Method for producing florfenicol soluble powder

A technology of florfenicol and a production method, which is applied in the production field of florfenicol soluble powder, can solve problems such as low production efficiency, insufficient solubility, limited dosing route and the like, and achieves the effects of large output and high production efficiency

Inactive Publication Date: 2011-02-09
WUXI ZHENGDA POULTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the original powder of Florfenicol is a kind of medicine which is insoluble in water but only soluble in some organic solvents, so its route of administration is greatly restricted.
At present, some manufacturers mix fl

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] (1) First mix and dissolve 3kg 2-hydroxypropyl-β cyclodextrin and 9kg water, then dissolve 7kg florfenicol into 0.7kg dimethylformamide, put the two solutions into a grinder for mixing and grinding , and the time is 2 hours.

[0014] (2) Spray-dry the above clathrated solution with a spray-drying tower with an inlet air temperature of 140°C, an outlet air temperature of 80°C, and an inlet air pressure of 25Mpa to obtain the final product.

Embodiment 2

[0016] (1) First mix and dissolve 3kg of 2-hydroxypropyl-β cyclodextrin and 12kg of water, then dissolve 7kg of florfenicol into 1kg of dimethylformamide, and put the two solutions into a grinder for mixing and grinding. for 3.5 hours.

[0017] (2) Spray-dry the above clathrated solution with a spray drying tower: the air inlet temperature of the spray drying tower is 145°C, the outlet air temperature is 100°C, and the air inlet pressure is 30Mpa to obtain the final product.

Embodiment 3

[0019] (1) Mix and dissolve 3kg 2-hydroxypropyl-β cyclodextrin and 15kg water first, then dissolve 7kg florfenicol into 1.4kg dimethylformamide, put the two solutions into a grinder for mixing and grinding , the time is 5 hours.

[0020] (2) Spray-dry the above clathrated solution with a spray drying tower: the inlet air temperature of the spray drying tower is 150°C, the outlet air temperature is 110°C, and the inlet air pressure is 35Mpa to obtain the final product.

[0021] The invention combines the grinding clathrate and the spray drying process, so the production efficiency is high and the output is large. Experiments have shown that the solubility of the florfenicol inclusion powder prepared by the inventive method is increased to 263mg / ml (easy to dissolve) from the original 13mg / ml (slightly soluble), and the solubility has been enlarged by 20 times, and the product can be directly dissolved in water Give animals to drink and cure diseases.

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PUM

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Abstract

The invention relates to a method for producing florfenicol soluble powder. The method comprises the following technical steps of: 1, including florfenicol and 2-hydroxypropyl-beta-cyclodextrin; and 2, performing spray drying on included solution by a spray drying tower. By combining grinding inclusion and spray drying process, the production efficiency and the yield are high; the solubility of the prepared florfenicol-included powder is increased to be 263mg/ml (soluble) from original 13mg/ml (slight soluble) and enlarged by 20 times; and the product can be directly dissolved in water and diseases of animals can be treated by drinking the water.

Description

technical field [0001] The invention relates to the technical field of feed and feed additives, in particular to a production method of florfenicol soluble powder. Background technique [0002] Florfenicol is also known as fluprofen and flumethenone. The system name is [R--(R1.T)]-2,2-dichloro-N-{fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl} acetamide. This product is a veterinary antibacterial drug, which is used for the bacterial diseases of pigs, chickens and fish caused by sensitive bacteria, especially for respiratory system infection and intestinal infection. However, the original powder of Florfenicol is a kind of medicine which is insoluble in water but only soluble in some organic solvents, so its route of administration is very limited. At present, some manufacturers mix florfenicol and cyclodextrin to improve its solubility, but the existing process still has the defects of insufficient product solubility and low production efficiency, which cannot...

Claims

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Application Information

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IPC IPC(8): A61K47/48A23K1/17A61K31/165A61P31/04A23K20/195A61K47/61
Inventor 周玲
Owner WUXI ZHENGDA POULTRY
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