29 results about "Oxazolidine E" patented technology

The invention belongs to the technical field of electrolyte, and particularly relates to electrolyte and a secondary battery. The electrolyte comprises a water-removing and acid-inhibiting additive, the mass percent of the water-removing and acid-inhibiting additive is 0.05%-2.2% by taking the total mass of the electrolyte as 100%, the water-removing and acid-inhibiting additive comprises compounds with structures shown in a formula II and a formula III, the compound with the structure shown in the formula II is 3-ethyl-2-methyl-2-(3-methylbutyl)-1, 3-oxazolidine, and the compound with the structure shown in the formula III is 3-ethyl-2-methyl-2-(3-methylbutyl)-1, 3-oxazolidine. The compound with the structure as shown in the formula III is 3-butyl-2-(1-ethyl amyl)-1, 3-oxazolidine. The mass ratio of the compound with the structure shown in the formula II to the compound with the structure shown in the formula III is (1: 2)-(1: 4). The formula II and the formula III are compounded according to the proportion of (1: 2)-(1: 4), the overall performance of the additive can be synergistically optimized, the formula II provides rapid initial acid inhibition response, and the formula III ensures lasting later protection, so that the long-acting period from formation to long-term circulation of the battery is covered.

The invention discloses a benzoxphosphine ligand and a complex and application thereof. The structure of the benzoxphosphine ligand is shown as a formula (I), in the formula (I), R1 is alkyl or aryl substituted oxazolidinyl or imidazoline, R2 is alkyl and / or aryl, and R3 is at least one of fluorine, carbazolyl and 2, 6-dimethoxyphenyl. According to the benzoxphosphine ligand disclosed by the invention, the metal iridium complex can be used as a catalyst to be applied to an asymmetric hydrogenation reaction of alpha-phenyl vinyl diethyl phosphate, and has excellent activity and relatively high enantioselectivity; moreover, the benzoxphosphine ligand disclosed by the invention can be directly synthesized from simple and easily available chiral aldehyde, and the preparation method is simple and easy to operate.

The invention discloses a preparation method of an azacyclo-bis (fluorosulfonyl) imide salt derivative, which comprises the following steps of: 1, mixing an azacyclo-compound, a methylation reagent, an ethylation reagent, bis (fluorosulfonyl) imide salt and inorganic alkali in a polar organic solvent, heating, and filtering after complete reaction to obtain crude filtrate containing the azacyclo-bis (fluorosulfonyl) imide salt; the nitrogen heterocyclic compound is selected from one of oxazolidine, 4-cyano piperidine, 4-fluoro piperidine, 4, 4-difluoro piperidine and 3-cyano piperidine; the bis (fluorosulfonyl) imide salt is selected from one of lithium bis (fluorosulfonyl) imide and potassium bis (fluorosulfonyl) imide; and 2, adding an inert organic solvent into the crude product filtrate for crystallization, and performing vacuum drying to obtain a finished product. The method has the advantages that the operation steps are few, the synthesis efficiency is greatly high, the process is greatly simplified, and the preparation cost is effectively reduced.

The invention relates to the technical field of shoe materials, in particular to shoe material sponge applied to shoes easy to wear and take off and a preparation method of the shoe material sponge. The shoe material sponge is prepared from the following raw materials in parts by weight: 70 to 80 parts of polyether polyol, 10 to 17 parts of polyester polyol, 3 to 8 parts of a chain extender, 5 to 12 parts of thiolated nano silicon dioxide, 0.3 to 0.8 part of a Grubbs catalyst, 3 to 10 parts of self-repairing microcapsules, 1 to 3 parts of an oxazolidine crosslinking agent, 1 to 2.5 parts of a foaming agent, 0.05 to 0.2 part of a catalyst, 1 to 2 parts of a foam stabilizer and 40 to 60 parts of isocyanate. The core material of the self-repairing microcapsule is dicyclopentadiene; the method has the advantage that the fatigue resistance of the sponge for the shoe material is improved.

The present invention relates to compounds of formula (I) as properfume compounds. In particular, the present invention relates to a method to release an aldehyde or a ketone of formula (II), by exposing the compound of formula (I) to a trace of water. Moreover, the present invention relates to a perfuming composition and a perfumed consumer product comprising at least one compound of formula (I).

