance, a method of photodynamic therapy, and a method of determining critical micelle concentration.
Owner:THE HONG KONG UNIV OF SCI & TECH
Methods for preparation of ZnTe nanocrystals
ActiveUS8637082B2Minimize and prevent incorporationImprove stabilityUltrasonic/sonic/infrasonic diagnosticsPowder deliveryQuantum yieldProtein blotting
Nanocrystals having a ZnTe core and methods for making and using them to construct core-shell nanocrystals are described. These core-shell nanocrystals are highly stable and provide quantum yields and stability suitable for applications such as flow cytometry, cellular imaging, and protein blotting, medical imaging, and other applications where cadmium toxicity is an issue.
Owner:LIFE TECH CORP
Precision optical intracellular near field imaging/spectroscopy technology
InactiveUS7129454B2Facilitates molecular analysisMore powerSolid-state devicesMaterial analysis by optical meansDiseaseMolecular analysis
A Precision Optical Intracellular Near Field Imaging / Spectroscopy Technology (POINT / NANOPOINT) is a high-resolution instrument for analyzing and comparing molecular characteristics of cells. A nanosensor array is provided which is capable of imaging inner regions of living cells without destroying its natural environment and providing new information about molecular makeup of cells. The POINT probe collects data from high-resolution imagery, providing an imaging tool for investigating cells at sub-cellular and molecular levels. Data are then incorporated into a signature facilitating molecular analysis of diseases. The POINT probe non-invasively penetrates cell membranes to image insides of intact cells allowing the POINT probe to collect data without destroying cell structures. The probe provides cellular imaging to enable the viewing of both imaging and spectroscopy of internal regions of cells. The POINT system may be attached to existing microscopes to achieve a very high resolution.
Owner:NANOPOINTS
Endoscopic imaging device
An endoscopic imaging device for endoscopy in a body vessel is disclosed. The device comprises an annular illumination tube comprising an annular illumination fiber for illuminating a body vessel during endoscopy. The device further includes a first imaging tube comprising a first imaging fiber for gross examination and navigation through the body vessel. The first imaging fiber is disposed within the annular illumination tube. The device further comprises a second imaging tube comprising a second imaging fiber for cellular imaging. The second illumination fiber is disposed adjacent the first imaging tube and within the annular illumination tube.
Owner:PURDUE RES FOUND INC
Method for using DNA tetrahedron as scaffold on nano-particle surface and initiating rolling circle amplification reaction
InactiveCN104388563AEffective control of distribution densityImprove hybridization efficiencyMicrobiological testing/measurementSingle strandA-DNA
The invention relates to a method for using a DNA tetrahedron as a scaffold on a nano-particle surface and initiating rolling circle amplification reaction; after the prepared DNA tetrahedron is assembled on the nano-particle surface, a section of single-stranded DNA extending on the DNA tetrahedron can be used as primer DNA; circular DNA complementary with a special aptamer sequence is used as an amplification template; the circular DNA is hybridized with the primer DNA while the rolling circle amplification reaction is initiated; and the prepared product is multiple long single-stranded DNA composed of multiple apatmer structures on the nano-particle surface. The method disclosed by the invention is capable of effectively regulating and controlling the DNA distribution density on the nano-particle surface, so that the hybridization efficiency of the primer DNA and the circular DNA is increased; by means of long single-stranded DNA composed of the multiple aptamer structures prepared through the rolling circle amplification technology, the CTC (Carbon Tetra Choride) capture efficiency is greatly increased; and thus, the method disclosed by the invention has potential application value in the research fields, such as cell detection, cell capture, cell imaging and the like.
Owner:SHANGHAI NAT ENG RES CENT FORNANOTECH
Multi-functional fluorescence carbon quantum dots and preparation method and application thereof
ActiveCN108410457AEasy to prepareShort reaction timeMeasurement devicesLuminescent compositionsEthylenediamineFreeze-drying
The invention provides multi-functional fluorescence carbon quantum dots and a preparation method and application thereof. The preparation method of the carbon quantum dots comprises the following steps: by taking phthalic acid as a raw material, adding ethanediamine and strong phosphoric acid to obtain a pale yellow solid slice, after reaction is stopped, naturally cooling to room temperature, adding ultrapure water, stirring to obtain a pale yellow solution, filtering with a filter membrane, and freeze-drying to obtain nitrogen phosphorus codoped fluorescence carbon quantum dot powder. The preparation process of the carbon quantum dots is simple, the raw material is wide in source and low-cost, and the preparation method is simple and fast; the prepared carbon quantum dots are stable inoptical property and good in biocompatibility, not only can be used for detecting manganese ions in traditional Chinese medicines and tea leaves, but also can serve as a temperature sensor, and meanwhile can be used for cell imaging.
