Use of eucalyptus oil formulations in the treatment of skin inflammation

Abstract

The application discloses application of eucalyptus oil preparation in skin inflammation treatment, the dosage form of the eucalyptus oil preparation is one of cream, ointment, liniment, spirit, mud film, spray and dressing, the eucalyptus oil preparation contains eucalyptol, the content of the eucalyptol is 1% or 2.5%, when the dosage form of the eucalyptus oil preparation is cream, different potency glucocorticoids are additionally added in the eucalyptus oil preparation to form a compound preparation, when the dosage form of the eucalyptus oil preparation is liniment, glycerol is added in the eucalyptus oil preparation, when the dosage form of the eucalyptus oil preparation is mud film, the mud film is mud-like facial mask prepared by mud film powder and eucalyptus oil.The several new dosage forms provided by the application have the advantages of convenient storage, easy carrying and convenient use under the premise of ensuring treatment effect, and the mud film preparation is extremely friendly to female skin inflammation patients.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical technology, specifically to the application of eucalyptus oil preparations in the treatment of skin inflammation. Background Technology

[0002] Eucalyptus oil is a volatile oil extracted by steam distillation from plants of the same genus, such as *Eucalyptus globulus* (family Myrtaceae) or *Cinnamomum camphora* (family Lauraceae). It is a colorless or slightly yellow clear liquid with a distinctive aromatic odor. Its main components are eucalyptol, pinene, camphene, limonene, and terpineol. The eucalyptol content is typically 70%–85%. Its main functions are to relieve wind and pain, and it is suitable for alleviating symptoms of itchy skin and neuralgia. Eucalyptus oil also has inhibitory effects on various bacteria, such as *Staphylococcus aureus*, and is widely used in medicine, chemicals, agriculture, and skincare products.

[0003] In previous studies, the inventors discovered that a compound preparation made from eucalyptus oil combined with the glucocorticoid betamethasone has a good effect in treating skin inflammations such as dermatitis and eczema. Based on this, the inventors applied for an invention patent with patent number 2019106653004 and patent name: A compound preparation of eucalyptol combined with glucocorticoids with anti-inflammatory and skin barrier protective effects. In the specification of the patent, the inventors described the mechanism of action of the compound preparation and the experimental results at the cellular level. The eucalyptol monotherapy preparation has been registered for clinical trials (registration number: ChiCTR1900020865) and randomized controlled trials have been carried out in clinical trials.

[0004] The inventors have accumulated sufficient experimental data in the aforementioned work, and the existing data can prove that both eucalyptol monotherapy and combination formulations with glucocorticoids have good efficacy in the treatment of skin inflammation. How to transform eucalyptol preparations from theoretically feasible to easy-to-use products in clinical or daily life while still maintaining good therapeutic effects is a pressing technical problem that needs to be solved. Summary of the Invention

[0005] Therefore, this invention discloses the application of eucalyptus oil preparations in the treatment of dermatitis and eczema, and provides a variety of new dosage forms of eucalyptus oil products. The new dosage forms provided have the advantages of convenient storage, easy portability and convenient use while ensuring therapeutic effect. Moreover, the mud mask preparation is extremely friendly to female patients with skin inflammation.

[0006] To achieve the above-mentioned technical effects, the present invention is implemented through the following technical solution: The application of eucalyptus oil preparations in the treatment of skin inflammation, wherein the dosage form of the eucalyptus oil preparation is one of creams, ointments, liniments, liniments, mud masks, sprays, and dressings.

[0007] Furthermore, the eucalyptus oil preparation contains eucalyptol, and the eucalyptol content is 1% or 2.5%.

[0008] Furthermore, when the eucalyptus oil preparation is in the form of a cream or ointment, different potencies and concentrations of glucocorticoids are added to the eucalyptus oil preparation to form eucalyptus oil compound preparations suitable for different usage scenarios.

[0009] Furthermore, when the eucalyptus oil preparation is in the form of a liniment, glycerin is added to the eucalyptus oil preparation.

