Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel method for synthesizing thiamphenicol and florfenicol and its key intermediate product

A synthetic method and technology of thiamphenicol, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve problems such as waste

Inactive Publication Date: 2006-03-08
SHAOXING MINSHENG PHARMA
View PDF0 Cites 21 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] As mentioned above, because the synthetic route of thiamphenicol and fluthiamphenicol involves the resolution of racemic compounds, only half of the intermediates can be used to synthesize the target compound of the desired configuration, resulting in a lot of waste

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel method for synthesizing thiamphenicol and florfenicol and its key intermediate product
  • Novel method for synthesizing thiamphenicol and florfenicol and its key intermediate product
  • Novel method for synthesizing thiamphenicol and florfenicol and its key intermediate product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] 1) Preparation of badam degreasing powder

[0060] Grind 50g of Badamia kernels in a tissue grinder, degrease with conventional organic solvents, such as 100mL of ethyl acetate, acetone or isopropyl ether, stir for 15 minutes to one hour, filter, and repeat washing 2 to 4 times to obtain The delipase powder is hydroxycyanolyase and stored in the refrigerator for later use.

[0061] After reacting sodium cyanide and glacial acetic acid, solvent extraction is used to obtain an organic solvent solution containing hydrocyanic acid, which is dried over anhydrous sodium sulfate and used; or directly adding hydrocyanic acid to an organic solvent containing 0-1% by weight of water.

Embodiment 2

[0063] 2) Synthesis of Compound 2

[0064]

[0065] Add 400mg of compound 1, 0.15g of almond degreasing powder, 5ml of 1.5eq.HCN in isopropyl ether to a 25ml egg-shaped bottle, and react at 20°C for 24 hours. Filter, wash the enzyme source powder with ethyl acetate, and combine the organic phases. Organic phase with saturated FeCl 3 Aqueous wash to FeCl 3 The solution does not change color, Na 2 SO 4 dry. Colorless crystal product, yield 90%.

[0066] [α] D 20 +50.4(c0.83, CHCl 3 ), e.e.=96%;

[0067] 1 HNMR (CDCl 3 , 300MHz): δ, 2.50(s, 3H, CH 3 ), 3.00 (br, s, 1H, OH), 5.49 (s, 1H, CH), 7.29, 7.43 (AB, J 8.5Hz, 4H) ppm;

[0068] EI-MS: m / z (rel.intensity%): 181 (M + , 2, 5), 179 (M + , 79), 162 (M + -OH, 39), 153 (M + -CN, 55), 152 (M + -HCN, 100), 151 (M + -HCN-H, 88), 132(29), 123(16), 109(20), 105(17), 91(7), 77(17);

[0069] EA: Calculation: C: 60.31%, H: 5.06%, N: 7.82%

[0070] Found values: C: 60.40%, H: 5.06%, N: 7-73%

Embodiment 3

[0072] 3) Synthesis of compound 3

[0073]

[0074] Add compound 2 (0.9g), 2-Methoxypropene (20ml), CH to 250ml egg-shaped bottle 2 Cl 2 (150ml), POCl 3 (20 mg), stirred overnight at room temperature. Join Et 3 N 3mL, stirred for 30min, stopped. The organic phase was washed with saturated brine (50ml×3), anhydrous Na 2 SO 4 dry. Flash column chromatography (EA / PE=1 / 10) gave 1.09 g of a yellow solid with a yield of 96%. Recrystallization gave 0.92 g of colorless crystals with a yield of 77%.

[0075] 1 HNMR (CDCl 3 , 300MHz): δ, 1.4(s, 3H, CH 3 ), 1.58 (s, 3H, CH 3 ), 2.50(s, 3H, SCH 3 ), 3.2(s, 3H, OCH 3 ), 5.42(s, 1H, CH), 7.25-7.41(m, 4H, Hz, Ar-H) ppm,

[0076] EI-MS: m / z (rel.intensity%): 251 (M + , 1.63), 219 (M + -H-OCH, 2.01), 179 (100.00), 162 (76.27), 151 (21.93), 132 (82.14), 109 (22.98), 105 (28.48), 86 (49.45), 45 (27.76);

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

This invention relates to a synthetic method for thiamphenicol and florfenicol and their key intermediate. Through a series of chemical reaction-first, MCPBA oxidation or deshydroxyl fluorination in advance then MCPBA oxidation, then hydrolization for ring-opening, benzyl removal and finally acetylation, the raw material No. 7 compound is ultimately converted into thiamphenicol or florfenicol. In this method, the targeted compound's chiral center is efficiently configurated and the complicated and wasted resolution process is avoied.

Description

technical field [0001] The invention relates to a new synthesis method of thiamphenicol and florfenicol and key intermediates thereof. Background technique [0002] Thiamphenicol and fluthiamphenicol are broad-spectrum antibiotics of the chloramphenicol class. The antibacterial spectrum and antibacterial effect of thiamphenicol are similar to those of chloramphenicol. Since thiamphenicol does not combine with glucuronic acid in the liver, the antibacterial activity in vivo is relatively high. Florfenicol (florfenicol) 15, also known as florfenicol, is a new type of anti-gram-positive bacteria, negative bacteria and thiamphenicol florfenicol specially developed for the animal health market Florfenicol (Florfenicol) is a broad-spectrum antibacterial drug for animals. Its structure is similar to thiamphenicol, but its antibacterial activity, antibacterial spectrum and adverse reactions are obviously superior to thiamphenicol. Its antibacterial ability can reach thiamphenicol. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C317/32C07C315/04C07D263/20
Inventor 林国强卢文芽陈沛然
Owner SHAOXING MINSHENG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com