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A technology of compound florfenicol and florfenicol, which is applied in the field of injections, can solve the problems of no research data reports and no market launch, and achieve the effects of controllable process conditions, improved antibacterial effect, and long half-life
Inactive Publication Date: 2011-04-13
JIANGXI NUCLEAR IND TIANDIHE PHARMA
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Summary
Abstract
Description
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Problems solved by technology
The data search also shows that there is no research data report on this preparation, nor is it available in the market.
Method used
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Examples
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Effect test
Embodiment 1
[0012] Example 1: Take 130ml of water, add 15g of magnesium chloride to dissolve, then add 50g of doxycycline hydrochloride (calculated as doxycycline, the same below), heat to 70-90°C to dissolve, then add florfenicol 50g, mix evenly, and set aside; add 100ml of 2-pyrrolidone and 100ml of propylene glycol to the spare solution, heat to dissolve the florfenicol, then add formaldehyde, sodium sulfoxylate and sodium metabisulfite pre-dissolved in 20ml of water to form Add 2g of mixed antioxidants, add water to make the total amount 1000ml; pass the inspection, filter, fill with nitrogen and fill with seal; sterilize at 100°C for 30 minutes.
Embodiment 2
[0013] Example 2: Take 130ml of water, add 20g of magnesium chloride to dissolve, then add 75g of doxycycline hydrochloride, heat to 70-90°C to dissolve, then add 75g of florfenicol, mix evenly, and set aside; Add 300ml of ethanol and 100ml of propylene glycol, heat to dissolve the florfenicol, then add 3g of mixed antioxidants composed of formaldehyde sodium sulfoxylate and sodium metabisulfite pre-dissolved in 20ml of water, and adjust the pH value to 6.0 with ethanolamine -9.5, add water to the full volume of 1000ml; pass the inspection, filter, fill with nitrogen and seal; sterilize at 100°C for 30 minutes.
Embodiment 3
[0014] Example 3: Take 130ml of water, add 10g of magnesium sulfate and 5g of magnesium oxide to dissolve, then add 100g of doxycycline hydrochloride, heat to 70-90°C to dissolve, then add 100g of florfenicol, and mix evenly. Standby; add 200ml of dimethylacetamide and 100ml of ethanol to the spare solution, heat to dissolve Florfenicol, then add 4g of mixed antioxidants composed of thiourea and sodium bisulfite pre-dissolved in 20ml of water, and use Adjust the pH value to 6.0-9.5 with ethanolamine, add water to the full volume of 1000ml, and pass the inspection; filter, fill with nitrogen and seal; sterilize at 100°C for 30 minutes.
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Abstract
The invention discloses compound florfenicol injection for an animal. Every 1,000ml of the compound florfenicol injection contains 50 to 300g of florfenicol, 50 to 300g of doxycycline hydrochloride, 150 to 800g of organic solvent, 5 to 90g of complexing agent and 0.2 to 1g of antioxidant. The compound florfenicol injection has the advantages that: (1) the preparation is high in complexation degree and stable in quality, and the doxycycline hydrochloride injection is instable in property; (2) the injection is low in dosage and convenient to use, and the injection twice can be finished at one time; (3) the injection greatly saves the labor cost for veterinary medicine under an intensive feeding condition; and (4) the production of the preparation is controllable in terms of technical conditions, the injection is suitable for industrial production, various raw and auxiliary materials are needed to be accurately weighed in the production process, only the reaction temperature and the reaction time are needed to be controlled without any special technical requirement, and the production technology is easy to master and control.
Description
technical field [0001] The invention relates to an injection, in particular to a veterinary compound florfenicol injection. Background technique [0002] Florfenicol is the latest generation of chlorohydrin semi-synthetic antibacterial drugs. It is widely used in the prevention and treatment of livestock and poultry diseases due to its good antibacterial effect and low toxic and side effects. One of the antibacterial drugs, Florfenicol Injection is mainly used to prevent and treat gastrointestinal infections caused by colibacillosis, salmonellosis, pasteurellosis, etc. in livestock and poultry. Doxycycline hydrochloride is the latest generation of semi-synthetic antibacterial drugs of the tetracycline class. As an important control drug for livestock and poultry, its antibacterial and antiprotozoal effects are 4-8 times that of oxytetracycline. It is usually added to feed or made into Injection, due to its excellent effect, its global veterinary dosage ranks in the forefro...
Claims
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Application Information
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