The invention discloses a clad plate preparation method of micro methanol battery, the modified polymethyl methacryate is the basis materials, the high conductivity copper is conductive layer, and the nickel is as the anti-corrosion protective material. Adopting non-siliceous composite preparation technology, firstly producing the master mask and silicon rubber soft mould; then adopting the craft of 'inverse autogram' to stamp the micro channel of flow field on the modified polymethyl methacryate whose substrate is glass; then depositing the copper on surface of micro channel with craft of plating, a layer of nickel is plated on the substrate of the copper, then the composite deposite is nitration surface modified treatment; at last, after eliminating the glass substrate, producing the imports and exports of the reactants and resultant by laser micromachining. The polymer/copper nickel base clad plate possesses advantages that the weight is light, the volume is small, performance is well, cost is low, and it fits for batch size production.