The present disclosure provides compositions of (4R,5R)-5-(2-chlorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one (Compound 1). Crystal and solvate forms of the compound are also provided, as well as formulations comprising the compound. Methods of using the compounds and administering formulations to a subject in need thereof to treat or prevent CNS disorders, such as Alzheimer's disease, are provided.

The present invention relates to novel cyclic compounds; a method for the solid phase synthesis of said novel cyclic compounds; novel thiazolidine and oxazolidine building blocks that can be directly incorporated into the solid phase synthesis of said novel cyclic compounds, and a novel method for the synthesis of said thiazolidine and oxazolidine building blocks; and cosmetic compositions containing said novel cyclic compounds.

The present invention discloses oxazolidinone compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A and E, are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of an oxazolidinone of the invention and / or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and / or salt.

The invention discloses a synthesis method of (4S, 5R)-3-[2-[[fluorenylmethoxycarbonyl] amino] acetyl]-2, 2, 5-trimethyl-4-oxazolidine carboxylic acid, which comprises the following steps: S1, carrying out amino protection reaction on L-threonine methyl ester hydrochloride to form a compound I; s2, reacting the compound I with Lewis acid and a cyclization reactant to generate a compound II; s3, performing ammonolysis on the compound II to obtain a compound III; s4, carrying out hydrolysis reaction on the compound III and an alkali reagent to obtain a compound IV; and S5, reacting the compound IV with an fmoc protection reagent to obtain a final product (4S, 5R)-3-[2-[[fluorenylmethoxycarbonyl] amino] acetyl]-2, 2, 5-trimethyl-4-oxazolidine carboxylic acid. The method is high in yield and purity and low in cost.

The invention provides a novel carrier-free catalysis strategy, the in-situ carboxylation cyclization reaction of ultralow-concentration carbon dioxide and propargylamine is realized by utilizing low-cost silver carbonate under the conditions of normal temperature and normal pressure, and the oxazolidinone compound with important industrial value is efficiently synthesized. The catalytic system not only can efficiently convert carbon dioxide in a low concentration range of 5 vol.% to 35 vol.%, but also can directly convert carbon dioxide as low as 0.04 vol.% in air to generate oxazolidinone, the highest yield can reach 97%, and good substrate applicability is shown. By constructing a circular reaction device, the concentration of carbon dioxide in simulated gas can be reduced from 15 vol.% to 3 vol.%, and meanwhile, the average yield of oxazolidinone is maintained to reach 92%.

Crystalline polymorph forms of(S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino) propanamide (GDC-0077), having the structure, Formula I:or stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, processes of preparing the polymorph forms, and uses of the polymorph forms for the treatment of cancer.

The application provides a method for synthesizing oxazolidinone compounds based on carbon dioxide and alcohol amine, a catalyst, oxazolidinone compounds prepared based on carbon dioxide and alcohol amine, and application of cerium-based composite oxides in preparation of oxazolidinone compounds based on carbon dioxide and alcohol amine. The method comprises the following steps: taking carbon dioxide and alcohol amine as raw materials, and allowing the alcohol amine to react with the carbon dioxide under the action of a solid catalyst to generate the oxazolidinone compounds; wherein the solid catalyst comprises cerium-based composite oxides, and the reaction process comprises liquid-phase carboxylation and cyclization dehydration. The method provided by the application can easily separate the catalyst from the product, and can make the alcohol amine have a high conversion rate.

The present disclosure provides methods of treating Alzheimer's disease and other disorders using (4R,5R)-5-(2-chlorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one (Compound 1).

This invention provides a method for synthesizing 3-cinnamyl oxazolidine-2-one derivatives. The method provided by this invention is a one-step synthesis of 3-cinnamyl oxazolidine-2-one derivatives. Compared with commonly used methods, it requires only one step to obtain the product and requires less catalyst, thus enabling a more efficient and environmentally friendly method to obtain the corresponding product.

