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Flos chrysanthemi indici effective ingredient and application thereof

An effective part, the technology of wild chrysanthemum, applied in the field of biomedicine

Inactive Publication Date: 2012-10-24
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, we have found through research that the alcohol extract of wild chrysanthemum has a more significant effect of inhibiting hepatitis B virus, and by optimizing the extraction process, we have obtained an active part that has anti-hepatitis B virus and liver protection. At present, there has been no report at home and abroad

Method used

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  • Flos chrysanthemi indici effective ingredient and application thereof
  • Flos chrysanthemi indici effective ingredient and application thereof
  • Flos chrysanthemi indici effective ingredient and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The effective parts of the wild chrysanthemum of the present invention are extracted by following steps:

[0018] 1) Take wild chrysanthemum, add 5 times the weight of 90% ethanol to extract three times, combine the extracts, filter and concentrate the filtrate to extract;

[0019] 2) Take the extract and add water to make a suspension, add the extract to extract three times, the extract uses petroleum ether-ethyl acetate, the volume ratio is 40:1, after three extractions, combine and recover the solvent under reduced pressure to obtain the effective part .

Embodiment 2

[0021] The effective parts of the wild chrysanthemum of the present invention are extracted by following steps:

[0022] 1) Take wild chrysanthemum, add 8 times the weight of 75% ethanol to extract three times, combine the extracts, filter and concentrate the filtrate to extract;

[0023] 2) Take the extract and add water to make a suspension, add the extract to extract three times, the extract uses petroleum ether-ethyl acetate-ethanol, the volume ratio is 30:3:0.5, after three extractions, combine and recover the solvent under reduced pressure, That is, the effective part is obtained.

Embodiment 3

[0025] The effective parts of the wild chrysanthemum of the present invention are extracted by following steps:

[0026] 1) Take wild chrysanthemum, add 10 times the weight of 60% ethanol to extract three times, combine the extracts, filter and concentrate the filtrate to extract;

[0027] 2) Take the extract and add water to make a suspension, add the extract to extract five times, the extract uses petroleum ether-ethyl acetate-ethanol, the volume ratio is 10:5:1, and after five extractions, combine and recover under reduced pressure Solvent, that is, to obtain the effective site.

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Abstract

The invention discloses a flos chrysanthemi indici effective ingredient, which is extracted by a method comprising the following steps of: 1) taking flos chrysanthemi indici, adding 60-90% ethanol which is 5-10 times of the weight of the flos chrysanthemi indici to extract, filtering the extracting solution, and concentrating the filtrate into extract; and 2) adding water into the extract to prepare suspension, adding extract liquor to extract, and recovering the extract liquor to obtain the flos chrysanthemi indici effective ingredient. Experiments show that the flos chrysanthemi indici effective ingredient can more obviously inhibit hepatitis B virus, can also inhibit the glutamic-oxalacetic transaminease (AST) and glutamic-pyruvic transaminease (ALT) indexes of liver serum of the damaged liver, can reduce the tumor necrosis factor (TNF) content, liver indexes and malondialdehyde content of the liver serum of the damaged liver, and has good liver protection function. The flos chrysanthemi indici effective ingredient can be used as the active ingredient, and can be prepared into anti-hepatitis B virus medicaments or compositions with the liver protection function, such as food, drinks, health care products, drugs and the like, and the medicaments or compositions can be prepared into tablet, capsule, powder, injections and any other medically acceptable formulations.

Description

technical field [0001] The invention relates to an effective part of wild chrysanthemum flower for anti-hepatitis B virus and liver protection, as well as the application of the effective part, and belongs to the technical field of biomedicine. Background technique [0002] Hepatitis B is an infectious liver disease caused by the continuous replication of hepatitis B virus (HBV). my country is a big country with "hepatitis B", and there are more than 120 million hepatitis B carriers. The mortality rate of liver cirrhosis and liver cancer caused by hepatitis B ranks fifth in my country, and is called the "silent killer". Hepatitis still lacks effective means of control and a thorough solution, and there is no specific drug. Therefore, the research and development of effective drugs for treating hepatitis B has great social and practical significance. Traditional Chinese medicine has become the focus and hot spot of international attention because of its obvious overall effect...

Claims

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Application Information

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IPC IPC(8): A61K36/287A61P1/16A61P31/20A23L1/29A23L2/38A61K133/00A23L33/00
Inventor 毕跃峰王庆端江金花符玲王亚峰王振基李娟
Owner ZHENGZHOU UNIV
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