Owner:SHANXI UNIV
A method of preparing fluorescent carbon dots by adopting waste sugarcane molasses as a raw material and application of the fluorescent carbon dots
ActiveCN106634978ALow priceThe synthesis process is simpleMaterial analysis using wave/particle radiationMicrobiological testing/measurementFreeze-dryingBiocompatibility Testing
A method of preparing fluorescent carbon dots by adopting waste sugarcane molasses as a raw material and application of the fluorescent carbon dots are disclosed. The method includes weighing 4.0-6.0 g of the waste sugarcane molasses, performing pyrolysis at 240-260 DGE C, adding 4-6 mL of deionized water, filtering the mixture with a filter membrane having a pore size of 0.22 [mu]m, adding dropwise the filtrate into absolute ethanol, performing centrifugation for 5 min at a rotating speed of 6000 round / min, collecting a clear liquid, performing vacuum concentrating to remove the ethanol, adding the deionized water again, filtering the mixture with the filter membrane having a pore size of 0.22 [mu]m, collecting a filtrate, and freeze-drying the filtrate to obtain the fluorescent carbon dots. A preparing process of the fluorescent carbon dots is simple and raw materials are cheap. The fluorescent carbon dots have characteristics of good biocompatibility, good bleaching resistance performance, high optical stability, excellent fluorescent properties, and the like, and can be used for cell imaging and used for content detection of a food coloring agent that is sunset yellow.
Owner:GUANGXI ACAD OF SCI
Ratio-type pH fluorescence probe for water-soluble locating lysosome as well as preparation method, application and test method of ratio-type pH fluorescence probe
ActiveCN105524079AEliminate outside influenceImprove detection accuracyOrganic chemistryMaterial analysis by observing effect on chemical indicatorSolubilityLysosome
The invention provides a ratio-type pH fluorescence probe for water-soluble locating lysosome as well as a preparation method, an application and a test method of the ratio-type pH fluorescence probe. The chemical structural formula of the ratio-type pH fluorescence probe is shown in the specification. The probe can detect changes of strength of fluorescence with two emission wavelengths simultaneously, external influences are eliminated through self-calibration, the detection accuracy is high, the speed of response to pH changes is high, and the probe has excellent water solubility and has very good anti-interference capacity in the existence of various metal ions. The fluorescence strength changes remarkably in the pH range from 5.8 to 6.8, and the probe is suitable for pH detection under a weak acidic condition. Experiments prove that the probe can selectively dye lysosome in cells, the light stability in the cells is good, and the probe is non-toxic to the cells and can be used for pH detection of live cells. The probe has very important application value in cell imaging and detection of changes of the pH value in lysosome.
Owner:TAISHAN MEDICAL UNIV
Luminogen compounds and the use of the same for biosensing and cellular imaging
ActiveUS20120237964A1High selectivityRapid and sensitive and selective detectionOrganic chemistryComponent separationLuminophoreThio-
Provided herein are a luminogen compound of formula (I) including a AIE luminophore moiety conjugated with a maleimide moiety and a use of the same for detecting thiol groups in biomolecules. Also provided is a dye molecule, a biosensor or a bioprobe comprising the luminogen compound of formula (I) in use for detecting thiol groups in biomolecules. The detection method of the present subject matter not only has high thio-selectivity and sensitivity, but also is rapid, convenient and handy.
Owner:THE HONG KONG UNIV OF SCI & TECH
Spectrally-encoded high-extinction polarization microscope and methods of use
Described herein is a polarization microscope that uses spectral-encoding of the polarization state for cellular imaging. The spectral-encoded polarization microscope is both sufficiently fast for cellular imaging and is compatible with high extinction optics required to image molecular structures and assemblies. The spectral-encoded microscope allows for the polarization state of light presented to the specimen to sample discrete states over the entirety of the Poincaré sphere while simultaneously giving a null measurement of the observed cellular birefringence. Sampling over the entire Poincaré sphere allows the microscope to determine of specimen phase retardation due to both linear and circular birefringence. The spectral-encoded polarization microscope can be operated in a slightly off-null state that will improve signal-to-noise.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Water-soluble compounds with aggregation-induced emission characteristics
The present subject matter relates to water-soluble, fluorescent compounds that have aggregation-induced emission (AIE) characteristics and exhibit near infrared (NIR) absorption. The compounds can beutilized as plasma-membrane specific bio-probes in cell imaging through a wash-free and fast staining procedure. In addition, the compounds can efficiently generate reactive oxygen species (ROS) in vivo when irradiated with visible light. As such, the compounds can be effective in killing cancer cells through image-guided, photodynamic therapy (PDT) processes.