[0010] Furthermore, when the eucalyptus oil preparation is in the form of a tincture, alcohol is added to the eucalyptus oil preparation.

[0011] Furthermore, when the dosage form of the eucalyptus oil preparation is a mud film, the mud film is a mud-like face mask made of mud film powder and eucalyptus oil.

[0012] The beneficial effects of this invention are as follows: This invention provides a variety of new dosage forms of eucalyptus oil products, and the provided new dosage forms have the advantages of convenient storage, easy portability and convenient use while ensuring therapeutic effects. Moreover, the mud mask preparation is extremely friendly to female patients with skin inflammation. Attached Figure Description

[0013] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0014] Figure 1 This is a picture of a eucalyptus oil preparation in the form of an ointment; Figure 2 This is a picture of a eucalyptus oil preparation used as a liniment. Figure 3 This is a picture of a eucalyptus oil preparation used as a mud film. Figure 4 This is a comparison chart of the effects of using the eucalyptus oil preparation as a cream in Case 1 in the examples; Figure 5 This is a comparison chart of the effects of using the eucalyptus oil preparation as a cream in Case 2 in the examples; Figure 6 This is a comparison chart of the effects of using the eucalyptus oil preparation as a cream in Case 3 in the examples; Figure 7 This is a comparison chart of the effects of using the eucalyptus oil preparation as a cream in Case 4 in the examples; Figure 8 This is a comparison chart of the effects of using the eucalyptus oil preparation as a cream in Case 5 in the examples; Figure 9 This is a comparison chart of the effects of using the eucalyptus oil preparation as a cream in Case 6 in the examples; Detailed Implementation

[0015] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0016] This invention discloses the application of eucalyptus oil preparations in the treatment of skin inflammation, wherein the dosage form of the eucalyptus oil preparations is one of creams, ointments, liniments, liniments, mud masks, sprays, and dressings.

[0017] In this embodiment, the eucalyptus oil preparation contains eucalyptol, and the content of eucalyptol is 1% or 2.5%.

[0018] In this embodiment, when the eucalyptus oil preparation is in the form of a cream or ointment, glucocorticoids of different potencies and concentrations are added to the eucalyptus oil preparation, with betamethasone being the preferred glucocorticoid.

[0019] In this embodiment, when the eucalyptus oil preparation is in the form of a liniment, glycerin is added to the eucalyptus oil preparation.

[0020] In this embodiment, when the eucalyptus oil preparation is in the form of a medicated paste, alcohol is added to the eucalyptus oil preparation.

[0021] In this embodiment, when the dosage form of the eucalyptus oil preparation is a mud film, the mud film is a mud-like face mask made of mud film powder and eucalyptus oil.

[0022] Clinical Cases: The following clinical cases are used to verify the clinical efficacy of several novel formulations provided by this invention: Case 1: Mr. Zhou, male, 37 years old, presented on April 11, 2025. Symptoms: Microscopic examination revealed hyperkeratosis of the skin tissue with follicular plugging, focal parakeratosis, acanthosis, focal interspinous edema, thickened basement membrane, scattered liquefactive degeneration of basal cells, loose and edematous collagen around blood vessels in the superficial dermis, and scattered inflammatory cell clusters, mainly lymphocytes, around blood vessels and sebaceous glands, with occasional plasma cells and eosinophils. Pathological diagnosis: discoid lupus erythematosus, steroid-dependent dermatitis. Treatment: Oral + topical medication, with topical application of the eucalyptus oil cream prepared in this invention, applied once daily. Treatment effect: After 2 weeks of treatment, as... Figure 4 As shown, the patient's erythema area decreased, the spot size shrank, and the degree of redness and swelling lessened.