The invention discloses insulating oil and a preparation method thereof. The insulating oil comprises base oil and a water removal agent, and the water removal agent comprises at least one of an isocyanate water removal agent, a silane water removal agent, an oxazolidine water removal agent, an ester water removal agent and a nitrile water removal agent. The insulating oil provided by the invention is low in moisture content, long in service life and high in insulating property.

The present invention discloses a urea compound, 1-(4-hydroxycyclohexyl)-3-(3-(2-oxoxazolidin-3-yl)phenyl)urea, for inducing an antigen-specific reaction, as shown in Formula 1; a fluorescent marker thereof, and a preparation method and use thereof. The invention relates to the fields of medicinal chemistry and pharmacotherapy. The preparation method comprises the following steps: dissolving 2-oxazolidinone, N,N-dimethylglycine, cuprous iodide, and potassium carbonate in a solvent, and reacting them with 3-bromoaniline to produce intermediate I; dissolving intermediate I, and reacting it with triethylamine and phenyl chloroformate to produce intermediate II; and reacting intermediate II with 4-aminocyclohexane-1-ol hydrochloride and N,N-diisopropylethylamine (DIPEA) to produce a product. The aforementioned small molecule compound has the characteristics of small molecular weight, easy binding to CD91, and rapid entry into DC cells. #imgabs0#

The application discloses a high-reliability aluminum electrolytic capacitor and a preparation method thereof. The aluminum electrolytic capacitor comprises a core package and an electrolyte immersed in the core package. The electrolyte comprises, in terms of mass parts, 30-50 parts of an organic solvent, 10-20 parts of a composite lithium salt, 5-15 parts of an additive, and 0.05-0.15 parts of an electrolyte. The additive comprises 0.01-0.1 parts of oxazolidine and 0.48-0.51 parts of polyethylene glycol dimethyl ether. The application optimizes the electrolyte formula, introduces oxazolidine and polyethylene glycol dimethyl ether as key additives, and cooperates with the composite lithium salt, the organic solvent and the electrolyte, thereby significantly improving the anti-vibration performance and high-temperature load performance of the aluminum electrolytic capacitor. After the vibration test, the capacitance change rate can be controlled within ±0.2%. After the high-temperature load test, the capacitance attenuation amplitude is small, and the DF value and ESR remain stable. The application is particularly suitable for application scenarios with strict reliability requirements and has a wide market application prospect.

The invention relates to the technical field of photocuring monomers, in particular to an anti-oxidation polymerization inhibition UV (ultraviolet) photocuring urethane type monomer, which is prepared from the following components in parts by mass: 1 part of hydroxyl-containing monomer, 1 to 3 parts of terminated monomer, 1 to 3 parts of diisocyanate, 300ppm of polymerization inhibitor and 300ppm of catalyst, the monomer containing the hydroxyl is oxygen heterocyclic ketone containing the hydroxyl or oxazolidinone containing the hydroxyl; the preparation method comprises the following steps: adding a catalyst and a polymerization inhibitor into diisocyanate, uniformly mixing, controlling the reaction temperature not to exceed 45 DEG C, dropwise adding an end-capping monomer, titrating to monitor the reaction, and finishing the first-stage reaction when the NCO reaction amount reaches 50-55% of the initial numerical value; and adding a hydroxyl-containing monomer into the reaction liquid in the first stage, and finishing the reaction when the content of NCO in the system is monitored to be less than 0.1%. According to the preparation method disclosed by the invention, oxygen heterocyclic ketone or an alcohol substance containing oxazolidinone is subjected to ring-opening reaction in a photocuring process to serve as an active H donor to quickly react with peroxy free radicals, so that active free radicals are effectively regenerated, and anti-oxygen polymerization inhibition is realized.

The present application relates to a kind of 2-oxazolidinone-3-carbamimidate-5-methylene derivatives and preparation method thereof, belong to organic synthesis technical field.The structure of 2-oxazolidinone-3-carbamimidate-5-methylene derivatives provided in the present application is as shown in formula (I)-(III).2-Oxazolidinone-3-carbamimidate-5-methylene derivatives of the present application can be applied to the synthesis and activity screening of novel oxazolidinone antibiotics, can provide technical support for the further derivatization and biological activity research of 2-oxazolidinone-3-carbamimidate derivative compound, with wide application prospect.

