Suspension emulsion of florfenicol, preparation method and application thereof

A technology of florfenicol and suspoemulsion, which is applied in the preparation of veterinary sustained-release injections of florfenicol suspoemulsion. and other issues, to achieve the effects of good preparation stability, filling technical gaps, and good biocompatibility

Inactive Publication Date: 2009-06-03
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to technical limitations, the existing florfenicol formulations include injections, premixes, powders, etc. For the time being, there is no suspoemulsion of florfenicol on the market, and there is no relevant technical report

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1 Prepare each component according to the following ratio:

[0044] Florfenicol API 10% (W / V)

[0045] Peanut Oil 40% (W / V)

[0046] Poloxamer 1.8% (W / V)

[0047] Fatty acid glycerides 3.2% (W / V)

[0048] Add water for injection to 100% (V / V)

[0049] The preparation method is:

[0050] (1) Measure florfenicol and vegetable oil in proportion, and pass through a colloid mill to obtain an oil phase;

[0051] (2) Weigh the emulsifier and add a small amount of water for injection to stir and dissolve to obtain an aqueous phase;

[0052] (3) Add the water phase to the oil phase, pass through the colloid mill, and mix well;

[0053] (4) Add water to the full amount, stir well to obtain the suspoemulsion of Florfenicol.

Embodiment 2

[0054] Embodiment 2 Prepare each component according to the following ratio:

[0055] Florfenicol API 30% (W / V)

[0056] Peanut and Corn Oil 30% (W / V)

[0057] Fatty acid glycerides 6% (W / V)

[0058] Lecithin 10% (W / V)

[0059] Add water for injection to 100% (V / V)

[0060] The preparation method is:

[0061] (1) Measure florfenicol and vegetable oil in proportion, and pass through a colloid mill to obtain an oil phase;

[0062] (2) Weigh the emulsifier and add a small amount of water for injection to stir and dissolve to obtain an aqueous phase;

[0063] (3) Add the water phase to the oil phase, pass through the colloid mill, and mix well;

[0064] (4) Add water to the full amount, stir well to obtain the suspoemulsion of Florfenicol.

Embodiment 3

[0065] Embodiment 3 Prepare each component according to the following ratio:

[0066] Florfenicol API 25% (W / V)

[0067] Sesame oil 20% (W / V)

[0068] Gum Arabic 6% (W / V)

[0069] Poloxamer 14% (W / V)

[0070] Add water for injection to 100% (V / V)

[0071] The preparation method is:

[0072] (1) Measure florfenicol and vegetable oil in proportion, and pass through a colloid mill to obtain an oil phase;

[0073] (2) Weigh the emulsifier and add a small amount of water for injection to stir and dissolve to obtain an aqueous phase;

[0074] (3) Add the water phase to the oil phase, pass through the colloid mill, and mix well;

[0075] (4) Add water to the full amount, stir well to obtain the suspoemulsion of Florfenicol.

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PUM

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Abstract

The invention discloses a suspension emulsion of florfenicol, a preparation method and application thereof. The suspension emulsion is prepared by 10-30% (W / V) of florfenicol raw medicine, 20-40% of (W / V) of oil phase, 5-20% (W / V) of emulsifier and the balance of water; furthermore, additive can be added when necessary. The suspension emulsion of florfenicol prepared by the method has good stability, good biocompatibility, and obvious slow-release effect, can be applied to the preparation of slow-release injection of florfenicol, fills up the national technical blank, inaugurates a novel technical field for the application of florfenicol. The preparation method of the suspension emulsion is simple and feasible and has low manufacture cost.

Description

technical field [0001] The invention belongs to the technical field of veterinary antibiotics and preparation methods thereof, in particular to a suspoemulsion of florfenicol, a preparation method and the application of the florfenicol suspoemulsion in the preparation of veterinary sustained-release injections. Background technique [0002] Florfenicol (Florfenicol), also known as florfenicol, is a broad-spectrum antibacterial drug for animals developed by Schering-Plough Company in the United States in the late 1970s. It is characterized by broad antibacterial spectrum, good absorption, and wide distribution in the body , especially no potential aplastic anemia effect, no teratogenic, carcinogenic and mutagenic effects. It is clinically used as a special drug for animals and is mainly used to treat bovine respiratory diseases caused by Pasteurella and Haemophilus. Infectious diseases, such as swine contagious pleuropneumonia. [0003] Existing florfenicol dosage forms inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/165A61P31/04
Inventor 黄显会魏海涛曾振灵骆飚
Owner SOUTH CHINA AGRI UNIV
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