Method for preparing solid florfenicol dispersion

A technology of solid dispersion and florfenicol, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of poor water solubility of florfenicol, troublesome clinical application, and influence Problems such as popularization and use, to achieve the effect of simple preparation process and improved solubility

Inactive Publication Date: 2012-09-12
QINGDAO LVMAN BIOLOGICAL ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the poor water solubility of florfenicol, it has brought great trouble to clinical application and affected its popularization and use.

Method used

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  • Method for preparing solid florfenicol dispersion
  • Method for preparing solid florfenicol dispersion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A kind of preparation method of florfenicol solid dispersion, carry out as follows: (every part is calculated by 10g)

[0019] (1) Take by weight 150 parts of Florfenicol (over 80 mesh sieves), 150 parts of poloxamers, and 500 parts of polyethylene glycol-4000;

[0020] (2) Heat and melt the poloxamer and polyethylene glycol-4000, stir for 3 to 5 minutes until uniform, add Florfenicol, and stir evenly;

[0021] (3) Rapidly cool the mixture obtained in (2) to -10°C, and pulverize to obtain the florfenicol solid dispersion.

Embodiment 2

[0023] A kind of preparation method of florfenicol solid dispersion, carry out as follows: (every part is calculated by 10g)

[0024] (1) Take by weight 200 parts of Florfenicol (over 80 mesh sieves), 200 parts of poloxamers, and 600 parts of polyethylene glycol-4000;

[0025] (2) Heat and melt the poloxamer and polyethylene glycol-4000, stir for 3 to 5 minutes until uniform, add Florfenicol, and stir evenly;

[0026] (3) Rapidly cool the mixture obtained in (2) to -10°C, and pulverize to obtain the florfenicol solid dispersion.

Embodiment 3

[0028] A kind of preparation method of florfenicol solid dispersion, carry out as follows: (every part is calculated by 10g)

[0029] (1) Take by weight 250 parts of Florfenicol (over 80 mesh sieves), 250 parts of poloxamers, and 700 parts of polyethylene glycol-4000;

[0030] (2) Heat and melt the poloxamer and polyethylene glycol-4000, stir for 3 to 5 minutes until uniform, add Florfenicol, and stir evenly;

[0031] (3) Rapidly cool the mixture obtained in (2) to -10°C, and pulverize to obtain the florfenicol solid dispersion.

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Abstract

The invention discloses a method for preparing solid florfenicol dispersion, and relates to the field of animal medicine. The solid florfenicol dispersion is uniformly and sequentially prepared from the following components in parts by weight: 15 to 25 parts of florfenicol (sieved with a sieve of 80 meshes), 15 to 25 parts of poloxamer, and 50 to 70 parts of polyethylene glycol-4000. The preparation method comprises the following steps of: (1) weighing 15 to 25 parts of florfenicol (sieved with the sieve of 80 meshes), 15 to 25 parts of poloxamer and 50 to 70 parts of polyethylene glycol-4000 by weight; (2) heating and melting the poloxamer and the polyethylene glycol-4000, stirring for 3 to 5 minutes till the mixture is uniform, adding the florfenicol, and stirring uniformly; and (3) quickly cooling the mixture obtained in the (2) to the temperature of 10 DEG C below zero, crushing, and thus obtaining the solid florfenicol dispersion. The preparation process is simple, and the dissolubility of the florfenicol is remarkably improved and is about 2 times that of a common florfenicol preparation (soluble powder or oral liquid).

Description

technical field [0001] The invention relates to a preparation method of a florfenicol solid dispersion, which belongs to the field of animal medicine, in particular to a preparation method of a florfenicol solid dispersion. Background technique [0002] Florfenicol is a new broad-spectrum antibacterial drug of chloramphenicol for veterinary medicine successfully developed in the late 1980s. This product is white or off-white crystalline powder, odorless, and bitter. This product is easily soluble in dimethylformamide, soluble in methanol, slightly soluble in glacial acetic acid, slightly soluble in water or chloroform. It is mainly used for bacterial diseases of pigs, chickens and fish caused by sensitive bacteria, especially for respiratory system infection and intestinal infection. [0003] Due to the poor water solubility of florfenicol, it has brought great trouble to clinical application and affected its popularization and use. Therefore developing a new technology to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/165A61K47/34A61P31/04
Inventor 周庆福刘文利
Owner QINGDAO LVMAN BIOLOGICAL ENG
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