Compound florfenicol injection and preparation method and application thereof

A technology of compound florfenicol and florfenicol, which is applied in the direction of medical formulas, medical preparations containing active ingredients, respiratory diseases, etc., can solve the problems of poor bioavailability and inconvenient use, and achieve convenient clinical use , Saving production costs, the effect of reasonable composition

Active Publication Date: 2011-09-21
GUANGDONG WENS DAHUANONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to provide a kind of compound Florfenicol injection according to the poor bioavailability existing in the

Method used

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  • Compound florfenicol injection and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 250g of N-methyl-2-pyrrolidone, add 100g of florfenicol injection-grade raw material, stir to dissolve it, and set aside; take another 400g of propylene glycol, heat it to 60~80°C, add the prescribed amount of flunixin glucagon Mix 9 g of amine and 10 g of local analgesic benzyl alcohol, stir to dissolve, cool to about 40°C, mix with the stock solution, add polyethylene glycol 200 to the full amount, filter, pot, and sterilize at 100°C for 30 minutes to obtain.

Embodiment 2

[0029] Take 250g of N-methyl-2-pyrrolidone, add 100g of florfenicol injection-grade raw material, stir to dissolve, set aside; take another 400g of glycerin formal, heat to 60~80℃, add the prescribed amount of flunixin Mix 9g of meglumine and 10g of local analgesic benzyl alcohol, stir to dissolve, cool to about 40°C, mix with the reserve solution, add polyethylene glycol 200 to the full amount, filter, pot, sterilize at 100°C for 30 minutes, and obtain .

Embodiment 3

[0031] Take 250g of N-methyl-2-pyrrolidone, add 250g of florfenicol injection-grade raw materials, stir to dissolve, and set aside; take another 400g of propylene glycol, heat to 60~80°C, add the prescribed amount of flunixin glucagon Mix 23 g of amine and 10 g of local analgesic benzyl alcohol, stir to dissolve, cool to about 40°C, mix with the reserve solution, add polyethylene glycol 300 to the full amount, filter, pot, and sterilize at 100°C for 30 minutes to obtain the product.

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PUM

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Abstract

The invention discloses compound florfenicol injection and a preparation method and application thereof. The compound florfenicol injection comprises main medicaments, injection solvent and local anodyne; and the main medicaments are florfenicol and flunixin meglumine. The compound florfenicol injection is safe and convenient to use, controllable in quality, stable in preparation process, suitable for industrialized production and low in cost; and the compound florfenicol enhances the prevention and treatment effects of porcine or bovine respiratory diseases, improves the survival rate of pigs or cattle, and is suitable for popularization and application.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a compound florfenicol injection and a preparation method and application thereof. Background technique [0002] With the improvement of scale and the increase of breeding density, respiratory infectious diseases have become an important class of infectious diseases that affect the healthy development of the pig and cattle industry. The main symptoms are respiratory syndrome, and the sick pigs are depressed and have fever. Difficulty breathing, panting, coughing, sneezing, mucus or thick secretions from the nostrils, meningitis, swollen eyelids, abdominal breathing, loss of appetite, slow growth, emaciation, increased death, etc. The economic loss is huge. For the treatment of respiratory diseases, it is generally necessary to control infection, reduce lung lesions as much as possible, and relieve fever. By controlling infection, reducing inflammation, antipyretic a...

Claims

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Application Information

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IPC IPC(8): A61K31/44A61K31/165A61K31/245A61K31/167A61K31/045A61K9/08A61P31/04A61P11/00A61P29/00
Inventor 时书宁陈瑞爱方炳虎吴广辉
Owner GUANGDONG WENS DAHUANONG BIOTECH
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