Method for preparing oxazolidinone compound and intermediate thereof

One compound and one technology, applied in the field of pharmaceutical chemical synthesis, can solve problems such as unsuitable for industrial production, many side reactions, and low purity
CN104496979AInactive Publication Date: 2015-04-08BRIGHTGENE BIO MEDICAL TECH (SUZHOU) CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BRIGHTGENE BIO MEDICAL TECH (SUZHOU) CO LTD
Publication Date
2015-04-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for preparing an oxazolidinone compound and an intermediate thereof. Specifically, two fragments are coupled to prepare the oxazolidinone compound by virtue of Suzuki reaction. The method is simple in process, short in reaction time and high in yield and is suitable for industrial production. Furthermore, the method for preparing the intermediate of the oxazolidinone compound has the advantages of simplicity in operation, high yield and low cost.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical chemical synthesis, in particular to a preparation method of oxazolidinone compounds and intermediates thereof. Background technique

[0002] Oxazolidinones as a class of chemical constituents find wide application in drugs for the treatment and prevention of medical diseases such as bacterial infections and atherosclerosis. Various structures of oxazolidinone derivatives are known. For example, US4461773, US4476136, US4250318 and the like disclose mono-substituted or di-substituted derivatives of 3-phenyl-2-oxazolidinone.

[0003] Tedizolid (Tedizolid) is a new type of oxazolidinone antibiotics, its phosphate (tedizolid phosphate) has been approved by the FDA for the treatment of Staphylococcus aureus (including methicillin-resistant strains, methicillin-sensitive strains) and acute bacterial skin and skin structure infections (ABSSSI) caused by Gram-positive bacteria such as various Streptococcus...

Claims

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