Owner:THE HONG KONG UNIV OF SCI & TECH
Construction and application of gold-magnetic nanoparticle-based medicament carrying platform
InactiveCN101716348AEasy to separateStrong magnetismOrganic active ingredientsPharmaceutical non-active ingredientsProtonationPolyethylene glycol
The invention relates to the construction and application of a gold-magnetic nanoparticle-based medicament carrying platform, which belong to the technical field of magnetic nanophase materials. The construction comprises the synthesis of magnetic nanoparticles, the synthesis of an Fe3O4-SiO2 nuclear shell structure, the amine surface modification of the Fe3O4-SiO2 nuclear shell structure, protonation and the electrostatic adherence of gold nanoparticles after the surface modification, the coupling of curcumin and the coupling of mercapto polyethylene glycol PEG-SH so as to prepare a multifunctional gold-magnetic nano-platform. The construction and the application have the following advantages that: the gold-magnetic nanoparticle-based medicament carrying platform is a magnetic carrier with a modified surface and has the characteristics of relatively stronger magnetism, good chemical inertness, biocompatibility, easy functionalization and the like, and can be prepared by a simple method; and the magnetic nanophase materials can be quickly separated with a magnetic field in a suspension system, are highly concentrated and act on tumor cells under the guidance of an external magnetic field, and can be applied in biological fields, such as bioseparation, medicament transportation, biological tags, cell imaging and developing and study on the separation of cells or other biomolecules.
Owner:JIANGNAN UNIV
Preparation method and application of BODIPY (boron-dipyrromethene) and Cys (cysteine) fluorescent probe
InactiveCN106432315AEnhanced fluorescence emission peakGood choiceGroup 3/13 element organic compoundsFluorescence/phosphorescenceThiolStructural formula
The invention discloses a preparation method and an application of a boron-dipyrromethene (BODIPY) based fluorescent probe for determining cysteine (Cys). The structural formula of the probe is shown in the specification. The preparation method of the BODIPY derivative based Cys fluorescent probe with a simple structure is provided, and the BODIPY derivative based Cys fluorescent probe is used for directly measuring Cys concentration. In the system, the fluorescent probe shows good selectivity and is not interfered with other biological thiols (Hcy and GSH) and other 19 amino acids. The probe shows quite high sensitivity to Cys, and the fluorescence intensity is enhanced by 23 times when 3 equivalents of Cys are added. When the pH is between 6.0 and 8.0, determination of Cys by the fluorescent probe is not affected by pH. The fluorescence probe and Cys act quickly, and the response time is within 6 minutes. In addition, the probe can also be used in cell imaging to detect intracellular Cys.
Owner:XIANGTAN UNIV
High-throughput single-cell imaging, sorting, and isolation
The invention provides a method and apparatus for isolating individual target cells. The apparatus includes a body structure comprising a main channel, a collection channel, and a waste channel fluidly coupled at a first fluid junction. A plurality of trapping channels intersect the collection channel, each trapping channel having a diameter at a location adjacent to the intersection of the trapping channel with the collection channel that is less than a diameter of an individual target cell. The apparatus also includes an imaging system configured to image individual target and non-target cells within the main channel, thereby producing imaging data; a processor configured to perform real-time, multivariate analyses of the imaging data; and a directing system configured to direct the individual target cells. A pressure source is in fluid communication with one or more of the collection channel, the waste channel, the first side channel, and the second side channel.
Owner:CAPLIPER LIFE SCI INC
Sulfur quantum dot and preparation method and application thereof
ActiveCN110734763AHigh fluorescence intensityGood water solubilityPhotodynamic therapyNanoopticsPolyethylene glycolPhysical chemistry
The invention provides a sulfur quantum dot as well as a preparation method and application thereof. The preparation method comprises the following steps: adding sulfur powder into a dispersion systemfor ultrasonic treatment to obtain dispersion liquid; wherein the dispersion system comprises polyethylene glycol and hydrogen peroxide; transferring the dispersion liquid into a reaction kettle forsolvothermal reaction; and after the reaction is finished, naturally cooling to room temperature and adjusting the pH value to be neutral to obtain the sulfur quantum dot. The sulfur quantum dot prepared by the method is high in yield, rich in surface functional groups, relatively small in size, relatively uniform in particle size distribution, good in water solubility, good in dispersity, good inbiocompatibility and excellent in fluorescence property, and can be widely applied to the fields of cell imaging, ion detection and the like.
