The invention discloses a pharmaceutical composition for curing oral excessive inflammation and gingival pain and swelling and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared from mesembryanthemum crystallinum, oriental wormwood, anemone rivularis, the root of red-rooted salvia, gynura bicolor, radix ampelopsis, matteuccia struthiopteris, Japanese betony, melinis repens, ajuga decumbus, giant reed shoot, styrax japonicus, root of subprostrate sophora, radix scrophulariae, spinach beet, aristolochia tuberose, girardinia suborbiculata, crinum leaf, honeysuckle, raw rhubarb, emblic leafflower leaf, liquorice, mint, borneol, Vitamin B, a sweetening agent, trisodium citrate and sorbitol. The pharmaceutical composition for curing oral excessive inflammation and gingival pain and swelling, provided by the invention is capable of clearing away heat and toxic materials, diminishing inflammation and disinfecting, and curing gingival pain and swelling, bleeding, and mouth and tongue sore. The preparation process is simple, the cost is lower, the effect is fast, the medicine property is mild, toxic and side effects do not exist and the use is convenient.