[0023] Case 2: Mr. Huang, male, 29 years old, presented on May 30, 2025. Symptoms: squamous epithelial hyperplasia and thickening of the mucosa, acanthosis, mild edema of the superficial dermis, telangiectasia, and scattered perivascular inflammatory infiltration dominated by lymphocytes, with occasional eosinophils. Pathological diagnosis: exfoliative cheilitis, glandular cheilitis. Treatment: oral and topical application of the eucalyptus oil cream prepared in this invention, applied once daily. Treatment effect: After 6 weeks of treatment, if... Figure 5 As shown, the patient's lip inflammation has lessened, the edema has disappeared, and the lips have regained their rosy luster.

[0024] Case 3: Ms. Ai, 38 years old, presented on March 26, 2025. Chief complaint: recurrent dryness and burning sensation on the face for over 3 months, facial desquamation, poorly defined erythema, and papules. Pathological diagnosis: steroid-dependent dermatitis. Treatment: oral and topical medication, with topical application of the eucalyptus oil cream prepared in this invention, applied once daily. Treatment effect: After 2 weeks of treatment, as... Figure 6 As shown, the burning sensation disappeared, the dandruff disappeared, and the facial erythema disappeared.

[0025] Case 4: Ms. Yang, 45 years old, pathological diagnosis: hormone-dependent dermatitis, treatment: oral + topical, topical application of the eucalyptus oil cream prepared in this invention, applied once daily; treatment effect: after 3 weeks of treatment, as... Figure 7 As shown, the area of ​​erythema decreased and the degree of redness and swelling lessened.

[0026] Case 5: Ms. Li, 46 years old, clinical diagnosis: generalized eczema of the lower extremities, autosensitization eczema; treatment: oral + topical, topical application of the eucalyptus oil lotion prepared in this invention, applied once daily; treatment effect: as... Figure 8 As shown, the dandruff disappeared and the area of ​​eczema shrank.

[0027] Case 6: Ms. Zhuang, chief complaint: recurrent itching and oozing in the left lower extremity for 2 months, tentative diagnosis: subacute eczema of the lower leg; treatment: topical application of the eucalyptus oil liniment prepared in this invention, applied once daily; treatment effect: as described above. Figure 9 As shown, itching was reduced, the area of ​​skin lesions decreased, and the severity of skin lesions lessened.

[0028] The novel mud mask formulation of this invention has been used in the facial care room of our hospital. Based on the patients' facial tightness, itching and other barrier damage symptoms, it has cured or soothed facial hormone-dependent dermatitis, rosacea, seborrheic dermatitis and other conditions.

[0029] In the description of this specification, references to terms such as "an embodiment," "example," and "specific example" indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

Claims

1. The application of eucalyptus oil preparations in the treatment of skin inflammation, characterized in that, The dosage form of the eucalyptus oil preparation is one of the following: cream, ointment, liniment, liniment, mud mask, spray, and dressing.

2. The application of the eucalyptus oil preparation according to claim 1 in the treatment of skin inflammation, characterized in that, The eucalyptus oil preparation contains eucalyptol, and the content of eucalyptol is 1% or 2.5%.

3. The application of the eucalyptus oil preparation according to claim 2 in the treatment of skin inflammation, characterized in that, When the eucalyptus oil preparation is in the form of a cream or ointment, different potencies and concentrations of glucocorticoids are added to the eucalyptus oil preparation to form eucalyptus oil compound preparations suitable for different usage scenarios.

4. The application of the eucalyptus oil preparation according to claim 2 in the treatment of skin inflammation, characterized in that, When the eucalyptus oil preparation is in the form of a liniment, glycerin is added to the eucalyptus oil preparation.

5. The application of the eucalyptus oil preparation according to claim 2 in the treatment of skin inflammation, characterized in that, When the eucalyptus oil preparation is in the form of a tincture, alcohol is added to the eucalyptus oil preparation.

6. The application of the eucalyptus oil preparation according to claim 2 in the treatment of skin inflammation, characterized in that, When the eucalyptus oil preparation is in the form of a mud film, the mud film is a mud-like face mask made of mud film powder and eucalyptus oil.

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