Owner:CHINA UNIV OF PETROLEUM (BEIJING)
Preparation method and application of phosphorus-doped fluorescent carbon quantum dots
InactiveCN105950145AEasy to operateWide variety of sourcesFluorescence/phosphorescenceLuminescent compositionsFreeze-dryingPhytic acid
The invention relates to a preparation method of phosphorus-doped fluorescent carbon quantum dots. The preparation method comprises the following steps: (1) adding phytic acid into a glass container, then adding secondary water, fully stirring, and carrying out ultrasonic treatment to obtain a clear solution; then, rapidly adding the clear solution into phosphorus pentoxide to obtain a dark brown solution; (2) after the glass container is naturally cooled, filtering the dark brown solution by using filter paper, and removing undissolved substance to obtain a clear dark brown solution; (3) separating by means of exclusion chromatography, wherein sephadex G-25 is taken as filler, and water is taken as a mobile phase, and separating according to time order to obtain three carbon quantum dot aqueous solutions; (4) respectively carrying out freeze drying on the three carbon quantum dot aqueous solutions to obtain three target products. The method is simple in operation technology, wide in source of raw materials, low in price of the raw materials, low in requirement for separation conditions and free from energy consumption; the obtained carbon quantum dots are stable in optical properties. The prepared phosphorus-doped fluorescent carbon quantum dots can be used for Fe<3+> ion detection, tetracycline detection and cell imaging.
Owner:SHANXI UNIV
Methods of generating florescence resonance energy transfer (FRET) between semiconductor quantum dots and fluorescent dyes/proteins via multi-photon excitation, achieving zero background or direct excitation contributions to the fret signature
InactiveUS20100075361A1Microbiological testing/measurementAnalysis by material excitationSemiconductor quantum dotsBiomolecule
A system and method of sensing physiological conditions in biological applications includes a laser source for optically exciting a plurality of luminescent quantum dots and a plurality of biomolecules in a nanoscale sensing system having a nanocrystal structure, where the plurality of biomolecules is stained with dye. In a multi-photon excitation process, a laser system optically excites, the plurality of luminescent quantum dots and the plurality of biomolecules in the nanoscale sensing system, where fluorescence resonance energy transfer (FRET) occurs between the plurality of quantum dots and the plurality of biomolecules. Stability of self assembly of quantum dot peptide conjugates within the plurality of biomolecules is investigated. Physiological conditions at the cellular level are determined, using a spectrometer to sense fluorosence spectra. The sensing of physiological conditions includes transducing signals into immunoassays, clinical diagnostics and cellular imaging to provide treatment to biological subjects including human patients.
Owner:UNITED STATES OF AMERICA GOVT REPRESENTED BY THE SECRDETARY OF THE NAVY CHIEF OF NAVAL RES ONR NRL
Stimulated emission loss fluorescent lifetime super-resolution imaging device
InactiveCN109211871ABig life changeSmall lifetime changeFluorescence/phosphorescenceSynchronous controlLive cell imaging
Owner:SHENZHEN UNIV
Boron-nitrogen co-doped carbon quantum dot as well as preparation and application thereof
ActiveCN110982520ANo obvious morphological damageObvious morphological damageMaterial nanotechnologyNanoopticsFluoProbesQuantum yield
The invention relates to a boron-nitrogen co-doped carbon quantum dot which is prepared by taking o-phenylenediamine as a carbon source and a nitrogen source, boric acid as a boron source doping agent, through microwave-assisted hydrothermal reaction in water and reaction product purification. The boron-nitrogen co-doped carbon quantum dot prepared by the invention has a particle size of less than10nm, can emit yellow fluorescence with a long wavelength of 560nm under excitation, has high fluorescence quantum yield, has excitation independence, low toxicity and good biocompatibility, and canbe used as a fluorescent probe in cell imaging.
Owner:TAIYUAN UNIV OF TECH
Relatively long emission wavelength fluorescent carbon quantum dot and preparation method thereof
InactiveCN109097036AWide variety of sourcesEmission wavelength controllableLuminescent compositionsSolubilityRoom temperature
The invention discloses a relatively long emission wavelength fluorescent carbon quantum dot and a preparation method thereof. According to the method, L-ascorbic acid is used as a carbon source, anda certain proportion of passivating agents and solvents is added and uniformly mixed with L-ascorbic acid to obtain a clear transparent solution; the mixed liquid is placed in a reaction kettle for areaction for a few hours at high temperature and then is naturally cooled to room temperature; the reaction liquid is subjected to separation and purification treatment, and a fluorescent carbon quantum dot solution is obtained. The preparation method provided by the invention has the advantages of simple process, mild condition, low production cost and environmental protection; the prepared carbon quantum dots have a relatively long fluorescence emission wavelength, can achieve controllable emission wavelength, good water solubility, diversity of surface properties, uniform distribution of particle size and other characteristics by adding different types of passivating agents, and can be widely used in cell imaging, biomarker, biochemical sensing and other fields.
Owner:CHINA PHARM UNIV
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