The present invention discloses a preparation method of a sacubitril intermediate, belonging to the field of pharmaceutical manufacturing. (R)-4-(Hydroxymethyl)oxazolidin-2-one reacts with sulfonyl chloride to generate (S)-(2-oxooxazolidin-4-yl)methyl 4-methylbenzenesulfonate, and the product then reacts with a Grignard reagent to obtain (R)-(2-oxooxazolidin-4-yl)methylbiphenyl, which is then hydrolyzed and BOC is introduced onto the amino group to obtain D-N-BOC-biphenylpropanol. This preparation method has a short route, mild reaction conditions, simple process operation, and is suitable for industrial production.

The invention discloses (R)-4-isopropyl-3-((R)-2-methyl-5-hexenoyl) oxazolidine-2-ketone and application of the (R)-4-isopropyl-3-((R)-2-methyl-5-hexenoyl) oxazolidine-2-ketone to synthesis of sex pheromone components of western inchworm cedar, and relates to the technical field of biological pesticides. According to the application, (R)-4-isopropyl-3-((R)-2-methyl-5-hexenoyl) oxazolidine-2-ketone is utilized to synthesize (5R, 11S)-5, 11-dimethyl heptadecane, the total yield can reach 18%, and the optical purity of (5R, 11S)-5, 11-dimethyl heptadecane is greater than 99%; the (S)-7-methylheptadecane is synthesized by using the (R)-4-isopropyl-3-((R)-2-methyl-5-hexenoyl) oxazolidine-2-ketone, the total yield can reach 30%, and the optical purity of the (5R, 11S)-5, 11-dimethylheptadecane is greater than 99%.

The present invention relates to a preparation method and application of a cerium oxide (CeO2)-supported copper (Cu)-based catalyst, in which Cu is supported on the CeO2 surface in the form of a combination of Cu single atoms and Cu nanoparticles, a combination of Cu single atoms in mixed valence states, or a combination of Cu mixed oxides. The catalyst can be used to prepare three different high-value-added chemicals and derivatives: cyclic carbonates, oxazolidinones, and α-hydroxyketones, using carbon dioxide (CO2) as a raw material.

The invention provides a method and a catalyst for synthesizing an oxazolidinone compound based on carbon dioxide and alcohol amine, the oxazolidinone compound prepared based on carbon dioxide and alcohol amine, and application of a cerium-based composite oxide in preparation of the oxazolidinone compound based on carbon dioxide and alcohol amine. The method comprises the following steps: taking carbon dioxide and alkylol amine as raw materials, and reacting the alkylol amine with the carbon dioxide under the action of a solid catalyst to generate the oxazolidinone compound, wherein the solid catalyst comprises a cerium-based composite oxide, and the reaction process comprises liquid-phase carboxylation and cyclization dehydration. According to the method provided by the invention, the catalyst can be easily separated from the product, and the reactant alcohol amine has a relatively high conversion rate.

The present invention relates to the technical field of matte films, and discloses a preparation process of a matte PE film for cotton soft towel packaging, including: using dibutyl phosphite, 2-(oxazolidin-3-yl)ethanol, and di(hydrogenated tallow-based) phthalic acid amide as raw materials to synthesize a tetra-long-chain alkylated dibutyl phosphate monomer, modifying it on the surface of SiO2 by covalent grafting method to obtain a solvent-free nano-SiO2 fluid with a core-shell structure; filling the solvent-free nano-SiO2 fluid into a mixed resin matrix of polyethylene and polypropylene, mixing to form a homogeneous system, and preparing a matte masterbatch; using the matte masterbatch as the outer layer raw material, high-density polyethylene resin as the intermediate layer raw material, and metallocene polyethylene resin as the inner layer raw material, and adopting a three-layer co-extrusion blow molding process to prepare a matte PE film for cotton soft towel packaging. The matte PE film developed by the present invention exhibits very excellent matte performance while only slightly decreasing in tear resistance.

