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Novel preparation for treating oral cavity inflammation and preparing method

A preparation and stomatitis technology, which is applied in the field of traditional Chinese medicine preparations and its preparation, can solve the problems of viral stomatitis, such as the lack of specific medicines, large dosage, and unqualified product quality.

Inactive Publication Date: 2006-10-25
LIVZON PHARM GRP INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a certain curative effect has been achieved, the clinical curative effect is gradually reduced due to the lack of specific drugs for viral stomatitis and the growing resistance of pathogenic bacteria to antibiotics.
The extensive use of antibiotics and corticosteroids will destroy the micro-ecological balance in the body, causing iatrogenic diseases and other serious side effects
Therefore, the effect of pure western medicine treatment is not ideal.
[0003] There are many kinds of Chinese medicines for treating stomatitis in the market now, but there are also following deficiencies: (1) quality aspect: the original prescription is easy to absorb moisture and agglomerate, causing proterties to be unqualified, and then causing product quality to be unqualified; 2) In terms of usability: Kouyan Granules use a large amount of excipients, the drug content is low, the curative effect is not obvious, and at the same time lead to a large dosage
[0010] But, when existing ripe Kouyan granule main raw material medicine adopts multi-energy extracting tank to extract, clear ointment yields ointment at 45-60% (relative density is at 1.17), and molding needs auxiliary material more, but tablet can not be compressed again Too big, otherwise it will be inconvenient to swallow and lose the meaning of dosage form reform

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Take gypsum 300g, Anemarrhena 100g, Rehmannia glutinosa 150g, Scrophulariaceae 800g, Artemisia annua 478.7g, Chuanketong 100g, Danzhu leaves 100g, Banlangen 150g, catechu 500g, Luzhu root 800g, licorice 30g, silicon dioxide 300g, micro Crystalline cellulose 200g, calcium sulfate 100g, catechin and water 100ml, heated to dissolve, filtered, the filtrate concentrated to a clear paste with a relative density of 1.19, and set aside. The rest of gypsum and other ten flavors are decocted twice with water for 2 hours each time, filtered, combined filtrates, and concentrated under reduced pressure to a clear paste with a relative density of 1.1. Take microcrystalline cellulose, silicon dioxide, and calcium sulfate prescription as auxiliary materials, add the above-mentioned clear paste, granulate, granulate, add magnesium stearate, talcum powder, mix well, press into 1000 tablets, coat with film, Subpackage, that is.

Embodiment 2

[0051] Take gypsum 1500g, Anemarrhena 500g, Rehmannia glutinosa 150g, Scrophulariaceae 150g, Artemisia annua 100g, Chuanketong 500g, Danzhu leaves 100g, Banlangen 150g, Catechu 100g, Luzhu root 150g, Licorice 200g, Silicon dioxide 80g, microcrystalline 20g of cellulose, 5g of calcium sulfate, and 100ml of water were added to catechin, heated to dissolve, filtered, and the filtrate was concentrated to a clear paste with a relative density of 1.19, and set aside. The rest of gypsum and other ten flavors are decocted twice with water for 2 hours each time, filtered, combined filtrates, and concentrated under reduced pressure to a clear paste with a relative density of 1.1. Take microcrystalline cellulose, silicon dioxide, and calcium sulfate prescription as auxiliary materials, add the above-mentioned clear paste, granulate, granulate, add magnesium stearate, talcum powder, mix well, press into 1000 tablets, coat with film, Subpackage, that is.

Embodiment 3

[0053] Take gypsum 843g, Anemarrhena 253g, Rehmannia glutinosa 422g, Scrophulariaceae 422g, Artemisia annua 253g, Chuanketong 253g, Bamboo leaf 253g, Radix isatidis 422g, Catechu 253g, Luzhu root 422g, Licorice 84g, Silicon dioxide 168.2, Microcrystalline 40g of cellulose, 20.5g of calcium sulfate, and 100ml of water were added to catechin, heated to dissolve, filtered, and the filtrate was concentrated to a clear paste with a relative density of 1.19, and set aside. The rest of gypsum and other ten flavors are decocted twice with water for 2 hours each time, filtered, combined filtrates, and concentrated under reduced pressure to a clear paste with a relative density of 1.1. Take microcrystalline cellulose, silicon dioxide, and calcium sulfate prescription as auxiliary materials, add the above-mentioned clear paste, granulate, granulate, add magnesium stearate, talcum powder, mix well, press into 1000 tablets, coat with film, Subpackage, that is.

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PUM

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Abstract

The present invention discloses a medicine preparation for effectively curing the diseases of stomatitis, mouth and tongue sores, flaring up of the stomach-fire and gingival cyst, etc. It is made up by using 11 Chinese medicinal materials of gypsum, anemarrhena root, rehmannia root, scrophularia root, bamboo leaf, licorice and others and adding auxiliary materials of silicon dioxide, microcrystalline cellulose and calcium sulfate through a certain preparation method.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular, the invention relates to a stomatitis preparation and a preparation method thereof. Background technique [0002] Stomatitis refers to acute oral mucositis and acute odontogenic infection, including herpetic gingival stomatitis, recurrent aphthous ulcer, erosive lichen planus, oral mucosal blood blisters, acute pharyngitis, glossitis, acute apical periodontitis And acute periodontitis, etc., excluding the above-mentioned diseases in patients with obvious symptoms such as diarrhea and dehydration, or those who are using adrenal corticosteroids, antibiotics, etc. The clinical manifestations of stomatitis are aphtha of the mouth and tongue, swollen and painful gums, which are relatively common oral diseases. Western medicine generally uses antibiotics, vitamins, and adrenal corticosteroids for systemic treatment. Although a certain curativ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/28A61K33/06A61P1/02
Inventor 张永嵩陈延清曾永清陶德胜曹晖
Owner LIVZON PHARM GRP INC
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