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Rare earth-doped lithium lutetium fluoride nano-material, and preparation method and application thereof

A technology of rare earth doping and lithium lutetium fluoride, which is applied in the direction of luminescent materials, material excitation analysis, chemical instruments and methods, etc., can solve the problems of little research on lithium lutetium fluoride, and achieve excellent luminescence performance, convenient operation, and synthesis The effect of easily controlled conditions

Active Publication Date: 2014-02-19
FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on rare earth doped fluorides mainly focuses on sodium yttrium fluoride (NaYF 4 ), sodium gadolinium fluoride (NaGdF 4 ) or lithium yttrium fluoride (LiYF 4 ) and other systems, for lithium lutetium fluoride (LiLuF 4 ) is rarely studied
However, there are no reports on the synthesis, optical properties and applications of monodisperse water-soluble rare earth-doped lithium lutetium fluoride nano-fluorescence labeling materials.

Method used

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  • Rare earth-doped lithium lutetium fluoride nano-material, and preparation method and application thereof
  • Rare earth-doped lithium lutetium fluoride nano-material, and preparation method and application thereof
  • Rare earth-doped lithium lutetium fluoride nano-material, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0036] Example 1: LiLuF 4 : Preparation of 1%Er, 20%Yb nanoparticles. Weigh 0.120gLi(CF 3 COO) 2 ·H 2 O, 0.449g Lu(CH 3 COO) 3 4H 2 O, 0.006g Er(CH 3 COO) 3 4H 2 O and 0.113g Yb(CH 3 COO) 3 4H 2 O, then add 6mL oleic acid, 6mL oleylamine and 2mL octadecene, heat to 120°C with nitrogen gas and keep it warm for 30 minutes to form a transparent solution. And washing to get about 28nm oil-soluble LiLuF 4 : 1% Er, 20% Yb nanoparticles. Add 112 μL of concentrated hydrochloric acid to 15 mL of absolute ethanol to prepare an acidic solution of pH 1. Disperse oil-soluble nanocrystals in the above-mentioned acidic ethanol solution, centrifuge after ultrasonication for 30 minutes, and alternately wash several times with absolute ethanol and water to obtain water-soluble LiLuF of about 28 nm. 4 : 1%Er, 20%Yb nanocrystals.

example 2

[0037] Example 2: LiLuF 4 : Preparation of 0.5%Tm, 20%Yb nanoparticles. Weigh 0.120gLi(CF 3 COO) 2 ·H 2 O, 0.452g Lu(CH 3 COO) 3 4H 2 O, 0.003g Tm(CH 3 COO) 3 4H 2 O and 0.113g Yb(CH 3 COO) 3 4H 2 O, then add 6mL oleic acid, 6mL oleylamine and 2mL octadecene, heat to 120°C with nitrogen gas and keep it warm for 30 minutes to form a transparent solution. And washing to get about 28nm oil-soluble LiLuF 4 : 0.5%Tm, 20%Yb nanoparticles. Disperse the oil-soluble nanocrystals in the acidic ethanol solution as described in Example 1, centrifuge after ultrasonication for 30 minutes, and alternately wash several times with absolute ethanol and water to obtain a water-soluble LiLuF of about 28 nm. 4 : 0.5%Tm, 20%Yb nanocrystals.

[0038] Example 3: LiLuF 4 : 1%Er, 20%YbLiLuF 4 Preparation of 8-layer coated core-shell nanoparticles. First, weigh 0.120g Li(CF 3 COO) 2 ·H 2 O and 0.568g Lu(CH 3 COO) 3 4H 2 O, then add 9mL oleic acid, 9mL oleylamine and 2mL octadecen...

example 6

[0041] Example 6: LiLuF 4 : 0.5%Tm, 20%YbLiLuF 4 Preparation of 16-layer coated core-shell nanoparticles. First, weigh 0.240g Li(CF 3 COO) 2 ·H 2 O and 1.136g Lu(CH 3 COO) 3 4H 2O, then add 18mL oleic acid, 18mL oleylamine and 4mL octadecene, heat to 120°C with nitrogen gas and keep it warm for 30 minutes to form a transparent solution, then cool down to room temperature to obtain the shell precursor solution A. As described in Example 2, the temperature was raised to 320°C and kept warm for 40 minutes to form solution B. Take 2mL of A and inject it into B, and keep warm at 320°C for 10 minutes; then inject 2mL of A again, and keep warm at 320°C for 10 minutes; Cool down to room temperature, add 30mL acetone to precipitate, separate and wash to obtain about 50nm oil-soluble LiLuF 4 : 0.5%Tm, 20%YbLiLuF 4 16 layers of coated core-shell nanoparticles. Disperse the oil-soluble nanocrystals in the acidic ethanol solution as described in Example 1, centrifuge after ultras...

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Abstract

The invention discloses a rare earth-doped lithium lutetium fluoride nano-material, and a preparation method and an application thereof. The material is obtained by doping Yb / Er(20 / 1%) or Yb / Tm(20 / 0.5%) luminescent ions into a lithium lutetium fluoride matrix, can emit visible light under the excitation of 980nm infrared light, and can be used for the up-conversion heterogeneous detection and cell imaging through the connection with biological molecules. Additionally, heavy rare earth ions in the matrix also have a strong X-ray attenuation capability, and can be used as a computer tomography imaging contrast agent. The invention also provides the preparation method of the nano-material. The nano-material has a water solubility and excellent performances, so the nano-material can be applied in the fields of the biological detection, the biological imaging and the like.

Description

technical field [0001] The invention relates to the field of nano-luminescent materials, in particular to a rare-earth nano-luminescent material that can be used for biological detection and imaging and a preparation method thereof. Background technique [0002] In recent years, rare earth-doped upconversion luminescent nanomaterials have shown great application value in photoconductive switches, information storage, optoelectronic devices, and solar cells, among which the most notable is the recent rise of rare earth-doped upconversion luminescent nanomaterials. Applications of materials in fluorescent biomarkers. Compared with traditional fluorescent labeling materials (such as fluorescent dyes and quantum dots), rare earth-doped upconversion luminescent nanomaterials not only have high chemical stability, long fluorescence lifetime, and low potential biological toxicity, but also have a large It has significant advantages such as high light penetration depth, no autofluo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/85G01N21/64
Inventor 陈学元黄萍郑伟涂大涛朱浩淼
Owner FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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