Silibinin oral disintegration tablet and its preparing method

Abstract

The present invention relates to one kind of orally disintegrated silibinin tablet for protecting liver cell, stimulating the biological synthesis of protein inside liver cell, promoting recovery of damaged liver cell, resisting fibrillation, capturing free oxygen radical and inhibiting the deposition and infiltration of fat in liver, and its preparation. The orally disintegrated silibinin tablet is prepared with silibinin as main material, and through adding stuffing, disintegrating agent, corrective, flow assistant and other supplementary material, pressing into tablet and other steps. The present invention has the features of low production cost, fast disintegration, good taste, etc.

Description

[technical field]

[0001] The present invention relates to a silibinin preparation which has the obvious effect of protecting and stabilizing liver cells and is used for treating acute and chronic hepatitis, liver cirrhosis, liver poisoning and other diseases, especially relates to a silybin preparation with quick release effect Orally disintegrating tablet formulation. [Background technique]

[0002] Silybin is a monomeric compound extracted from silymarin, which has the same indications and clinical efficacy as silymarin.

[0003] Silibinin has low bioavailability due to its poor solubility. At present, the dosage forms of silibinin preparations mainly include common tablet and capsule dosage forms. Orally disintegrating tablet preparations or related literature of silybin have not been found. The silibinin is made into an orally disintegrating tablet, which is convenient for patients to carry and take, and is conducive to improving the patient's compliance, thereby ensu...