The application belongs to the technical field of electrolyte, and particularly relates to an electrolyte and a secondary battery. The electrolyte comprises a water removal and acid suppression additive, and the mass percentage of the water removal and acid suppression additive is 0.05% to 2.2% based on 100% of the total mass of the electrolyte. The water removal and acid suppression additive comprises a compound with a structure shown in Formula II and a compound with a structure shown in Formula III. The compound with the structure shown in Formula II is 3-ethyl-2-methyl-2-(3-methylbutyl)-1,3-oxazolidine, and the compound with the structure shown in Formula III is 3-butyl-2-(1-ethylpentyl)-1,3-oxazolidine. The mass ratio of the compound with the structure shown in Formula II to the compound with the structure shown in Formula III is (1:2) to (1:4). The compound with the structure shown in Formula II and the compound with the structure shown in Formula III are compounded in a ratio of (1:2) to (1:4), so that the overall performance of the additive can be synergistically optimized. The compound with the structure shown in Formula II provides a rapid initial acid suppression response, and the compound with the structure shown in Formula III ensures long-term protection, so that a long-term cycle from formation to long-term cycle of the battery is covered.

The present invention discloses a synthesis method and application of 2-oxazolidinone derivatives, belonging to the technical field of organic synthesis. Starting from the p-quinone monoimine shown in Formula Ι and with the action of a specific acid catalyst, 2-oxazolidinone compounds with diverse structures shown in Formula Ⅱ can be obtained. This synthesis method is simple, environmentally friendly, has a wide substrate scope, is convenient for purification and has a high yield. At the same time, the compound shown in Formula Ⅱ obtained in the present invention exhibits certain anti-tumor effects and has development prospects in the field of anti-tumor drug preparation.

The present disclosure relates to methods for treating bronchiectasis, for example, non-cystic fibrosis bronchiectasis with compositions comprising an effective amount of certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds of Formula (I), including pharmaceutically acceptable salts thereof,that inhibit dipeptidyl peptidase 1 (DPP1) activity. Methods provided herein are useful for prophylaxis, increasing the lung function in a patient, and / or decreasing the rate of pulmonary exacerbation in a patient. In one embodiment, the compound of Formula (I) is (2S)-N-{(1S)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide.

The application discloses a kind of ( R )‑4‑isopropyl‑3‑(( R )‑2‑methyl‑5‑hexenoyl) oxazolidine‑2‑ketone and application in synthesis western hemlock looper sex pheromone component, it relates to the technical field of biological pesticide.The application utilizes ( R )‑4‑isopropyl‑3‑(( R )‑2‑methyl‑5‑hexenoyl) oxazolidine‑2‑ketone synthesis (5 R ,11 S )‑5,11‑dimethyl heptadecane, total yield can reach 18%, and (5 R ,11 S )‑5,11‑dimethyl heptadecane optical purity is greater than 99%;The application utilizes ( R )‑4‑isopropyl‑3‑(( R )‑2‑methyl‑5‑hexenoyl) oxazolidine‑2‑ketone synthesis ( S )‑7‑methyl heptadecane, total yield can reach 30%, and (5 R ,11 S )‑5,11‑dimethyl heptadecane optical purity is greater than 99%.

The application discloses a kind of di-substituted phosphite and 2-(oxazolidine-3-yl)ethanol derivatives, and preparation method and application thereof.The core step of the method involves mixing catalyst with 2-(oxazolidine-3-yl)ethanol, then gradually adding phosphite compound within the reaction temperature range of 65-70℃, after dropwise addition is completed, the system is reacted at 65-70℃ for 1-10 hours, by adding appropriate amount of propylene oxide to neutralize the acid produced in the reaction until the acid value is reduced to below 5mgKOH / g, so as to ensure the chemical stability of the product;The reaction mixture is distilled under reduced pressure to remove unreacted raw materials and low-boiling impurities, and further purified by fine filtration to obtain high-quality di-substituted phosphite and 2-(oxazolidine-3-yl)ethanol derivative flame retardant.The preparation method of the application not only has simple and clear process design, simple and fast operation process, but also has mild reaction condition, can be efficiently completed without extreme condition, and the catalyst used can be repeatedly used.