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Traditional Chinese medicine composition alleviating chemical liver injury and preparation method and Chinese materia medica preparation thereof

A technology for chemical liver injury and traditional Chinese medicine preparations, which can be used in drug combinations, pharmaceutical formulations, food preparation, etc., can solve problems such as aggravating liver oxidative damage, and achieve the effect of protecting liver

Active Publication Date: 2015-06-10
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Alcohol has no significant effect on the activity of superoxide dismutase (SOD) in the liver and mitochondria, but it can inhibit the activity of glutathione peroxidase (GPX1) in the liver and mitochondria, resulting in the depletion of reduced glutathione (GSH), oxidative damage to the liver

Method used

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  • Traditional Chinese medicine composition alleviating chemical liver injury and preparation method and Chinese materia medica preparation thereof
  • Traditional Chinese medicine composition alleviating chemical liver injury and preparation method and Chinese materia medica preparation thereof
  • Traditional Chinese medicine composition alleviating chemical liver injury and preparation method and Chinese materia medica preparation thereof

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preparation example Construction

[0032] The preparation method of described turmeric extract is more preferably:

[0033] Take turmeric and grind it, extract 2 times with 10 times the amount of 50% ethanol, each time for 2.5 hours, the extraction temperature is 60°C, combine the extracts, filter, concentrate until the mass ratio of turmeric and dry paste is 10:1, and obtain turmeric extract things.

[0034] According to pharmacological analysis: kudzu root clears heat and detoxifies, ganoderma lucidum enhances immunity, centella asiatica promotes blood circulation and removes blood stasis, rhodiola invigorates qi and invigorates the spleen, combined with turmeric to promote qi and break blood stasis, licorice harmonizes all medicines, together play a role in clearing damp heat, detoxifying Alcohol poisoning, soothes the liver and gallbladder, and has the effects of stagnation. Therefore, after the above-mentioned several substances are compounded and interact with each other, they have a good alleviating eff...

Embodiment 1

[0061] The preparation of embodiment 1 Chinese medicine composition

[0062] Mix 20 grams of kudzu root, 20 grams of ganoderma lucidum, 10 grams of centella asiatica, 10 grams of rhodiola rosea and 10 grams of licorice, add 700 grams of water, and extract once at 90 ° C for 0.6 hours; reduce pressure at 60 ° C Concentrate to a density of 1.0 g / ml, and spray dry to obtain the material; the inlet temperature of the hot air during the spray drying is 150°C, and the outlet temperature is 70°C.

[0063] The material is mixed with 1 gram of turmeric extract to obtain a traditional Chinese medicine composition for alleviating chemical liver damage.

Embodiment 2

[0064] The preparation of embodiment 2 Chinese medicine composition

[0065] Mix 60 grams of kudzu root, 60 grams of ganoderma lucidum, 50 grams of centella asiatica, 50 grams of rhodiola rosea and 30 grams of licorice, add 2500 grams of water, extract once at 95°C for 1.5 hours; reduce pressure at 60°C Concentrate to a density of 1.2g / ml, and spray dry to obtain the material; the hot air inlet temperature during the spray drying is 160°C, and the outlet temperature is 80°C.

[0066] The material is mixed with 10 grams of turmeric extract to obtain a traditional Chinese medicine composition for alleviating chemical liver damage.

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PUM

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Abstract

The invention provides a traditional Chinese medicine composition alleviating chemical liver injury. The composition is composed of, by weight, 2-6 parts of kudzu vine roots, 2-6 parts of lucid ganoderma, 1-5 parts of cat's-foot, 1-5 parts of rhodiola rosea, 1-3 parts of liquorice and 0.1-1 part of turmeric extractive, wherein the kudzu vine roots clear away heat and toxic materials, the lucid ganoderma enhances the immunity, the cat's-foot promotes blood circulation to remove blood stasis, the rhodiola rosea replenishes qi to invigorate the spleen, turmeric cooperates to promote the circulation of qi and disperse blood stasis, and the liquorice coordinates the drug actions of a prescription, so that the effects of clearing damp and heat, dispelling alcohol effects, unchoking the liver and gall and dissolving the indigestion are jointly achieved. Therefore, after the substances are compounded, interaction occurs, a good effect of alleviating the chemical liver injury is achieved, so that the effect of protecting the liver is achieved. A preparation method of the composition, Chinese materia medica preparation prepared with the compositions and auxiliary materials and application of the composition in preparing health care products which have protective functions for chemically damaged livers are further provided.

Description

technical field [0001] The invention relates to the field of health care products, in particular to a traditional Chinese medicine composition for alleviating chemical liver damage, a preparation method thereof and a traditional Chinese medicine preparation. Background technique [0002] Liver injury is a pathological change in the liver caused by factors such as viruses, drugs, poisons, alcohol, and hypoxia. The mechanism of liver injury is complex, which can be divided into chemical and immune. The chemical mechanism is mainly due to plasma membrane damage, free radical damage, mitochondrial dysfunction, metabolic disorder and other factors leading to liver function damage. Chemical liver injury can be caused by the effects of alcohol, chemical poisons in the environment, and certain drugs. [0003] At present, most of the clinical chemical liver injury is caused by alcohol, and the resulting alcoholic liver disease has also become the focus of social attention, includin...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P1/16A23L1/29A23L33/00
Inventor 萧伟李曼曼徐振秋孙文凯毕宇安邓辰辰王跃生陆艳芹许明君
Owner JIANGSU KANION PHARMA CO LTD
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